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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1919 2
1920 3
1921 3
1922 2
1923 3
1924 3
1925 3
1926 4
1927 6
1928 2
1929 4
1930 6
1932 5
1933 1
1934 1
1935 3
1936 3
1937 1
1938 1
1939 3
1941 1
1942 2
1944 2
1945 2
1946 3
1947 1
1948 1
1949 2
1951 2
1952 4
1953 1
1954 3
1955 3
1956 5
1958 4
1959 4
1960 3
1961 3
1962 19
1963 20
1964 29
1965 25
1966 55
1967 45
1968 57
1969 65
1970 69
1971 103
1972 100
1973 136
1974 202
1975 2567
1976 2722
1977 2505
1978 2318
1979 2617
1980 3027
1981 3396
1982 3740
1983 4701
1984 5059
1985 5418
1986 5422
1987 5597
1988 5779
1989 6224
1990 6403
1991 6365
1992 6588
1993 6663
1994 6881
1995 6702
1996 7035
1997 6761
1998 6807
1999 6802
2000 7021
2001 7019
2002 7315
2003 7521
2004 7895
2005 8526
2006 8915
2007 9248
2008 9430
2009 9398
2010 9971
2011 10561
2012 10965
2013 10768
2014 10346
2015 10031
2016 7992
2017 7105
2018 9520
2019 9808
2020 10371
2021 10670
2022 10065
2023 9127
2024 6550
2025 4838
2026 302

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335,298 results

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S-adenosylmethionine in liver health, injury, and cancer.
Lu SC, Mato JM. Lu SC, et al. Physiol Rev. 2012 Oct;92(4):1515-42. doi: 10.1152/physrev.00047.2011. Physiol Rev. 2012. PMID: 23073625 Free PMC article. Review.
S-adenosylmethionine (AdoMet, also known as SAM and SAMe) is the principal biological methyl donor synthesized in all mammalian cells but most abundantly in the liver. ...
S-adenosylmethionine (AdoMet, also known as SAM and SAMe) is the principal biological methyl donor synthesized in all mammalia …
Radical S-adenosylmethionine enzymes.
Broderick JB, Duffus BR, Duschene KS, Shepard EM. Broderick JB, et al. Chem Rev. 2014 Apr 23;114(8):4229-317. doi: 10.1021/cr4004709. Epub 2014 Jan 29. Chem Rev. 2014. PMID: 24476342 Free PMC article. Review. No abstract available.
SAMe and sexual functioning.
Dording CM, Mischoulon D, Shyu I, Alpert JE, Papakostas GI. Dording CM, et al. Eur Psychiatry. 2012 Aug;27(6):451-4. doi: 10.1016/j.eurpsy.2011.01.003. Epub 2011 Mar 12. Eur Psychiatry. 2012. PMID: 21398094 Clinical Trial.
Enzymatic Cascade Reactions in Biosynthesis.
Walsh CT, Moore BS. Walsh CT, et al. Angew Chem Int Ed Engl. 2019 May 20;58(21):6846-6879. doi: 10.1002/anie.201807844. Epub 2019 Feb 20. Angew Chem Int Ed Engl. 2019. PMID: 30156048 Free PMC article. Review.
Iron-based enzymes use O(2) to generate high valent iron-oxo species to homolyze unactivated C-H bonds in substrates to initiate skeletal rearrangements. At anaerobic end, enzymes reversibly cleave S-adenosylmethionine (SAM) to generate the 5'-deoxyadenosyl r …
Iron-based enzymes use O(2) to generate high valent iron-oxo species to homolyze unactivated C-H bonds in substrates to initiate skel …
GR15 peptide of S-adenosylmethionine synthase (SAMe) from Arthrospira platensis demonstrated antioxidant mechanism against H(2)O(2) induced oxidative stress in in-vitro MDCK cells and in-vivo zebrafish larvae model.
Velayutham M, Guru A, Arasu MV, Al-Dhabi NA, Choi KC, Elumalai P, Harikrishnan R, Arshad A, Arockiaraj J. Velayutham M, et al. J Biotechnol. 2021 Dec 10;342:79-91. doi: 10.1016/j.jbiotec.2021.10.010. Epub 2021 Oct 29. J Biotechnol. 2021. PMID: 34751134
The GR15, (1)GGGAFSGKDPTKVDR(15) was identified from the protein S-adenosylmethionine synthase (SAMe) expressed during the sulfur departed state of Arthrospira platensis (spirulina or cyanobacteria). ...Real-time PCR analysis found the up-regulation of ApSAMe expres …
The GR15, (1)GGGAFSGKDPTKVDR(15) was identified from the protein S-adenosylmethionine synthase (SAMe) expressed during the sul …
Methylation hypothesis.
Baldessarini RJ, Stramentinoli G, Lipinski JF. Baldessarini RJ, et al. Arch Gen Psychiatry. 1979 Mar;36(3):303-7. doi: 10.1001/archpsyc.1979.01780030069006. Arch Gen Psychiatry. 1979. PMID: 420548
L-Methionine had no behavioral effects in normal humans and failed to increase concentrations of S-adenosylmethionine (methyl donor) in human or rat blood, while increasing rat liver levels more than fivefold. Methionine or S-adenosylmethionine in very …
L-Methionine had no behavioral effects in normal humans and failed to increase concentrations of S-adenosylmethionine (methyl …
S-adenosylmethionine radical enzymes.
Marsh EN, Patwardhan A, Huhta MS. Marsh EN, et al. Bioorg Chem. 2004 Oct;32(5):326-40. doi: 10.1016/j.bioorg.2004.06.001. Bioorg Chem. 2004. PMID: 15381399 Review.
The role of S-adenosylmethionine (SAM) as a precursor to organic radicals, generated by one-electron reduction of SAM and subsequent fission to form 5'-deoxyadenosyl radical and methionine, has been known for some time. ...
The role of S-adenosylmethionine (SAM) as a precursor to organic radicals, generated by one-electron reduction of SAM and subs …
Safety and efficacy of S-adenosylmethionine (SAMe) for osteoarthritis.
Soeken KL, Lee WL, Bausell RB, Agelli M, Berman BM. Soeken KL, et al. J Fam Pract. 2002 May;51(5):425-30. J Fam Pract. 2002. PMID: 12019049 Review.
OBJECTIVE: We assessed the efficacy of S-adenosylmethionine (SAMe), a dietary supplement now available in the Unites States, compared with that of placebo or nonsteroidal anti-inflammatory drugs (NSAIDs) in the treatment of osteoarthritis (OA). ...
OBJECTIVE: We assessed the efficacy of S-adenosylmethionine (SAMe), a dietary supplement now available in the Unites States, c …
335,298 results
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