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Amycomicin is a potent and specific antibiotic discovered with a targeted interaction screen.
Pishchany G, Mevers E, Ndousse-Fetter S, Horvath DJ Jr, Paludo CR, Silva-Junior EA, Koren S, Skaar EP, Clardy J, Kolter R. Pishchany G, et al. Among authors: horvath dj jr. Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):10124-10129. doi: 10.1073/pnas.1807613115. Epub 2018 Sep 18. Proc Natl Acad Sci U S A. 2018. PMID: 30228116 Free PMC article.
Antibacterial photosensitization through activation of coproporphyrinogen oxidase.
Surdel MC, Horvath DJ Jr, Lojek LJ, Fullen AR, Simpson J, Dutter BF, Salleng KJ, Ford JB, Jenkins JL, Nagarajan R, Teixeira PL, Albertolle M, Georgiev IS, Jansen ED, Sulikowski GA, Lacy DB, Dailey HA, Skaar EP. Surdel MC, et al. Among authors: horvath dj jr. Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):E6652-E6659. doi: 10.1073/pnas.1700469114. Epub 2017 Jul 24. Proc Natl Acad Sci U S A. 2017. PMID: 28739897 Free PMC article.
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