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Discovery of novel serine palmitoyltransferase inhibitors as cancer therapeutic agents.
Kojima T, Asano Y, Kurasawa O, Hirata Y, Iwamura N, Wong TT, Saito B, Tanaka Y, Arai R, Yonemori K, Miyamoto Y, Sagiya Y, Yaguchi M, Shibata S, Mizutani A, Sano O, Adachi R, Satomi Y, Hirayama M, Aoyama K, Hiura Y, Kiba A, Kitamura S, Imamura S. Kojima T, et al. Among authors: hiura y. Bioorg Med Chem. 2018 May 15;26(9):2452-2465. doi: 10.1016/j.bmc.2018.04.008. Epub 2018 Apr 4. Bioorg Med Chem. 2018. PMID: 29669694
Discovery of Potent, Selective, and Brain-Penetrant 1 H-Pyrazol-5-yl-1 H-pyrrolo[2,3- b]pyridines as Anaplastic Lymphoma Kinase (ALK) Inhibitors.
Fushimi M, Fujimori I, Wakabayashi T, Hasui T, Kawakita Y, Imamura K, Kato T, Murakami M, Ishii T, Kikko Y, Kasahara M, Nakatani A, Hiura Y, Miyamoto M, Saikatendu K, Zou H, Lane SW, Lawson JD, Imoto H. Fushimi M, et al. Among authors: hiura y. J Med Chem. 2019 May 23;62(10):4915-4935. doi: 10.1021/acs.jmedchem.8b01630. Epub 2019 May 3. J Med Chem. 2019. PMID: 31009559
UDP-glucuronosyltransferase 2B15 (UGT2B15) is the major enzyme responsible for sipoglitazar glucuronidation in humans: retrospective identification of the UGT isoform by in vitro analysis and the effect of UGT2B15*2 mutation.
Nishihara M, Hiura Y, Kawaguchi N, Takahashi J, Asahi S. Nishihara M, et al. Among authors: hiura y. Drug Metab Pharmacokinet. 2013;28(6):475-84. doi: 10.2133/dmpk.dmpk-13-rg-004. Epub 2013 May 7. Drug Metab Pharmacokinet. 2013. PMID: 23648677 Free article.
Discovery of a Novel Series of Pyrazolo[1,5-a]pyrimidine-Based Phosphodiesterase 2A Inhibitors Structurally Different from N-((1S)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915), for the Treatment of Cognitive Disorders.
Mikami S, Kawasaki M, Ikeda S, Negoro N, Nakamura S, Nomura I, Ashizawa T, Kokubo H, Hoffman ID, Zou H, Oki H, Uchiyama N, Hiura Y, Miyamoto M, Itou Y, Nakashima M, Iwashita H, Taniguchi T. Mikami S, et al. Among authors: hiura y. Chem Pharm Bull (Tokyo). 2017;65(11):1058-1077. doi: 10.1248/cpb.c17-00564. Chem Pharm Bull (Tokyo). 2017. PMID: 29093293 Free article.
84 results