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Discovery and characterization of novel TRPML1 agonists.
Peng X, Holler CJ, Alves AF, Oliviera MG, Speake M, Pugliese A, Oskouei MR, de Freitas ID, Chen AY, Gallegos R, McTighe SM, Koenig G, Hurst RS, Blain JF, Lanter JC, Burnett DA. Peng X, et al. Among authors: lanter jc. Bioorg Med Chem Lett. 2024 Jan 15;98:129595. doi: 10.1016/j.bmcl.2023.129595. Epub 2023 Dec 22. Bioorg Med Chem Lett. 2024. PMID: 38141860
Discovery of oxazoline enhancers of cellular progranulin release.
Peng X, Lanter JC, Y-P Chen A, Brand MA, Wozniak MK, Hoekman S, Longin O, Regeling H, Zonneveld W, P L Bell R, Koenig G, Hurst RS, Blain JF, Burnett DA. Peng X, et al. Among authors: lanter jc. Bioorg Med Chem Lett. 2023 Jan 15;80:129048. doi: 10.1016/j.bmcl.2022.129048. Epub 2022 Nov 8. Bioorg Med Chem Lett. 2023. PMID: 36368496
Discovery of quinuclidine modulators of cellular progranulin.
Lanter JC, Chen AY, Williamson T, Koenig G, Blain JF, Burnett DA. Lanter JC, et al. Bioorg Med Chem Lett. 2021 Sep 1;47:128209. doi: 10.1016/j.bmcl.2021.128209. Epub 2021 Jun 18. Bioorg Med Chem Lett. 2021. PMID: 34153473
Conjugation of a peptide to an antibody engineered with free cysteines dramatically improves half-life and activity.
Camacho RC, You S, D'Aquino KE, Li W, Wang Y, Gunnet J, Littrell J, Qi JS, Kang L, Jian W, MacDonald M, Tat T, Steiner D, Zhang YM, Lanter J, Patch R, Zhang R, Li J, Edavettal S, Edwards W, Dinh T, Wang LY, Connor J, Hunter M, Chi E, Swanson RV, Leonard JN, Case MA. Camacho RC, et al. Among authors: lanter j. MAbs. 2020 Jan-Dec;12(1):1794687. doi: 10.1080/19420862.2020.1794687. MAbs. 2020. PMID: 32744157 Free PMC article.
Intestinal serine protease inhibition increases FGF21 and improves metabolism in obese mice.
Albarazanji K, Jennis M, Cavanaugh CR, Lang W, Singh B, Lanter JC, Lenhard JM, Hornby PJ. Albarazanji K, et al. Among authors: lanter jc. Am J Physiol Gastrointest Liver Physiol. 2019 May 1;316(5):G653-G667. doi: 10.1152/ajpgi.00404.2018. Epub 2019 Mar 28. Am J Physiol Gastrointest Liver Physiol. 2019. PMID: 30920846 Free PMC article.
Discovery of a GPR40 Superagonist: The Impact of Aryl Propionic Acid α-Fluorination.
Huang H, Meegalla SK, Lanter JC, Winters MP, Zhao S, Littrell J, Qi J, Rady B, Lee PS, Liu J, Martin T, Lam WW, Xu F, Lim HK, Wilde T, Silva J, Otieno M, Pocai A, Player MR. Huang H, et al. Among authors: lanter jc. ACS Med Chem Lett. 2018 Dec 3;10(1):16-21. doi: 10.1021/acsmedchemlett.8b00444. eCollection 2019 Jan 10. ACS Med Chem Lett. 2018. PMID: 30655940 Free PMC article.
36 results