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Preclinical and clinical pharmacodynamic assessment of L-778,123, a dual inhibitor of farnesyl:protein transferase and geranylgeranyl:protein transferase type-I.
Lobell RB, Liu D, Buser CA, Davide JP, DePuy E, Hamilton K, Koblan KS, Lee Y, Mosser S, Motzel SL, Abbruzzese JL, Fuchs CS, Rowinsky EK, Rubin EH, Sharma S, Deutsch PJ, Mazina KE, Morrison BW, Wildonger L, Yao SL, Kohl NE. Lobell RB, et al. Among authors: koblan ks. Mol Cancer Ther. 2002 Jul;1(9):747-58. Mol Cancer Ther. 2002. PMID: 12479371
Farnesyltransferase inhibitors and anti-Ras therapy.
Gibbs JB, Kohl NE, Koblan KS, Omer CA, Sepp-Lorenzino L, Rosen N, Anthony NJ, Conner MW, deSolms SJ, Williams TM, Graham SL, Hartman GD, Oliff A. Gibbs JB, et al. Among authors: koblan ks. Breast Cancer Res Treat. 1996;38(1):75-83. doi: 10.1007/BF01803786. Breast Cancer Res Treat. 1996. PMID: 8825125 Review.
Farnesyltransferase inhibitors: a new class of cancer chemotherapeutics.
Koblan KS, Kohl NE, Omer CA, Anthony NJ, Conner MW, deSolms SJ, Williams TM, Graham SL, Hartman GD, Oliff A, Gibbs JB. Koblan KS, et al. Biochem Soc Trans. 1996 Aug;24(3):688-92. doi: 10.1042/bst0240688. Biochem Soc Trans. 1996. PMID: 8878827 Review. No abstract available.
Farnesyl: proteintransferase inhibitors as agents to inhibit tumor growth.
Omer CA, Anthony NJ, Buser-Doepner CA, Burkhardt AL, deSolms SJ, Dinsmore CJ, Gibbs JB, Hartman GD, Koblan KS, Lobell RB, Oliff A, Williams TM, Kohl NE. Omer CA, et al. Among authors: koblan ks. Biofactors. 1997;6(3):359-66. doi: 10.1002/biof.5520060306. Biofactors. 1997. PMID: 9288406 Review.
Farnesyltransferase inhibitors versus Ras inhibitors.
Gibbs JB, Graham SL, Hartman GD, Koblan KS, Kohl NE, Omer CA, Oliff A. Gibbs JB, et al. Among authors: koblan ks. Curr Opin Chem Biol. 1997 Aug;1(2):197-203. doi: 10.1016/s1367-5931(97)80010-5. Curr Opin Chem Biol. 1997. PMID: 9667853 Review.
Non-thiol 3-aminomethylbenzamide inhibitors of farnesyl-protein transferase.
Ciccarone TM, MacTough SC, Williams TM, Dinsmore CJ, O'Neill TJ, Shah D, Culberson JC, Koblan KS, Kohl NE, Gibbs JB, Oliff AI, Graham SL, Hartman GD. Ciccarone TM, et al. Among authors: koblan ks. Bioorg Med Chem Lett. 1999 Jul 19;9(14):1991-6. doi: 10.1016/s0960-894x(99)00323-6. Bioorg Med Chem Lett. 1999. PMID: 10450968
129 results