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Modulation of TCR stimulation and pifithrin-α improves the genomic safety profile of CRISPR-engineered human T cells.
Ursch LT, Müschen JS, Ritter J, Klermund J, Bernard BE, Kolb S, Warmuth L, Andrieux G, Miller G, Jiménez-Muñoz M, Theis FJ, Boerries M, Busch DH, Cathomen T, Schumann K. Ursch LT, et al. Among authors: bernard be. Cell Rep Med. 2024 Dec 17;5(12):101846. doi: 10.1016/j.xcrm.2024.101846. Epub 2024 Dec 4. Cell Rep Med. 2024. PMID: 39637860
Targeted T cell receptor gene editing provides predictable T cell product function for immunotherapy.
Müller TR, Jarosch S, Hammel M, Leube J, Grassmann S, Bernard B, Effenberger M, Andrä I, Chaudhry MZ, Käuferle T, Malo A, Cicin-Sain L, Steinberger P, Feuchtinger T, Protzer U, Schumann K, Neuenhahn M, Schober K, Busch DH. Müller TR, et al. Cell Rep Med. 2021 Aug 17;2(8):100374. doi: 10.1016/j.xcrm.2021.100374. eCollection 2021 Aug 17. Cell Rep Med. 2021. PMID: 34467251 Free PMC article.