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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1947 1
1952 1
1958 1
1969 1
1970 4
1971 4
1972 2
1973 2
1974 5
1975 4
1976 7
1977 9
1978 4
1979 9
1980 9
1981 5
1982 10
1983 10
1984 8
1985 10
1986 7
1987 8
1988 10
1989 5
1990 10
1991 14
1992 11
1993 16
1994 11
1995 10
1996 10
1997 18
1998 21
1999 12
2000 13
2001 15
2002 18
2003 16
2004 15
2005 22
2006 15
2007 27
2008 22
2009 25
2010 18
2011 29
2012 22
2013 21
2014 35
2015 30
2016 40
2017 47
2018 39
2019 54
2020 52
2021 64
2022 51
2023 50
2024 34

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932 results

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Page 1
Visualization and analysis of gene expression in tissue sections by spatial transcriptomics.
Ståhl PL, Salmén F, Vickovic S, Lundmark A, Navarro JF, Magnusson J, Giacomello S, Asp M, Westholm JO, Huss M, Mollbrink A, Linnarsson S, Codeluppi S, Borg Å, Pontén F, Costea PI, Sahlén P, Mulder J, Bergmann O, Lundeberg J, Frisén J. Ståhl PL, et al. Science. 2016 Jul 1;353(6294):78-82. doi: 10.1126/science.aaf2403. Science. 2016. PMID: 27365449
By positioning histological sections on arrayed reverse transcription primers with unique positional barcodes, we demonstrate high-quality RNA-sequencing data with maintained two-dimensional positional information from the mouse brain and human breast cancer. Spatial trans …
By positioning histological sections on arrayed reverse transcription primers with unique positional barcodes, we demonstrate high-quality R …
Dual ontogeny of disease-associated microglia and disease inflammatory macrophages in aging and neurodegeneration.
Silvin A, Uderhardt S, Piot C, Da Mesquita S, Yang K, Geirsdottir L, Mulder K, Eyal D, Liu Z, Bridlance C, Thion MS, Zhang XM, Kong WT, Deloger M, Fontes V, Weiner A, Ee R, Dress R, Hang JW, Balachander A, Chakarov S, Malleret B, Dunsmore G, Cexus O, Chen J, Garel S, Dutertre CA, Amit I, Kipnis J, Ginhoux F. Silvin A, et al. Immunity. 2022 Aug 9;55(8):1448-1465.e6. doi: 10.1016/j.immuni.2022.07.004. Epub 2022 Aug 4. Immunity. 2022. PMID: 35931085 Free article.
Brain macrophage populations include parenchymal microglia, border-associated macrophages, and recruited monocyte-derived cells; together, they control brain development and homeostasis but are also implicated in aging pathogenesis and neurodegeneration. The phenoty …
Brain macrophage populations include parenchymal microglia, border-associated macrophages, and recruited monocyte-derived cells; toge …
An atlas of the protein-coding genes in the human, pig, and mouse brain.
Sjöstedt E, Zhong W, Fagerberg L, Karlsson M, Mitsios N, Adori C, Oksvold P, Edfors F, Limiszewska A, Hikmet F, Huang J, Du Y, Lin L, Dong Z, Yang L, Liu X, Jiang H, Xu X, Wang J, Yang H, Bolund L, Mardinoglu A, Zhang C, von Feilitzen K, Lindskog C, Pontén F, Luo Y, Hökfelt T, Uhlén M, Mulder J. Sjöstedt E, et al. Science. 2020 Mar 6;367(6482):eaay5947. doi: 10.1126/science.aay5947. Science. 2020. PMID: 32139519
To expand our basic understanding of the neurobiology of the brain and its diseases, we performed a comprehensive molecular dissection of 10 major brain regions and multiple subregions using a variety of transcriptomics methods and antibody-based mapping. ...The res …
To expand our basic understanding of the neurobiology of the brain and its diseases, we performed a comprehensive molecular dissectio …
A beginner's guide on the use of brain organoids for neuroscientists: a systematic review.
Mulder LA, Depla JA, Sridhar A, Wolthers K, Pajkrt D, Vieira de Sá R. Mulder LA, et al. Stem Cell Res Ther. 2023 Apr 15;14(1):87. doi: 10.1186/s13287-023-03302-x. Stem Cell Res Ther. 2023. PMID: 37061699 Free PMC article.
BACKGROUND: The first human brain organoid protocol was presented in the beginning of the previous decade, and since then, the field witnessed the development of many new brain region-specific models, and subsequent protocol adaptations and modifications. ...Here, w …
BACKGROUND: The first human brain organoid protocol was presented in the beginning of the previous decade, and since then, the field …
Distinct amyloid-β and tau-associated microglia profiles in Alzheimer's disease.
Gerrits E, Brouwer N, Kooistra SM, Woodbury ME, Vermeiren Y, Lambourne M, Mulder J, Kummer M, Möller T, Biber K, Dunnen WFAD, De Deyn PP, Eggen BJL, Boddeke EWGM. Gerrits E, et al. Acta Neuropathol. 2021 May;141(5):681-696. doi: 10.1007/s00401-021-02263-w. Epub 2021 Feb 20. Acta Neuropathol. 2021. PMID: 33609158 Free PMC article.
