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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1911 1
1913 1
1916 1
1917 1
1919 2
1920 3
1921 3
1922 2
1923 3
1924 3
1925 3
1926 4
1927 6
1928 2
1929 4
1930 6
1932 5
1933 1
1934 1
1935 3
1936 3
1937 1
1938 1
1939 3
1941 1
1942 2
1944 2
1945 2
1946 3
1947 1
1948 1
1949 2
1951 2
1952 4
1953 1
1954 3
1955 3
1956 5
1958 4
1959 4
1960 3
1961 3
1962 19
1963 20
1964 29
1965 25
1966 55
1967 46
1968 57
1969 65
1970 69
1971 103
1972 100
1973 137
1974 204
1975 2567
1976 2722
1977 2505
1978 2320
1979 2617
1980 3028
1981 3396
1982 3742
1983 4702
1984 5059
1985 5420
1986 5423
1987 5614
1988 5817
1989 6267
1990 6448
1991 6401
1992 6629
1993 6710
1994 6926
1995 6734
1996 7085
1997 6824
1998 6881
1999 6909
2000 7164
2001 7166
2002 7455
2003 7667
2004 8068
2005 8687
2006 9116
2007 9416
2008 9624
2009 9594
2010 10161
2011 10768
2012 11164
2013 11015
2014 10753
2015 10547
2016 8583
2017 7724
2018 10078
2019 10389
2020 11002
2021 11405
2022 10801
2023 9540
2024 6785
2025 1542

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340,212 results

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S-adenosylmethionine in liver health, injury, and cancer.
Lu SC, Mato JM. Lu SC, et al. Physiol Rev. 2012 Oct;92(4):1515-42. doi: 10.1152/physrev.00047.2011. Physiol Rev. 2012. PMID: 23073625 Free PMC article. Review.
S-adenosylmethionine (AdoMet, also known as SAM and SAMe) is the principal biological methyl donor synthesized in all mammalian cells but most abundantly in the liver. ...
S-adenosylmethionine (AdoMet, also known as SAM and SAMe) is the principal biological methyl donor synthesized in all mammalia …
Radical S-adenosylmethionine enzymes.
Broderick JB, Duffus BR, Duschene KS, Shepard EM. Broderick JB, et al. Chem Rev. 2014 Apr 23;114(8):4229-317. doi: 10.1021/cr4004709. Epub 2014 Jan 29. Chem Rev. 2014. PMID: 24476342 Free PMC article. Review. No abstract available.
SAMe and sexual functioning.
Dording CM, Mischoulon D, Shyu I, Alpert JE, Papakostas GI. Dording CM, et al. Eur Psychiatry. 2012 Aug;27(6):451-4. doi: 10.1016/j.eurpsy.2011.01.003. Epub 2011 Mar 12. Eur Psychiatry. 2012. PMID: 21398094 Clinical Trial.
S-adenosylmethionine radical enzymes.
Marsh EN, Patwardhan A, Huhta MS. Marsh EN, et al. Bioorg Chem. 2004 Oct;32(5):326-40. doi: 10.1016/j.bioorg.2004.06.001. Bioorg Chem. 2004. PMID: 15381399 Review.
The role of S-adenosylmethionine (SAM) as a precursor to organic radicals, generated by one-electron reduction of SAM and subsequent fission to form 5'-deoxyadenosyl radical and methionine, has been known for some time. ...
The role of S-adenosylmethionine (SAM) as a precursor to organic radicals, generated by one-electron reduction of SAM and subs …
Enzymatic Cascade Reactions in Biosynthesis.
Walsh CT, Moore BS. Walsh CT, et al. Angew Chem Int Ed Engl. 2019 May 20;58(21):6846-6879. doi: 10.1002/anie.201807844. Epub 2019 Feb 20. Angew Chem Int Ed Engl. 2019. PMID: 30156048 Free PMC article. Review.
Iron-based enzymes use O(2) to generate high valent iron-oxo species to homolyze unactivated C-H bonds in substrates to initiate skeletal rearrangements. At anaerobic end, enzymes reversibly cleave S-adenosylmethionine (SAM) to generate the 5'-deoxyadenosyl r …
Iron-based enzymes use O(2) to generate high valent iron-oxo species to homolyze unactivated C-H bonds in substrates to initiate skel …
S-Adenosylmethionine: more than just a methyl donor.
Lee YH, Ren D, Jeon B, Liu HW. Lee YH, et al. Nat Prod Rep. 2023 Sep 20;40(9):1521-1549. doi: 10.1039/d2np00086e. Nat Prod Rep. 2023. PMID: 36891755 Free PMC article. Review.
Safety and efficacy of S-adenosylmethionine (SAMe) for osteoarthritis.
Soeken KL, Lee WL, Bausell RB, Agelli M, Berman BM. Soeken KL, et al. J Fam Pract. 2002 May;51(5):425-30. J Fam Pract. 2002. PMID: 12019049 Review.
OBJECTIVE: We assessed the efficacy of S-adenosylmethionine (SAMe), a dietary supplement now available in the Unites States, compared with that of placebo or nonsteroidal anti-inflammatory drugs (NSAIDs) in the treatment of osteoarthritis (OA). ...
OBJECTIVE: We assessed the efficacy of S-adenosylmethionine (SAMe), a dietary supplement now available in the Unites States, c …
A Tug-of-War Over Methionine.
Xu K, Shyu A, Li MO. Xu K, et al. Cell Metab. 2020 Nov 3;32(5):699-701. doi: 10.1016/j.cmet.2020.10.016. Cell Metab. 2020. PMID: 33147482 Free article.
S-adenosylmethionine (SAMe) as treatment for depression: a systematic review.
Williams AL, Girard C, Jui D, Sabina A, Katz DL. Williams AL, et al. Clin Invest Med. 2005 Jun;28(3):132-9. Clin Invest Med. 2005. PMID: 16021987 Review.
PURPOSE: To assess the evidence evaluating S-adenosylmethionine (SAMe) supplementation as treatment for depression. METHODS: Searches of Medline, Psychinfo, AMED, and Cochrane Controlled Trials Register were conducted from database inception through September 2001. …
PURPOSE: To assess the evidence evaluating S-adenosylmethionine (SAMe) supplementation as treatment for depression. METHODS: S …
340,212 results
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