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Design and Synthesis of Tranylcypromine-Derived LSD1 Inhibitors with Improved hERG and Microsomal Stability Profiles.
Koda Y, Sato S, Yamamoto H, Niwa H, Watanabe H, Watanabe C, Sato T, Nakamura K, Tanaka A, Shirouzu M, Honma T, Fukami T, Koyama H, Umehara T. Koda Y, et al. Among authors: koyama h. ACS Med Chem Lett. 2022 Apr 29;13(5):848-854. doi: 10.1021/acsmedchemlett.2c00120. eCollection 2022 May 12. ACS Med Chem Lett. 2022. PMID: 35586426 Free PMC article.
Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors.
Shirai F, Tsumura T, Yashiroda Y, Yuki H, Niwa H, Sato S, Chikada T, Koda Y, Washizuka K, Yoshimoto N, Abe M, Onuki T, Mazaki Y, Hirama C, Fukami T, Watanabe H, Honma T, Umehara T, Shirouzu M, Okue M, Kano Y, Watanabe T, Kitamura K, Shitara E, Muramatsu Y, Yoshida H, Mizutani A, Seimiya H, Yoshida M, Koyama H. Shirai F, et al. Among authors: koyama h. J Med Chem. 2019 Apr 11;62(7):3407-3427. doi: 10.1021/acs.jmedchem.8b01888. Epub 2019 Apr 1. J Med Chem. 2019. PMID: 30883102
Design and Discovery of an Orally Efficacious Spiroindolinone-Based Tankyrase Inhibitor for the Treatment of Colon Cancer.
Shirai F, Mizutani A, Yashiroda Y, Tsumura T, Kano Y, Muramatsu Y, Chikada T, Yuki H, Niwa H, Sato S, Washizuka K, Koda Y, Mazaki Y, Jang MK, Yoshida H, Nagamori A, Okue M, Watanabe T, Kitamura K, Shitara E, Honma T, Umehara T, Shirouzu M, Fukami T, Seimiya H, Yoshida M, Koyama H. Shirai F, et al. Among authors: koyama h. J Med Chem. 2020 Apr 23;63(8):4183-4204. doi: 10.1021/acs.jmedchem.0c00045. Epub 2020 Apr 1. J Med Chem. 2020. PMID: 32202790
Identification of small molecule inhibitors of human COQ7.
Tsuganezawa K, Sekimata K, Nakagawa Y, Utata R, Nakamura K, Ogawa N, Koyama H, Shirouzu M, Fukami T, Kita K, Tanaka A. Tsuganezawa K, et al. Among authors: koyama h. Bioorg Med Chem. 2020 Jan 1;28(1):115182. doi: 10.1016/j.bmc.2019.115182. Epub 2019 Nov 9. Bioorg Med Chem. 2020. PMID: 31753803
The ubiquinone synthesis pathway is a promising drug target for Chagas disease.
Nara T, Nakagawa Y, Tsuganezawa K, Yuki H, Sekimata K, Koyama H, Ogawa N, Honma T, Shirouzu M, Fukami T, Matsuo Y, Inaoka DK, Kita K, Tanaka A. Nara T, et al. Among authors: koyama h. PLoS One. 2021 Feb 4;16(2):e0243855. doi: 10.1371/journal.pone.0243855. eCollection 2021. PLoS One. 2021. PMID: 33539347 Free PMC article.
1,802 results