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In vivo cytidine base editing of hepatocytes without detectable off-target mutations in RNA and DNA.
Villiger L, Rothgangl T, Witzigmann D, Oka R, Lin PJC, Qi W, Janjuha S, Berk C, Ringnalda F, Beattie MB, Stoffel M, Thöny B, Hall J, Rehrauer H, van Boxtel R, Tam YK, Schwank G. Villiger L, et al. Among authors: oka r. Nat Biomed Eng. 2021 Feb;5(2):179-189. doi: 10.1038/s41551-020-00671-z. Epub 2021 Jan 25. Nat Biomed Eng. 2021. PMID: 33495639 Free PMC article.
In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels.
Rothgangl T, Dennis MK, Lin PJC, Oka R, Witzigmann D, Villiger L, Qi W, Hruzova M, Kissling L, Lenggenhager D, Borrelli C, Egli S, Frey N, Bakker N, Walker JA 2nd, Kadina AP, Victorov DV, Pacesa M, Kreutzer S, Kontarakis Z, Moor A, Jinek M, Weissman D, Stoffel M, van Boxtel R, Holden K, Pardi N, Thöny B, Häberle J, Tam YK, Semple SC, Schwank G. Rothgangl T, et al. Among authors: oka r. Nat Biotechnol. 2021 Aug;39(8):949-957. doi: 10.1038/s41587-021-00933-4. Epub 2021 May 19. Nat Biotechnol. 2021. PMID: 34012094 Free PMC article.
Prime editing for functional repair in patient-derived disease models.
Schene IF, Joore IP, Oka R, Mokry M, van Vugt AHM, van Boxtel R, van der Doef HPJ, van der Laan LJW, Verstegen MMA, van Hasselt PM, Nieuwenhuis EES, Fuchs SA. Schene IF, et al. Among authors: oka r. Nat Commun. 2020 Oct 23;11(1):5352. doi: 10.1038/s41467-020-19136-7. Nat Commun. 2020. PMID: 33097693 Free PMC article.
Evaluating CRISPR-based prime editing for cancer modeling and CFTR repair in organoids.
Geurts MH, de Poel E, Pleguezuelos-Manzano C, Oka R, Carrillo L, Andersson-Rolf A, Boretto M, Brunsveld JE, van Boxtel R, Beekman JM, Clevers H. Geurts MH, et al. Among authors: oka r. Life Sci Alliance. 2021 Aug 9;4(10):e202000940. doi: 10.26508/lsa.202000940. Print 2021 Oct. Life Sci Alliance. 2021. PMID: 34373320 Free PMC article.
MutationalPatterns: the one stop shop for the analysis of mutational processes.
Manders F, Brandsma AM, de Kanter J, Verheul M, Oka R, van Roosmalen MJ, van der Roest B, van Hoeck A, Cuppen E, van Boxtel R. Manders F, et al. Among authors: oka r. BMC Genomics. 2022 Feb 15;23(1):134. doi: 10.1186/s12864-022-08357-3. BMC Genomics. 2022. PMID: 35168570 Free PMC article.
Elevated Mutational Age in Blood of Children Treated for Cancer Contributes to Therapy-Related Myeloid Neoplasms.
Bertrums EJM, Rosendahl Huber AKM, de Kanter JK, Brandsma AM, van Leeuwen AJCN, Verheul M, van den Heuvel-Eibrink MM, Oka R, van Roosmalen MJ, de Groot-Kruseman HA, Zwaan CM, Goemans BF, van Boxtel R. Bertrums EJM, et al. Among authors: oka r. Cancer Discov. 2022 Aug 5;12(8):1860-1872. doi: 10.1158/2159-8290.CD-22-0120. Cancer Discov. 2022. PMID: 35678530 Free PMC article.
Molecular characterization of Barrett's esophagus at single-cell resolution.
Busslinger GA, de Barbanson B, Oka R, Weusten BLA, de Maat M, van Hillegersberg R, Brosens LAA, van Boxtel R, van Oudenaarden A, Clevers H. Busslinger GA, et al. Among authors: oka r. Proc Natl Acad Sci U S A. 2021 Nov 23;118(47):e2113061118. doi: 10.1073/pnas.2113061118. Proc Natl Acad Sci U S A. 2021. PMID: 34795059 Free PMC article.
An organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity.
Calandrini C, Schutgens F, Oka R, Margaritis T, Candelli T, Mathijsen L, Ammerlaan C, van Ineveld RL, Derakhshan S, de Haan S, Dolman E, Lijnzaad P, Custers L, Begthel H, Kerstens HHD, Visser LL, Rookmaaker M, Verhaar M, Tytgat GAM, Kemmeren P, de Krijger RR, Al-Saadi R, Pritchard-Jones K, Kool M, Rios AC, van den Heuvel-Eibrink MM, Molenaar JJ, van Boxtel R, Holstege FCP, Clevers H, Drost J. Calandrini C, et al. Among authors: oka r. Nat Commun. 2020 Mar 11;11(1):1310. doi: 10.1038/s41467-020-15155-6. Nat Commun. 2020. PMID: 32161258 Free PMC article.
275 results