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2015 1
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2019 3
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2023 4
2024 1

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Page 1
Small molecule targeting of transcription-replication conflict for selective chemotherapy.
Gu L, Li M, Li CM, Haratipour P, Lingeman R, Jossart J, Gutova M, Flores L, Hyde C, Kenjić N, Li H, Chung V, Li H, Lomenick B, Von Hoff DD, Synold TW, Aboody KS, Liu Y, Horne D, Hickey RJ, Perry JJP, Malkas LH. Gu L, et al. Cell Chem Biol. 2023 Oct 19;30(10):1235-1247.e6. doi: 10.1016/j.chembiol.2023.07.001. Epub 2023 Aug 1. Cell Chem Biol. 2023. PMID: 37531956 Free PMC article.
Novel Peptide Therapeutic Approaches for Cancer Treatment.
Li CM, Haratipour P, Lingeman RG, Perry JJP, Gu L, Hickey RJ, Malkas LH. Li CM, et al. Cells. 2021 Oct 27;10(11):2908. doi: 10.3390/cells10112908. Cells. 2021. PMID: 34831131 Free PMC article. Review.
Full-length nuclear receptor allosteric regulation.
Choi WJ, Haratipour Z, Blind RD. Choi WJ, et al. J Lipid Res. 2023 Aug;64(8):100406. doi: 10.1016/j.jlr.2023.100406. Epub 2023 Jun 24. J Lipid Res. 2023. PMID: 37356665 Free PMC article. Review.
Uridine Bisphosphonates Differentiate Phosphoglycosyl Transferase Superfamilies.
Seebald LM, Haratipour P, Jacobs MR, Bernstein HM, Kashemirov BA, McKenna CE, Imperiali B. Seebald LM, et al. bioRxiv [Preprint]. 2023 Sep 19:2023.09.19.558431. doi: 10.1101/2023.09.19.558431. bioRxiv. 2023. PMID: 37786673 Free PMC article. Updated. Preprint.
With the goal of creating non-hydrolyzable mimics (UBP-sugars) of the UDP-sugar substrates as chemical probes to interrogate critical aspects of these essential enzymes, we designed and synthesized a series of uridine bisphosphonates (UBPs), wherein the diphosphate bridging oxyge …
With the goal of creating non-hydrolyzable mimics (UBP-sugars) of the UDP-sugar substrates as chemical probes to interrogate critical aspect …
Uridine Bisphosphonates Differentiate Phosphoglycosyl Transferase Superfamilies.
Seebald LM, Haratipour P, Jacobs MR, Bernstein HM, Kashemirov BA, McKenna CE, Imperiali B. Seebald LM, et al. J Am Chem Soc. 2024 Feb 7;146(5):3220-3229. doi: 10.1021/jacs.3c11402. Epub 2024 Jan 25. J Am Chem Soc. 2024. PMID: 38271668 Free PMC article.
We designed and synthesized a series of uridine bisphosphonates (UBPs), wherein the diphosphate of the UDP and UDP-sugar is replaced by a substituted methylene bisphosphonate (CXY-BPs; X/Y = F/F, Cl/Cl, (S)-H/F, (R)-H/F, H/H, CH(3)/CH(3)). UBPs and UBP …
We designed and synthesized a series of uridine bisphosphonates (UBPs), wherein the diphosphate of the UDP and UDP-sugar is replaced by a su …
A pre-catalytic non-covalent step governs DNA polymerase β fidelity.
Alnajjar KS, Krylov IS, Negahbani A, Haratipour P, Kashemirov BA, Huang J, Mahmoud M, McKenna CE, Goodman MF, Sweasy JB. Alnajjar KS, et al. Nucleic Acids Res. 2019 Dec 16;47(22):11839-11849. doi: 10.1093/nar/gkz1076. Nucleic Acids Res. 2019. PMID: 31732732 Free PMC article.
Kinetic Effects of β,γ-Modified Deoxynucleoside 5'-Triphosphate Analogues on RNA-Catalyzed Polymerization of DNA.
Setterholm NA, Haratipour P, Kashemirov BA, McKenna CE, Joyce GF. Setterholm NA, et al. Biochemistry. 2021 Jan 12;60(1):1-5. doi: 10.1021/acs.biochem.0c00779. Epub 2020 Dec 27. Biochemistry. 2021. PMID: 33356161 Free PMC article.
Insight can be gained into the transition state of the DNA polymerization reaction by studying the behavior of various beta,gamma-bridging substituted methylene (CXY; X, Y = H, halo, methyl) or imido (NH) dNTP analogues that differ with regard to the pK(a4) of the bisphosp …
Insight can be gained into the transition state of the DNA polymerization reaction by studying the behavior of various beta,gamma-bridging s …
16 results