Kohl NE - Search Results

1

Biochemical and biological analyses of farnesyl-protein transferase inhibitors.

Kohl NE, Koblan KS, Omer CA, Oliff A, Gibbs JB. Kohl NE, et al. Methods Mol Biol. 1998;84:283-91. doi: 10.1385/0-89603-488-7:283. Methods Mol Biol. 1998. PMID: 9666457

2

Preclinical and clinical pharmacodynamic assessment of L-778,123, a dual inhibitor of farnesyl:protein transferase and geranylgeranyl:protein transferase type-I.

Lobell RB, Liu D, Buser CA, Davide JP, DePuy E, Hamilton K, Koblan KS, Lee Y, Mosser S, Motzel SL, Abbruzzese JL, Fuchs CS, Rowinsky EK, Rubin EH, Sharma S, Deutsch PJ, Mazina KE, Morrison BW, Wildonger L, Yao SL, Kohl NE. Lobell RB, et al. Among authors: kohl ne. Mol Cancer Ther. 2002 Jul;1(9):747-58. Mol Cancer Ther. 2002. PMID: 12479371

3

A peptidomimetic inhibitor of farnesyl:protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines.

Sepp-Lorenzino L, Ma Z, Rands E, Kohl NE, Gibbs JB, Oliff A, Rosen N. Sepp-Lorenzino L, et al. Among authors: kohl ne. Cancer Res. 1995 Nov 15;55(22):5302-9. Cancer Res. 1995. PMID: 7585592

4

Pseudopeptide inhibitors of Ras farnesyl-protein transferase.

Graham SL, deSolms SJ, Giuliani EA, Kohl NE, Mosser SD, Oliff AI, Pompliano DL, Rands E, Breslin MJ, Deana AA, et al. Graham SL, et al. Among authors: kohl ne. J Med Chem. 1994 Mar 18;37(6):725-32. doi: 10.1021/jm00032a004. J Med Chem. 1994. PMID: 8145221

5

Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic.

Gibbs JB, Oliff A, Kohl NE. Gibbs JB, et al. Among authors: kohl ne. Cell. 1994 Apr 22;77(2):175-8. doi: 10.1016/0092-8674(94)90308-5. Cell. 1994. PMID: 8168127 Review. No abstract available.

6

Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton.

Prendergast GC, Davide JP, deSolms SJ, Giuliani EA, Graham SL, Gibbs JB, Oliff A, Kohl NE. Prendergast GC, et al. Among authors: kohl ne. Mol Cell Biol. 1994 Jun;14(6):4193-202. doi: 10.1128/mcb.14.6.4193-4202.1994. Mol Cell Biol. 1994. PMID: 8196657 Free PMC article.

7

Negative growth selection against rodent fibroblasts targeted for genetic inhibition of farnesyl transferase.

Prendergast GC, Davide JP, Kral A, Diehl R, Gibbs JB, Omer CA, Kohl NE. Prendergast GC, et al. Among authors: kohl ne. Cell Growth Differ. 1993 Sep;4(9):707-13. Cell Growth Differ. 1993. PMID: 8241019

8

Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo.

Gibbs JB, Pompliano DL, Mosser SD, Rands E, Lingham RB, Singh SB, Scolnick EM, Kohl NE, Oliff A. Gibbs JB, et al. Among authors: kohl ne. J Biol Chem. 1993 Apr 15;268(11):7617-20. J Biol Chem. 1993. PMID: 8463291 Free article.

9

Characterization of recombinant human farnesyl-protein transferase: cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases.

Omer CA, Kral AM, Diehl RE, Prendergast GC, Powers S, Allen CM, Gibbs JB, Kohl NE. Omer CA, et al. Among authors: kohl ne. Biochemistry. 1993 May 18;32(19):5167-76. doi: 10.1021/bi00070a028. Biochemistry. 1993. PMID: 8494894

10

Inhibition of Ras function in vitro and in vivo using inhibitors of farnesyl-protein transferase.

Kohl NE, Wilson FR, Thomas TJ, Bock RL, Mosser SD, Oliff A, Gibbs JB. Kohl NE, et al. Methods Enzymol. 1995;255:378-86. doi: 10.1016/s0076-6879(95)55040-2. Methods Enzymol. 1995. PMID: 8524123 No abstract available.

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