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1951 1
1984 1
1996 1
2000 2
2001 2
2004 1
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2009 1
2012 1
2013 2
2014 3
2015 2
2016 3
2017 1
2018 2
2019 3
2020 2
2021 8
2022 7
2023 5
2024 2

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Page 1
Pembrolizumab for Early Triple-Negative Breast Cancer.
Schmid P, Cortes J, Pusztai L, McArthur H, Kümmel S, Bergh J, Denkert C, Park YH, Hui R, Harbeck N, Takahashi M, Foukakis T, Fasching PA, Cardoso F, Untch M, Jia L, Karantza V, Zhao J, Aktan G, Dent R, O'Shaughnessy J; KEYNOTE-522 Investigators. Schmid P, et al. N Engl J Med. 2020 Feb 27;382(9):810-821. doi: 10.1056/NEJMoa1910549. N Engl J Med. 2020. PMID: 32101663 Clinical Trial.
Event-free Survival with Pembrolizumab in Early Triple-Negative Breast Cancer.
Schmid P, Cortes J, Dent R, Pusztai L, McArthur H, Kümmel S, Bergh J, Denkert C, Park YH, Hui R, Harbeck N, Takahashi M, Untch M, Fasching PA, Cardoso F, Andersen J, Patt D, Danso M, Ferreira M, Mouret-Reynier MA, Im SA, Ahn JH, Gion M, Baron-Hay S, Boileau JF, Ding Y, Tryfonidis K, Aktan G, Karantza V, O'Shaughnessy J; KEYNOTE-522 Investigators. Schmid P, et al. N Engl J Med. 2022 Feb 10;386(6):556-567. doi: 10.1056/NEJMoa2112651. N Engl J Med. 2022. PMID: 35139274 Clinical Trial.
Direct Comparison of the Tau PET Tracers (18)F-Flortaucipir and (18)F-MK-6240 in Human Subjects.
Gogola A, Minhas DS, Villemagne VL, Cohen AD, Mountz JM, Pascoal TA, Laymon CM, Mason NS, Ikonomovic MD, Mathis CA, Snitz BE, Lopez OL, Klunk WE, Lopresti BJ. Gogola A, et al. J Nucl Med. 2022 Jan;63(1):108-116. doi: 10.2967/jnumed.120.254961. Epub 2021 Apr 16. J Nucl Med. 2022. PMID: 33863821 Free PMC article.
SUV ratio (SUVR) outcomes were determined over 80-100 min ((18)F-flortaucipir) or 70-90 min ((18)F-MK-6240) normalized to cerebellar gray matter. ...The dynamic range of SUVRs in target regions was approximately 2-fold higher for (18)F-MK-6240 than for (18) …
SUV ratio (SUVR) outcomes were determined over 80-100 min ((18)F-flortaucipir) or 70-90 min ((18)F-MK-6240) normalized to cere …
First-in-Humans Evaluation of (18)F-SMBT-1, a Novel (18)F-Labeled Monoamine Oxidase-B PET Tracer for Imaging Reactive Astrogliosis.
Villemagne VL, Harada R, Doré V, Furumoto S, Mulligan R, Kudo Y, Burnham S, Krishnadas N, Bozinovski S, Huang K, Lopresti BJ, Yanai K, Rowe CC, Okamura N. Villemagne VL, et al. J Nucl Med. 2022 Oct;63(10):1551-1559. doi: 10.2967/jnumed.121.263254. Epub 2022 Jan 27. J Nucl Med. 2022. PMID: 35086898 Free PMC article.
Older participants underwent 3-dimensional magnetization-prepared rapid gradient-echo MRI and amyloid-beta, tau, and (18)F-SMBT-1 PET. To ascertain (18)F-SMBT-1 selectivity to MAO-B, 9 participants underwent 2 (18)F-SMBT-1 scans, before and after receiving 5 …
Older participants underwent 3-dimensional magnetization-prepared rapid gradient-echo MRI and amyloid-beta, tau, and (18)F-SMBT-1 PET …
Radiosynthesis, In Vitro and In Vivo Evaluation of [(18)F]CBD-2115 as a First-in-Class Radiotracer for Imaging 4R-Tauopathies.
