Schinkel AH - Search Results

1

Liquid chromatography-tandem mass spectrometric assay for the quantitative determination of the tyrosine kinase inhibitor quizartinib in mouse plasma using salting-out liquid-liquid extraction.

Retmana IA, Wang J, Schinkel AH, Schellens JHM, Beijnen JH, Sparidans RW. Retmana IA, et al. Among authors: schinkel ah. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Sep 1;1061-1062:300-305. doi: 10.1016/j.jchromb.2017.07.034. Epub 2017 Jul 23. J Chromatogr B Analyt Technol Biomed Life Sci. 2017. PMID: 28772226 Free article.

2

Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs.

Schinkel AH, Smit JJ, van Tellingen O, Beijnen JH, Wagenaar E, van Deemter L, Mol CA, van der Valk MA, Robanus-Maandag EC, te Riele HP, et al. Schinkel AH, et al. Cell. 1994 May 20;77(4):491-502. doi: 10.1016/0092-8674(94)90212-7. Cell. 1994. PMID: 7910522

3

Altered pharmacokinetics of vinblastine in Mdr1a P-glycoprotein-deficient Mice.

van Asperen J, Schinkel AH, Beijnen JH, Nooijen WJ, Borst P, van Tellingen O. van Asperen J, et al. Among authors: schinkel ah. J Natl Cancer Inst. 1996 Jul 17;88(14):994-9. doi: 10.1093/jnci/88.14.994. J Natl Cancer Inst. 1996. PMID: 8667431

4

Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdr 1a P-glycoprotein.

Mayer U, Wagenaar E, Beijnen JH, Smit JW, Meijer DK, van Asperen J, Borst P, Schinkel AH. Mayer U, et al. Among authors: schinkel ah. Br J Pharmacol. 1996 Nov;119(5):1038-44. doi: 10.1111/j.1476-5381.1996.tb15775.x. Br J Pharmacol. 1996. PMID: 8922756 Free PMC article.

5

Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine.

Sparreboom A, van Asperen J, Mayer U, Schinkel AH, Smit JW, Meijer DK, Borst P, Nooijen WJ, Beijnen JH, van Tellingen O. Sparreboom A, et al. Among authors: schinkel ah. Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):2031-5. doi: 10.1073/pnas.94.5.2031. Proc Natl Acad Sci U S A. 1997. PMID: 9050899 Free PMC article.

6

Enhanced oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833.

van Asperen J, van Tellingen O, Sparreboom A, Schinkel AH, Borst P, Nooijen WJ, Beijnen JH. van Asperen J, et al. Among authors: schinkel ah. Br J Cancer. 1997;76(9):1181-3. doi: 10.1038/bjc.1997.530. Br J Cancer. 1997. PMID: 9365166 Free PMC article.

7

Full blockade of intestinal P-glycoprotein and extensive inhibition of blood-brain barrier P-glycoprotein by oral treatment of mice with PSC833.

Mayer U, Wagenaar E, Dorobek B, Beijnen JH, Borst P, Schinkel AH. Mayer U, et al. Among authors: schinkel ah. J Clin Invest. 1997 Nov 15;100(10):2430-6. doi: 10.1172/JCI119784. J Clin Invest. 1997. PMID: 9366556 Free PMC article.

8

Comparative pharmacokinetics of vinblastine after a 96-hour continuous infusion in wild-type mice and mice lacking mdr1a P-glycoprotein.

van Asperen J, van Tellingen O, Schinkel AH, Beijnen JH. van Asperen J, et al. Among authors: schinkel ah. J Pharmacol Exp Ther. 1999 Apr;289(1):329-33. J Pharmacol Exp Ther. 1999. PMID: 10087021

9

Increased accumulation of doxorubicin and doxorubicinol in cardiac tissue of mice lacking mdr1a P-glycoprotein.

van Asperen J, van Tellingen O, Tijssen F, Schinkel AH, Beijnen JH. van Asperen J, et al. Among authors: schinkel ah. Br J Cancer. 1999 Jan;79(1):108-13. doi: 10.1038/sj.bjc.6690019. Br J Cancer. 1999. PMID: 10408701 Free PMC article.

10

Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecan.

Jonker JW, Smit JW, Brinkhuis RF, Maliepaard M, Beijnen JH, Schellens JH, Schinkel AH. Jonker JW, et al. Among authors: schinkel ah. J Natl Cancer Inst. 2000 Oct 18;92(20):1651-6. doi: 10.1093/jnci/92.20.1651. J Natl Cancer Inst. 2000. PMID: 11036110

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