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A novel potent class I HDAC inhibitor reverses the STAT4/p66Shc apoptotic defect in B cells from chronic lymphocytic leukemia patients.
Rossi S, Tatangelo V, Dichiara M, Butini S, Gemma S, Brogi S, Pasquini S, Cappello M, Vincenzi F, Varani K, Lopresti L, Malchiodi M, Carrara C, Gozzetti A, Bocchia M, Marotta G, Patrussi L, Carullo G, Baldari CT, Campiani G. Rossi S, et al. Among authors: carullo g. Biomed Pharmacother. 2024 May;174:116537. doi: 10.1016/j.biopha.2024.116537. Epub 2024 Apr 4. Biomed Pharmacother. 2024. PMID: 38579402 Free article.
Synthesis of Unsymmetrical Squaramides as Allosteric GSK-3β Inhibitors Promoting β-Catenin-Mediated Transcription of TCF/LEF in Retinal Pigment Epithelial Cells.
Carullo G, Bottoni L, Pasquini S, Papa A, Contri C, Brogi S, Calderone V, Orlandini M, Gemma S, Varani K, Butini S, Galvagni F, Vincenzi F, Campiani G. Carullo G, et al. ChemMedChem. 2022 Dec 16;17(24):e202200456. doi: 10.1002/cmdc.202200456. Epub 2022 Oct 27. ChemMedChem. 2022. PMID: 36194001
Azetidin-2-one-based small molecules as dual hHDAC6/HDAC8 inhibitors: Investigation of their mechanism of action and impact of dual inhibition profile on cell viability.
Federico S, Khan T, Fontana A, Brogi S, Benedetti R, Sarno F, Carullo G, Pezzotta A, Saraswati AP, Passaro E, Pozzetti L, Papa A, Relitti N, Gemma S, Butini S, Pistocchi A, Ramunno A, Vincenzi F, Varani K, Tatangelo V, Patrussi L, Baldari CT, Saponara S, Gorelli B, Lamponi S, Valoti M, Saccoccia F, Giannaccari M, Ruberti G, Herp D, Jung M, Altucci L, Campiani G. Federico S, et al. Among authors: carullo g. Eur J Med Chem. 2022 Aug 5;238:114409. doi: 10.1016/j.ejmech.2022.114409. Epub 2022 May 1. Eur J Med Chem. 2022. PMID: 35551034
Development of potent and selective FAAH inhibitors with improved drug-like properties as potential tools to treat neuroinflammatory conditions.
Papa A, Pasquini S, Galvani F, Cammarota M, Contri C, Carullo G, Gemma S, Ramunno A, Lamponi S, Gorelli B, Saponara S, Varani K, Mor M, Campiani G, Boscia F, Vincenzi F, Lodola A, Butini S. Papa A, et al. Among authors: carullo g. Eur J Med Chem. 2023 Jan 15;246:114952. doi: 10.1016/j.ejmech.2022.114952. Epub 2022 Nov 25. Eur J Med Chem. 2023. PMID: 36462439
Harnessing the Role of HDAC6 in Idiopathic Pulmonary Fibrosis: Design, Synthesis, Structural Analysis, and Biological Evaluation of Potent Inhibitors.
Campiani G, Cavella C, Osko JD, Brindisi M, Relitti N, Brogi S, Saraswati AP, Federico S, Chemi G, Maramai S, Carullo G, Jaeger B, Carleo A, Benedetti R, Sarno F, Lamponi S, Rottoli P, Bargagli E, Bertucci C, Tedesco D, Herp D, Senger J, Ruberti G, Saccoccia F, Saponara S, Gorelli B, Valoti M, Kennedy B, Sundaramurthi H, Butini S, Jung M, Roach KM, Altucci L, Bradding P, Christianson DW, Gemma S, Prasse A. Campiani G, et al. Among authors: carullo g. J Med Chem. 2021 Jul 22;64(14):9960-9988. doi: 10.1021/acs.jmedchem.1c00184. Epub 2021 Jul 12. J Med Chem. 2021. PMID: 34251197 Free PMC article.
86 results