Here, we performed snRNAseq on 482,472 nuclei from non-demented control brains and AD brains containing only amyloid-beta plaques or both amyloid-beta plaques and tau pathology. ...
Here, we performed snRNAseq on 482,472 nuclei from non-demented control brains and AD brains containing only amyloid-beta plaq …
Stearoyl-CoA desaturase-1 impairs the reparative properties of macrophages and microglia in the brain.
Bogie JFJ, Grajchen E, Wouters E, Corrales AG, Dierckx T, Vanherle S, Mailleux J, Gervois P, Wolfs E, Dehairs J, Van Broeckhoven J, Bowman AP, Lambrichts I, Gustafsson JÅ, Remaley AT, Mulder M, Swinnen JV, Haidar M, Ellis SR, Ntambi JM, Zelcer N, Hendriks JJA. Bogie JFJ, et al. J Exp Med. 2020 May 4;217(5):e20191660. doi: 10.1084/jem.20191660. J Exp Med. 2020. PMID: 32097464 Free PMC article.
Single-cell spatial transcriptome reveals cell-type organization in the macaque cortex.
Chen A, Sun Y, Lei Y, Li C, Liao S, Meng J, Bai Y, Liu Z, Liang Z, Zhu Z, Yuan N, Yang H, Wu Z, Lin F, Wang K, Li M, Zhang S, Yang M, Fei T, Zhuang Z, Huang Y, Zhang Y, Xu Y, Cui L, Zhang R, Han L, Sun X, Chen B, Li W, Huangfu B, Ma K, Ma J, Li Z, Lin Y, Wang H, Zhong Y, Zhang H, Yu Q, Wang Y, Liu X, Peng J, Liu C, Chen W, Pan W, An Y, Xia S, Lu Y, Wang M, Song X, Liu S, Wang Z, Gong C, Huang X, Yuan Y, Zhao Y, Chai Q, Tan X, Liu J, Zheng M, Li S, Huang Y, Hong Y, Huang Z, Li M, Jin M, Li Y, Zhang H, Sun S, Gao L, Bai Y, Cheng M, Hu G, Liu S, Wang B, Xiang B, Li S, Li H, Chen M, Wang S, Li M, Liu W, Liu X, Zhao Q, Lisby M, Wang J, Fang J, Lin Y, Xie Q, Liu Z, He J, Xu H, Huang W, Mulder J, Yang H, Sun Y, Uhlen M, Poo M, Wang J, Yao J, Wei W, Li Y, Shen Z, Liu L, Liu Z, Xu X, Li C. Chen A, et al. Cell. 2023 Aug 17;186(17):3726-3743.e24. doi: 10.1016/j.cell.2023.06.009. Epub 2023 Jul 12. Cell. 2023. PMID: 37442136 Free article.
Elucidating the cellular organization of the cerebral cortex is critical for understanding brain structure and function. Using large-scale single-nucleus RNA sequencing and spatial transcriptomic analysis of 143 macaque cortical regions, we obtained a comprehensive atlas o …
Elucidating the cellular organization of the cerebral cortex is critical for understanding brain structure and function. Using large- …
A porcine brain-wide RNA editing landscape.
Huang J, Lin L, Dong Z, Yang L, Zheng T, Gu W, Zhang Y, Yin T, Sjöstedt E, Mulder J, Uhlén M, Kristiansen K, Bolund L, Luo Y. Huang J, et al. Commun Biol. 2021 Jun 10;4(1):717. doi: 10.1038/s42003-021-02238-3. Commun Biol. 2021. PMID: 34112917 Free PMC article.
Although hundreds of thousands of RNA editing sites have been reported in mammals, brain-wide analysis of the RNA editing in the mammalian brain remains rare. Here, a genome-wide RNA-editing investigation is performed in 119 samples, representing 30 anatomically def …
Although hundreds of thousands of RNA editing sites have been reported in mammals, brain-wide analysis of the RNA editing in the mamm …
Human Brain Organoids as Models for Central Nervous System Viral Infection.
Depla JA, Mulder LA, de Sá RV, Wartel M, Sridhar A, Evers MM, Wolthers KC, Pajkrt D. Depla JA, et al. Viruses. 2022 Mar 18;14(3):634. doi: 10.3390/v14030634. Viruses. 2022. PMID: 35337041 Free PMC article. Review.
Therefore, brain organoids have been increasingly used as brain models in research on various viruses, such as Zika virus, severe acute respiratory syndrome coronavirus 2, human cytomegalovirus, and herpes simplex virus. ...At the same time, we describe the limitati …
Therefore, brain organoids have been increasingly used as brain models in research on various viruses, such as Zika virus, sev …
Adaptation, perceptual learning, and plasticity of brain functions.
Horton JC, Fahle M, Mulder T, Trauzettel-Klosinski S. Horton JC, et al. Graefes Arch Clin Exp Ophthalmol. 2017 Mar;255(3):435-447. doi: 10.1007/s00417-016-3580-y. Epub 2017 Jan 14. Graefes Arch Clin Exp Ophthalmol. 2017. PMID: 28091782 Free PMC article. Review.
The capacity for functional restitution after brain damage is quite different in the sensory and motor systems. This series of presentations highlights the potential for adaptation, plasticity, and perceptual learning from an interdisciplinary perspective. ...This is based …
The capacity for functional restitution after brain damage is quite different in the sensory and motor systems. This series of presen …
932 results