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Mendelian randomization study of diabetes and dementia in the Million Veteran Program.
Litkowski EM, Logue MW, Zhang R, Charest BR, Lange EM, Hokanson JE, Lynch JA, Vujkovic M, Phillips LS, Hauger RL, Lange LA, Raghavan S; VA Million Veteran Program (MVP). Litkowski EM, et al. Alzheimers Dement. 2023 Oct;19(10):4367-4376. doi: 10.1002/alz.13373. Epub 2023 Jul 7. Alzheimers Dement. 2023. PMID: 37417779
RESULTS: For each standard deviation increase in genetically predicted diabetes, we found increased odds of three dementia diagnoses in non-Hispanic White participants (all-cause: odds ratio [OR] = 1.07 [1.05-1.08], P = 3.40E-18; vascular: OR = 1.11 [1.07-1.15], P = 3.63E-09, Alz …
RESULTS: For each standard deviation increase in genetically predicted diabetes, we found increased odds of three dementia diagnoses in non- …
Endocrine network essential for reproductive success in Drosophila melanogaster.
Meiselman M, Lee SS, Tran RT, Dai H, Ding Y, Rivera-Perez C, Wijesekera TP, Dauwalder B, Noriega FG, Adams ME. Meiselman M, et al. Proc Natl Acad Sci U S A. 2017 May 9;114(19):E3849-E3858. doi: 10.1073/pnas.1620760114. Epub 2017 Apr 24. Proc Natl Acad Sci U S A. 2017. PMID: 28439025 Free PMC article.
Expression of ETH and ETH receptor genes is in turn dependent on ecdysone (20E). Furthermore, 20E receptor knockdown specifically in Inka cells reduces fecundity. Our findings indicate that the canonical developmental roles of 20E, ETH, and JH during juvenile …
Expression of ETH and ETH receptor genes is in turn dependent on ecdysone (20E). Furthermore, 20E receptor knockdown specifica …
Mendelian randomization study of diabetes and dementia in the Million Veteran Program.
Litkowski EM, Logue MW, Zhang R, Charest BR, Lange EM, Hokanson JE, Lynch JA, Vujkovic M, Phillips LS, Hauger RL, Lange LA, Raghavan S. Litkowski EM, et al. medRxiv [Preprint]. 2023 Mar 9:2023.03.07.23286526. doi: 10.1101/2023.03.07.23286526. medRxiv. 2023. PMID: 36945581 Free PMC article. Updated. Preprint.
RESULTS: For each standard deviation increase in genetically-predicted diabetes, we found increased odds of three dementia diagnoses in non-Hispanic White participants (all-cause: OR=1.07[1.05-1.08], P =3.40E-18; vascular: OR=1.11[1.07-1.15], P =3.63E-09, Alzheimer's: OR=1.06[1.0 …
RESULTS: For each standard deviation increase in genetically-predicted diabetes, we found increased odds of three dementia diagnoses in non- …
In vitro assessment and phase I randomized clinical trial of anfibatide a snake venom derived anti-thrombotic agent targeting human platelet GPIbα.
Li BX, Dai X, Xu XR, Adili R, Neves MAD, Lei X, Shen C, Zhu G, Wang Y, Zhou H, Hou Y, Ni T, Pasman Y, Yang Z, Qian F, Zhao Y, Gao Y, Liu J, Teng M, Marshall AH, Cerenzia EG, Li ML, Ni H. Li BX, et al. Sci Rep. 2021 Jun 3;11(1):11663. doi: 10.1038/s41598-021-91165-8. Sci Rep. 2021. PMID: 34083615 Free PMC article. Clinical Trial.
Secretory competence in a gateway endocrine cell conferred by the nuclear receptor βFTZ-F1 enables stage-specific ecdysone responses throughout development in Drosophila.
Cho KH, Daubnerová I, Park Y, Zitnan D, Adams ME. Cho KH, et al. Dev Biol. 2014 Jan 15;385(2):253-62. doi: 10.1016/j.ydbio.2013.11.003. Epub 2013 Nov 15. Dev Biol. 2014. PMID: 24247008 Free PMC article.
Successful execution of these developmental steps depends upon successive phases of rising and falling 20-hydroxyecdysone (20E) levels, leading to a cascade of nuclear receptor-driven transcriptional activity that enables stage- and tissue-specific responses to the steroid …
Successful execution of these developmental steps depends upon successive phases of rising and falling 20-hydroxyecdysone (20E) level …
Biochemical and molecular heterogeneity among isolates of Yersinia ruckeri from rainbow trout (Oncorhynchus mykiss, Walbaum) in North West Germany.
Huang Y, Runge M, Michael GB, Schwarz S, Jung A, Steinhagen D. Huang Y, et al. BMC Vet Res. 2013 Oct 21;9:215. doi: 10.1186/1746-6148-9-215. BMC Vet Res. 2013. PMID: 24144165 Free PMC article.
RESULTS: In total, 83 isolates were characterised, including 48 isolates collected during a field study in north west Germany. All isolates were confirmed as Y. ruckeri by the API 20E system. Five isolates were additionally confirmed as Y. ruckeri by Y. ruckeri-specific PC …
RESULTS: In total, 83 isolates were characterised, including 48 isolates collected during a field study in north west Germany. All isolates …