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Open drug discovery in Alzheimer's disease.
Axtman AD, Brennan PE, Frappier-Brinton T, Betarbet R, Carter GW, Fu H, Gileadi O, Greenwood AK, Leal K, Longo FM, Mangravite LM, Edwards AM, Levey AI; Emory‐Sage‐SGC TREAT‐AD Center. Axtman AD, et al. Among authors: edwards am. Alzheimers Dement (N Y). 2023 May 17;9(2):e12394. doi: 10.1002/trc2.12394. eCollection 2023 Apr-Jun. Alzheimers Dement (N Y). 2023. PMID: 37215505 Free PMC article.
Scaling of an antibody validation procedure enables quantification of antibody performance in major research applications.
Ayoubi R, Ryan J, Biddle MS, Alshafie W, Fotouhi M, Bolivar SG, Ruiz Moleon V, Eckmann P, Worrall D, McDowell I, Southern K, Reintsch W, Durcan TM, Brown C, Bandrowski A, Virk H, Edwards AM, McPherson P, Laflamme C. Ayoubi R, et al. Among authors: edwards am. Elife. 2023 Nov 23;12:RP91645. doi: 10.7554/eLife.91645. Elife. 2023. PMID: 37995198 Free PMC article.
Reproducibility: Team up with industry.
Edwards A. Edwards A. Nature. 2016 Mar 17;531(7594):299-301. doi: 10.1038/531299a. Nature. 2016. PMID: 26983524 No abstract available.
Perspective: Science is still too closed.
Edwards A. Edwards A. Nature. 2016 May 12;533(7602):S70. doi: 10.1038/533S70a. Nature. 2016. PMID: 27167397 No abstract available.
A proposal for validation of antibodies.
Uhlen M, Bandrowski A, Carr S, Edwards A, Ellenberg J, Lundberg E, Rimm DL, Rodriguez H, Hiltke T, Snyder M, Yamamoto T. Uhlen M, et al. Nat Methods. 2016 Oct;13(10):823-7. doi: 10.1038/nmeth.3995. Epub 2016 Sep 5. Nat Methods. 2016. PMID: 27595404 Free PMC article.
A public-private partnership to unlock the untargeted kinome.
Knapp S, Arruda P, Blagg J, Burley S, Drewry DH, Edwards A, Fabbro D, Gillespie P, Gray NS, Kuster B, Lackey KE, Mazzafera P, Tomkinson NC, Willson TM, Workman P, Zuercher WJ. Knapp S, et al. Nat Chem Biol. 2013 Jan;9(1):3-6. doi: 10.1038/nchembio.1113. Nat Chem Biol. 2013. PMID: 23238671 No abstract available.
533 results