Lindberg A, Knight AC, Sohn D, Rakos L, Tong J, Radelet A, Mason NS, Stehouwer JS, Lopresti BJ, Klunk WE, Sandell J, Sandberg A, Hammarström P, Svensson S, Mathis CA, Vasdev N. Lindberg A, et al. ACS Chem Neurosci. 2021 Feb 17;12(4):596-602. doi: 10.1021/acschemneuro.0c00801. Epub 2021 Jan 26. ACS Chem Neurosci. 2021. PMID: 33497190 Free PMC article.
In binding assays with human brain tissue homogenates, [(3)H]CBD-2115 has a higher affinity (4.9 nM) for progressive supranuclear palsy specific 4R-tau deposits than [(3)H]flortaucipir (45 nM) or [(3)H]MK-6240 (>50 nM). [(18)F]CBD-2115 was reliably synthesized (3-11% ra …
In binding assays with human brain tissue homogenates, [(3)H]CBD-2115 has a higher affinity (4.9 nM) for progressive supranuclear palsy spec …
The Association of Age-Related and Off-Target Retention with Longitudinal Quantification of [(18)F]MK6240 Tau PET in Target Regions.
Tissot C, Servaes S, Lussier FZ, Ferrari-Souza JP, Therriault J, Ferreira PCL, Bezgin G, Bellaver B, Leffa DT, Mathotaarachchi SS, Chamoun M, Stevenson J, Rahmouni N, Kang MS, Pallen V, Margherita-Poltronetti N, Wang YT, Fernandez-Arias J, Benedet AL, Zimmer ER, Soucy JP, Tudorascu DL, Cohen AD, Sharp M, Gauthier S, Massarweh G, Lopresti B, Klunk WE, Baker SL, Villemagne VL, Rosa-Neto P, Pascoal TA. Tissot C, et al. J Nucl Med. 2023 Mar;64(3):452-459. doi: 10.2967/jnumed.122.264434. Epub 2022 Nov 17. J Nucl Med. 2023. PMID: 36396455 Free PMC article.
6-(fluoro-(18)F)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([(18)F]MK6240) tau PET tracer quantifies the brain tau neurofibrillary tangle load in Alzheimer disease. ...Future postmortem studies should elucidate the source of the newly reported age-related …
6-(fluoro-(18)F)-3-(1H-pyrrolo[2,3-c]pyridin-1-yl)isoquinolin-5-amine ([(18)F]MK6240) tau PET tracer quantifies the brain tau …
Utility of 3'-[(18)F]fluoro-3'-deoxythymidine as a PET tracer to monitor response to gene therapy in a xenograft model of head and neck carcinoma.
Mason NS, Lopresti BJ, Ruszkiewicz J, Dong X, Joyce S, Leef G, Sen M, Wahed AS, Mathis CA, Grandis JR, Thomas SM. Mason NS, et al. Am J Nucl Med Mol Imaging. 2013;3(1):16-31. Epub 2013 Jan 5. Am J Nucl Med Mol Imaging. 2013. PMID: 23342298 Free PMC article.
Positron emission tomography (PET) offers functional non-invasive imaging of tumors. We determined the uptake of the PET tracers 2-deoxy-2-[(18)F]fluoro-D-glucose ([(18)F]FDG) and 3'-[(18)F]Fluoro-3'-deoxythymidine ([(18)F]FLT) in several SCCHN xenogra …
Positron emission tomography (PET) offers functional non-invasive imaging of tumors. We determined the uptake of the PET tracers 2-deoxy-2-[ …
Beyond monoamines: I. Novel targets and radiotracers for Positron emission tomography imaging in psychiatric disorders.
Lopresti BJ, Royse SK, Mathis CA, Tollefson SA, Narendran R. Lopresti BJ, et al. J Neurochem. 2023 Feb;164(3):364-400. doi: 10.1111/jnc.15615. Epub 2022 May 10. J Neurochem. 2023. PMID: 35536762 Free article. Review.
Early applications in psychiatry focused on identifying characteristic brain blood flow and metabolic derangements using radiotracers such as [(15) O]H(2) O and [(18) F]FDG. Despite the success of these techniques, it became apparent that more specific probes were needed t …
Early applications in psychiatry focused on identifying characteristic brain blood flow and metabolic derangements using radiotracers such a …
45 results