MFN2 overexpression in skeletal muscles of young and old mice causes a mild hypertrophy without altering mitochondrial respiration and H(2)O(2) emission.
Cefis M, Dargegen M, Marcangeli V, Taherkhani S, Dulac M, Leduc-Gaudet JP, Mayaki D, Hussain SNA, Gouspillou G.
Cefis M, et al.
Acta Physiol (Oxf). 2024 May;240(5):e14119. doi: 10.1111/apha.14119. Epub 2024 Feb 23.
Acta Physiol (Oxf). 2024.
PMID: 38400630
The impacts of MFN2 overexpression on muscle mass and fiber size (histology), mitochondrial respiration, and H(2)O(2) emission (Oroboros fluororespirometry), and various signaling pathways (qPCR and western blotting) were investigated. ...Importantly, MFN2 overexpression h …
The impacts of MFN2 overexpression on muscle mass and fiber size (histology), mitochondrial respiration, and H(2)O(2) emission (Orobo …