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Page 1
Molecular Pharmacology and Novel Potential Therapeutic Applications of Fingolimod.
Pournajaf S, Dargahi L, Javan M, Pourgholami MH. Pournajaf S, et al. Front Pharmacol. 2022 Feb 16;13:807639. doi: 10.3389/fphar.2022.807639. eCollection 2022. Front Pharmacol. 2022. PMID: 35250559 Free PMC article. Review.
In addition to exerting inhibitory effects on sphingolipid pathway enzymes, fingolimod also inhibits histone deacetylases, transient receptor potential cation channel subfamily M member 7 (TRMP7), cytosolic phospholipase A2alpha (cPLA2alpha), reduces lysophosphatidic acid …
In addition to exerting inhibitory effects on sphingolipid pathway enzymes, fingolimod also inhibits histone deacetylases, transient recepto …
In vitro and in vivo inhibition of liver cancer cells by 1,25-dihydroxyvitamin D3.
Pourgholami MH, Akhter J, Lu Y, Morris DL. Pourgholami MH, et al. Cancer Lett. 2000 Apr 3;151(1):97-102. doi: 10.1016/s0304-3835(99)00416-4. Cancer Lett. 2000. PMID: 10766428
Inhibitory effects of 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) on the proliferation of a variety of cancer cell lines have been extensively reported. We have studied the effect of 1,25-(OH)2D3 (10(-11)-10(-6) M) on the proliferation of a number of human and rat liver cancer …
Inhibitory effects of 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) on the proliferation of a variety of cancer cell lines have been extensively r …
In vitro and in vivo suppression of growth of hepatocellular carcinoma cells by albendazole.
Pourgholami MH, Woon L, Almajd R, Akhter J, Bowery P, Morris DL. Pourgholami MH, et al. Cancer Lett. 2001 Apr 10;165(1):43-9. doi: 10.1016/s0304-3835(01)00382-2. Cancer Lett. 2001. PMID: 11248417
Cell cycle analysis revealed that, depending on the dose employed, albendazole can arrest SKHEP-1 cells at both G0-G1 (250 nM) and G2-M (1000 nM) phases of the cycle. Albendazole treatment (300 mg/kg per day oral for 20 days) of nude mice inoculated subcutaneously with SKH …
Cell cycle analysis revealed that, depending on the dose employed, albendazole can arrest SKHEP-1 cells at both G0-G1 (250 nM) and G2-M …
Antitumor activity of albendazole against the human colorectal cancer cell line HT-29: in vitro and in a xenograft model of peritoneal carcinomatosis.
Pourgholami MH, Akhter J, Wang L, Lu Y, Morris DL. Pourgholami MH, et al. Cancer Chemother Pharmacol. 2005 May;55(5):425-32. doi: 10.1007/s00280-004-0927-6. Epub 2004 Nov 23. Cancer Chemother Pharmacol. 2005. PMID: 15565325
Studies on the mechanism of ABZ action, revealed arrest of HT-29 cells at the G(2)/M phase of the cell cycle, while TUNEL, DNA laddering and caspase-3 activity all confirmed ABZ induced apoptosis. ...The effect is thought to be brought about by arresting tumor cells at the …
Studies on the mechanism of ABZ action, revealed arrest of HT-29 cells at the G(2)/M phase of the cell cycle, while TUNEL, DNA ladder …
13 results