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Cooperative nutrient accumulation sustains growth of mammalian cells.
Son S, Stevens MM, Chao HX, Thoreen C, Hosios AM, Schweitzer LD, Weng Y, Wood K, Sabatini D, Vander Heiden MG, Manalis S. Son S, et al. Among authors: thoreen c. Sci Rep. 2015 Dec 1;5:17401. doi: 10.1038/srep17401. Sci Rep. 2015. PMID: 26620632 Free PMC article.
AMPK and p53 help cells through lean times.
Thoreen CC, Sabatini DM. Thoreen CC, et al. Cell Metab. 2005 May;1(5):287-8. doi: 10.1016/j.cmet.2005.04.009. Cell Metab. 2005. PMID: 16054073 Free article. Review.
Rapamycin inhibits mTORC1, but not completely.
Thoreen CC, Sabatini DM. Thoreen CC, et al. Autophagy. 2009 Jul;5(5):725-6. doi: 10.4161/auto.5.5.8504. Epub 2009 Jul 22. Autophagy. 2009. PMID: 19395872
mTOR Mediated Anti-Cancer Drug Discovery.
Liu Q, Thoreen C, Wang J, Sabatini D, Gray NS. Liu Q, et al. Among authors: thoreen c. Drug Discov Today Ther Strateg. 2009 Summer;6(2):47-55. doi: 10.1016/j.ddstr.2009.12.001. Drug Discov Today Ther Strateg. 2009. PMID: 20622997 Free PMC article.
Discovery of 9-(6-aminopyridin-3-yl)-1-(3-(trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective, and orally available mammalian target of rapamycin (mTOR) inhibitor for treatment of cancer.
Liu Q, Wang J, Kang SA, Thoreen CC, Hur W, Ahmed T, Sabatini DM, Gray NS. Liu Q, et al. Among authors: thoreen cc. J Med Chem. 2011 Mar 10;54(5):1473-80. doi: 10.1021/jm101520v. Epub 2011 Feb 15. J Med Chem. 2011. PMID: 21322566 Free PMC article.
41 results