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Coordinated conformational changes in the V1 complex during V-ATPase reversible dissociation.
Nat Struct Mol Biol. 2022 May;29(5):430-439. doi: 10.1038/s41594-022-00757-z. Epub 2022 Apr 25.
Nat Struct Mol Biol. 2022.
PMID: 35469063
Cryo-EM of the Yeast VO Complex Reveals Distinct Binding Sites for Macrolide V-ATPase Inhibitors.
Keon KA, Benlekbir S, Kirsch SH, Müller R, Rubinstein JL.
Keon KA, et al.
ACS Chem Biol. 2022 Mar 18;17(3):619-628. doi: 10.1021/acschembio.1c00894. Epub 2022 Feb 11.
ACS Chem Biol. 2022.
PMID: 35148071
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CryoEM of endogenous mammalian V-ATPase interacting with the TLDc protein mEAK-7.
Tan YZ, Abbas YM, Wu JZ, Wu D, Keon KA, Hesketh GG, Bueler SA, Gingras AC, Robinson CV, Grinstein S, Rubinstein JL.
Tan YZ, et al. Among authors: keon ka.
Life Sci Alliance. 2022 Jul 6;5(11):e202201527. doi: 10.26508/lsa.202201527. Print 2022 Nov.
Life Sci Alliance. 2022.
PMID: 35794005
Free PMC article.
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Structure of V-ATPase from citrus fruit.
Tan YZ, Keon KA, Abdelaziz R, Imming P, Schulze W, Schumacher K, Rubinstein JL.
Tan YZ, et al. Among authors: keon ka.
Structure. 2022 Oct 6;30(10):1403-1410.e4. doi: 10.1016/j.str.2022.07.006. Epub 2022 Aug 29.
Structure. 2022.
PMID: 36041457
Free article.
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Toosendanin, a novel potent vacuolar-type H+-translocating ATPase inhibitor, sensitizes cancer cells to chemotherapy by blocking protective autophagy.
Dong Y, Zhu G, Wang SF, Keon KA, Rubinstein JL, Zeng SX, Zhang S, Chen QL, Fu J, Li M, Shen HM, Lu JJ, Chen XP, Lu JH.
Dong Y, et al. Among authors: keon ka.
Int J Biol Sci. 2022 Mar 28;18(7):2684-2702. doi: 10.7150/ijbs.71041. eCollection 2022.
Int J Biol Sci. 2022.
PMID: 35541921
Free PMC article.
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Inhibition of mitochondrial translation overcomes venetoclax resistance in AML through activation of the integrated stress response.
Sharon D, Cathelin S, Mirali S, Di Trani JM, Yanofsky DJ, Keon KA, Rubinstein JL, Schimmer AD, Ketela T, Chan SM.
Sharon D, et al. Among authors: keon ka.
Sci Transl Med. 2019 Oct 30;11(516):eaax2863. doi: 10.1126/scitranslmed.aax2863.
Sci Transl Med. 2019.
PMID: 31666400
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Decoding cardiogenic shock: assessing shock index and its variants as prognostic indicators for in-hospital mortality.
Colarusso L, Brahmbhatt DH, Scolari FL, Keon KA, Shin E, De Pellegrin Overgaard AI, Nisar M, Fung N, Ibrahimova N, Billia F, Overgaard CB, Luk AC.
Colarusso L, et al. Among authors: keon ka.
ESC Heart Fail. 2024 Jun 6. doi: 10.1002/ehf2.14853. Online ahead of print.
ESC Heart Fail. 2024.
PMID: 38845185
Free article.
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