Feldman PL - Search Results

1

Phosphodiesterase type IV inhibition. Structure-activity relationships of 1,3-disubstituted pyrrolidines.

Feldman PL, Brackeen MF, Cowan DJ, Marron BE, Schoenen FJ, Stafford JA, Suh EM, Domanico PL, Rose D, Leesnitzer MA, et al. Feldman PL, et al. J Med Chem. 1995 Apr 28;38(9):1505-10. doi: 10.1021/jm00009a011. J Med Chem. 1995. PMID: 7739009

2

Design, synthesis, and pharmacological evaluation of ultrashort- to long-acting opioid analgetics.

Feldman PL, James MK, Brackeen MF, Bilotta JM, Schuster SV, Lahey AP, Lutz MW, Johnson MR, Leighton HJ. Feldman PL, et al. J Med Chem. 1991 Jul;34(7):2202-8. doi: 10.1021/jm00111a041. J Med Chem. 1991. PMID: 2066993

3

Design and synthesis of conformationally constrained analogues of 4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one (Ro 20-1724) as potent inhibitors of cAMP-specific phosphodiesterase.

Brackeen MF, Cowan DJ, Stafford JA, Schoenen FJ, Veal JM, Domanico PL, Rose D, Strickland AB, Verghese M, Feldman PL. Brackeen MF, et al. Among authors: feldman pl. J Med Chem. 1995 Nov 24;38(24):4848-54. doi: 10.1021/jm00024a012. J Med Chem. 1995. PMID: 7490734

4

Introduction of a conformational switching element on a pyrrolidine ring. Synthesis and evaluation of (R*,R*)-(+/-)-methyl 3-acetyl-4-[3- (cyclopentyloxy)-4-methoxyphenyl]-3-methyl-1-pyrrolidinecarboxylate, a potent and selective inhibitor of cAMP-specific phosphodiesterase.

Stafford JA, Veal JM, Feldman PL, Valvano NL, Baer PG, Brackeen MF, Brawley ES, Connolly KM, Domanico PL, Han B, et al. Stafford JA, et al. Among authors: feldman pl. J Med Chem. 1995 Dec 22;38(26):4972-5. doi: 10.1021/jm00026a003. J Med Chem. 1995. PMID: 8544172 No abstract available.

5

Dual inhibition of human type 4 phosphodiesterase isostates by (R, R)-(+/-)-methyl 3-acetyl-4-[3-(cyclopentyloxy)-4-methoxyphenyl]-3- methyl-1-pyrrolidinecarboxylate.

Tian G, Rocque WJ, Wiseman JS, Thompson IZ, Holmes WD, Domanico PL, Stafford JA, Feldman PL, Luther MA. Tian G, et al. Among authors: feldman pl. Biochemistry. 1998 May 12;37(19):6894-904. doi: 10.1021/bi972700v. Biochemistry. 1998. PMID: 9578576

6

Identification and structure-activity studies of novel ultrashort-acting benzodiazepine receptor agonists.

Stafford JA, Pacofsky GJ, Cox RF, Cowan JR, Dorsey GF Jr, Gonzales SS, Jung DK, Koszalka GW, McIntyre MS, Tidwell JH, Wiard RP, Feldman PL. Stafford JA, et al. Among authors: feldman pl. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3215-8. doi: 10.1016/s0960-894x(02)00512-7. Bioorg Med Chem Lett. 2002. PMID: 12372537

7

A pharmacodynamic model to investigate the structure-activity profile of a series of novel opioid analgesics.

Lutz MW, Morgan PH, James MK, Feldman PL, Brackeen MF, Lahey AP, James SV, Bilotta JM, Pressley JC. Lutz MW, et al. Among authors: feldman pl. J Pharmacol Exp Ther. 1994 Nov;271(2):795-803. J Pharmacol Exp Ther. 1994. PMID: 7965798

8

Relating the structure, activity, and physical properties of ultrashort-acting benzodiazepine receptor agonists.

Pacofsky GJ, Stafford JA, Cox RF, Cowan JR, Dorsey GF Jr, Gonzales SS, Kaldor I, Koszalka GW, Lovell GG, McIntyre MS, Tidwell JH, Todd D, Whitesell G, Wiard RP, Feldman PL. Pacofsky GJ, et al. Among authors: feldman pl. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3219-22. doi: 10.1016/s0960-894x(02)00513-9. Bioorg Med Chem Lett. 2002. PMID: 12372538

9

Discovery of a highly potent, nonabsorbable apical sodium-dependent bile acid transporter inhibitor (GSK2330672) for treatment of type 2 diabetes.

Wu Y, Aquino CJ, Cowan DJ, Anderson DL, Ambroso JL, Bishop MJ, Boros EE, Chen L, Cunningham A, Dobbins RL, Feldman PL, Harston LT, Kaldor IW, Klein R, Liang X, McIntyre MS, Merrill CL, Patterson KM, Prescott JS, Ray JS, Roller SG, Yao X, Young A, Yuen J, Collins JL. Wu Y, et al. Among authors: feldman pl. J Med Chem. 2013 Jun 27;56(12):5094-114. doi: 10.1021/jm400459m. Epub 2013 Jun 6. J Med Chem. 2013. PMID: 23678871

10

Opioid receptor activity of GI 87084B, a novel ultra-short acting analgesic, in isolated tissues.

James MK, Feldman PL, Schuster SV, Bilotta JM, Brackeen MF, Leighton HJ. James MK, et al. Among authors: feldman pl. J Pharmacol Exp Ther. 1991 Nov;259(2):712-8. J Pharmacol Exp Ther. 1991. PMID: 1658308

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

35 results

Search Page