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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1948 1
1949 1
1950 2
1951 4
1952 5
1953 4
1954 1
1955 3
1956 7
1957 9
1958 9
1959 13
1960 18
1961 25
1962 54
1963 112
1964 235
1965 192
1966 190
1967 255
1968 296
1969 320
1970 355
1971 435
1972 424
1973 470
1974 477
1975 491
1976 524
1977 552
1978 572
1979 515
1980 566
1981 640
1982 658
1983 714
1984 792
1985 867
1986 837
1987 859
1988 844
1989 981
1990 947
1991 979
1992 994
1993 999
1994 964
1995 1006
1996 1051
1997 1019
1998 1008
1999 1005
2000 1028
2001 1009
2002 1115
2003 1192
2004 1206
2005 1321
2006 1406
2007 1414
2008 1415
2009 1582
2010 1597
2011 1765
2012 1853
2013 1897
2014 2083
2015 2090
2016 2084
2017 2079
2018 2098
2019 2216
2020 2427
2021 2499
2022 2311
2023 2240
2024 887

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62,106 results

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Page 1
The mechanism of action of methotrexate.
Cronstein BN. Cronstein BN. Rheum Dis Clin North Am. 1997 Nov;23(4):739-55. doi: 10.1016/s0889-857x(05)70358-6. Rheum Dis Clin North Am. 1997. PMID: 9361153 Free article. Review.
Because of methotrexate's well-documented efficacy in the treatment of rheumatoid arthritis, it is important that we understand the mechanism of action of this drug. There are two biochemical mechanisms by which methotrexate may modulate inflammation: (1) pro …
Because of methotrexate's well-documented efficacy in the treatment of rheumatoid arthritis, it is important that we understan …
Methotrexate: new therapeutic approaches.
Puig L. Puig L. Actas Dermosifiliogr. 2014 Jul-Aug;105(6):583-9. doi: 10.1016/j.ad.2012.11.017. Epub 2013 Feb 22. Actas Dermosifiliogr. 2014. PMID: 23434058 Free article. Review. English, Spanish.
Although the first study on the efficacy of methotrexate in the treatment of psoriasis was reported in 1958, scientific evidence for this indication has been scant until quite recently. ...Moreover, the incremental cost-effectiveness ratio for subcutaneous methotrexate …
Although the first study on the efficacy of methotrexate in the treatment of psoriasis was reported in 1958, scientific evidence for …
Side effects of methotrexate therapy for rheumatoid arthritis: A systematic review.
Wang W, Zhou H, Liu L. Wang W, et al. Eur J Med Chem. 2018 Oct 5;158:502-516. doi: 10.1016/j.ejmech.2018.09.027. Epub 2018 Sep 13. Eur J Med Chem. 2018. PMID: 30243154 Review.
Methotrexate (MTX) is used as an anchor disease-modifying anti-rheumatic drugs (DMARDs) in treating rheumatoid arthritis (RA) because of its potent efficacy and tolerability. ...
Methotrexate (MTX) is used as an anchor disease-modifying anti-rheumatic drugs (DMARDs) in treating rheumatoid arthritis (RA) because …
Methotrexate: Implications of pharmacogenetics in the treatment of patients with Rheumatoid Arthritis.
Torres RP, Santos FP, Branco JC. Torres RP, et al. ARP Rheumatol. 2022 Oct 1;1(3):225-229. ARP Rheumatol. 2022. PMID: 35724450 Free article. Review. English.
BACKGROUND: Methotrexate (MTX) is an anti-folate drug with anti-proliferative and anti-inflammatory effects. ...This review aims to describe the main genetic variants identified concerning proteins that play a role in methotrexate's kinetics and efficiency pr …
BACKGROUND: Methotrexate (MTX) is an anti-folate drug with anti-proliferative and anti-inflammatory effects. ...This review aims to d …
Methotrexate therapy.
Schep GN. Schep GN. Can J Gastroenterol. 1998 Jan-Feb;12(1):26-7. Can J Gastroenterol. 1998. PMID: 9544409 Review.
Methotrexate may be very helpful for your illness if proper care is taken in the use of this medication. ...Avoid pregnancy during and for several months after taking methotrexate. Keep methotrexate out of the reach of children. It has been prescribed for you …
Methotrexate may be very helpful for your illness if proper care is taken in the use of this medication. ...Avoid pregnancy during an …
Intrathecal methotrexate-induced neurotoxicities.
Nelson RW, Frank JT. Nelson RW, et al. Am J Hosp Pharm. 1981 Jan;38(1):65-8. Am J Hosp Pharm. 1981. PMID: 7011005 Review.
The pharmacokinetics, therapeutic index, neurotoxicities, methods of administration, and dosages of intrathecal methotrexate are reviewed. The intrathecal administration of methotrexate can provide therapeutic concentrations in the cerebrospinal fluid (CSF) without …
The pharmacokinetics, therapeutic index, neurotoxicities, methods of administration, and dosages of intrathecal methotrexate are revi …
Methotrexate in dermatology.
Bangert CA, Costner MI. Bangert CA, et al. Dermatol Ther. 2007 Jul-Aug;20(4):216-28. doi: 10.1111/j.1529-8019.2007.00135.x. Dermatol Ther. 2007. PMID: 17970887 Review.
In addition to its antiproliferative properties, methotrexate has other more recently recognized anti-inflammatory properties related to its effects on adenosine. Further research concerning its mechanism of action and genetic enzymatic variations suggest future possibilit …
In addition to its antiproliferative properties, methotrexate has other more recently recognized anti-inflammatory properties related …
Methotrexate.
Lester RS. Lester RS. Clin Dermatol. 1989 Jul-Sep;7(3):128-35. doi: 10.1016/0738-081x(89)90014-x. Clin Dermatol. 1989. PMID: 2680016 Review. No abstract available.
Methotrexate in rheumatoid arthritis. An update.
Bannwarth B, Labat L, Moride Y, Schaeverbeke T. Bannwarth B, et al. Drugs. 1994 Jan;47(1):25-50. doi: 10.2165/00003495-199447010-00003. Drugs. 1994. PMID: 7510620 Review.
Food intake has no significant effect on the pharmacokinetics of oral methotrexate. Methotrexate undergoes significant metabolism. The functionally important metabolites are the polyglutamated derivatives of methotrexate, which are selectively retained in the …
Food intake has no significant effect on the pharmacokinetics of oral methotrexate. Methotrexate undergoes significant metabol …
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