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Page 1
A multinational report to characterise SARS-CoV-2 infection in people with cystic fibrosis.
Cosgriff R, Ahern S, Bell SC, Brownlee K, Burgel PR, Byrnes C, Corvol H, Cheng SY, Elbert A, Faro A, Goss CH, Gulmans V, Marshall BC, McKone E, Middleton PG, Ruseckaite R, Stephenson AL, Carr SB; Global Registry Harmonization Group. Cosgriff R, et al. Among authors: mckone e. J Cyst Fibros. 2020 May;19(3):355-358. doi: 10.1016/j.jcf.2020.04.012. Epub 2020 Apr 25. J Cyst Fibros. 2020. PMID: 32376098 Free PMC article.
Experience using centralized spirometry in the phase 2 randomized, placebo-controlled, double-blind trial of denufosol in patients with mild to moderate cystic fibrosis.
Goss CH, McKone EF, Mathews D, Kerr D, Wanger JS, Millard SP; Cystic Fibrosis Therapeutics Development Network. Goss CH, et al. Among authors: mckone ef. J Cyst Fibros. 2008 Mar;7(2):147-53. doi: 10.1016/j.jcf.2007.07.006. Epub 2007 Aug 28. J Cyst Fibros. 2008. PMID: 17728193 Free article. Clinical Trial.
A CFTR potentiator in patients with cystic fibrosis and the G551D mutation.
Ramsey BW, Davies J, McElvaney NG, Tullis E, Bell SC, Dřevínek P, Griese M, McKone EF, Wainwright CE, Konstan MW, Moss R, Ratjen F, Sermet-Gaudelus I, Rowe SM, Dong Q, Rodriguez S, Yen K, Ordoñez C, Elborn JS; VX08-770-102 Study Group. Ramsey BW, et al. Among authors: mckone ef. N Engl J Med. 2011 Nov 3;365(18):1663-72. doi: 10.1056/NEJMoa1105185. N Engl J Med. 2011. PMID: 22047557 Free PMC article. Clinical Trial.
Amikacin liposome inhalation suspension for chronic Pseudomonas aeruginosa infection in cystic fibrosis.
Bilton D, Pressler T, Fajac I, Clancy JP, Sands D, Minic P, Cipolli M, Galeva I, Solé A, Quittner AL, Liu K, McGinnis JP 2nd, Eagle G, Gupta R, Konstan MW; CLEAR-108 Study Group. Bilton D, et al. J Cyst Fibros. 2020 Mar;19(2):284-291. doi: 10.1016/j.jcf.2019.08.001. Epub 2019 Aug 23. J Cyst Fibros. 2020. PMID: 31451351 Free PMC article. Clinical Trial.
The global impact of SARS-CoV-2 in 181 people with cystic fibrosis.
McClenaghan E, Cosgriff R, Brownlee K, Ahern S, Burgel PR, Byrnes CA, Colombo C, Corvol H, Cheng SY, Daneau G, Elbert A, Faro A, Goss CH, Gulmans V, Gutierrez H, de Monestrol I, Jung A, Justus LN, Kashirskaya N, Marshall BC, McKone E, Middleton PG, Mondejar-Lopez P, Pastor-Vivero MD, Padoan R, Rizvi S, Ruseckaite R, Salvatore M, Stephenson AL, Filho LVRDS, Melo J, Zampoli M, Carr SB; Global Registry Harmonization Group. McClenaghan E, et al. Among authors: mckone e. J Cyst Fibros. 2020 Nov;19(6):868-871. doi: 10.1016/j.jcf.2020.10.003. Epub 2020 Nov 4. J Cyst Fibros. 2020. PMID: 33183965 Free PMC article.
Changes in fecal microbiota with CFTR modulator therapy: A pilot study.
Pope CE, Vo AT, Hayden HS, Weiss EJ, Durfey S, McNamara S, Ratjen A, Grogan B, Carter S, Nay L, Parsek MR, Singh PK, McKone EF, Aitken ML, Rosenfeld MR, Hoffman LR. Pope CE, et al. Among authors: mckone ef. J Cyst Fibros. 2021 Sep;20(5):742-746. doi: 10.1016/j.jcf.2020.12.002. Epub 2020 Dec 31. J Cyst Fibros. 2021. PMID: 33390317 Free PMC article.
COVID-19 vaccine prioritisation for people with cystic fibrosis.
Carr SB, Cosgriff R, Harutyunyan S, Middleton PG, Ruseckaite R, Ahern S, Daneau G, Filho LVRFDS, Stephenson AL, Cheng SY, Melo J, Corvol H, Burgel PR, Nährlich L, McKone E, Colombo C, Salvatore M, Padoan R, Abdrakhmanov O, Gulmans V, Byrnes CA, Amelina E, Kondratyeva E, Zhekayte E, Kashirskaya N, Zampoli M, Pastor-Vivero MD, Mondejar-Lopez P, de Monestrol I, Jung A, McClenaghan E, Brownlee K, Rizvi S, Goss CH, Elbert A, Faro A, Gutierrez H, Marshall BC. Carr SB, et al. Among authors: mckone e. J Cyst Fibros. 2021 Jul;20(4):715-716. doi: 10.1016/j.jcf.2021.03.028. Epub 2021 Apr 15. J Cyst Fibros. 2021. PMID: 33941502 Free PMC article. No abstract available.
Triple Therapy for Cystic Fibrosis Phe508del-Gating and -Residual Function Genotypes.
Barry PJ, Mall MA, Álvarez A, Colombo C, de Winter-de Groot KM, Fajac I, McBennett KA, McKone EF, Ramsey BW, Sutharsan S, Taylor-Cousar JL, Tullis E, Ahluwalia N, Jun LS, Moskowitz SM, Prieto-Centurion V, Tian S, Waltz D, Xuan F, Zhang Y, Rowe SM, Polineni D; VX18-445-104 Study Group. Barry PJ, et al. Among authors: mckone ef. N Engl J Med. 2021 Aug 26;385(9):815-825. doi: 10.1056/NEJMoa2100665. N Engl J Med. 2021. PMID: 34437784 Free PMC article. Clinical Trial.
Factors associated with clinical progression to severe COVID-19 in people with cystic fibrosis: A global observational study.
Carr SB, McClenaghan E, Elbert A, Faro A, Cosgriff R, Abdrakhmanov O, Brownlee K, Burgel PR, Byrnes CA, Cheng SY, Colombo C, Corvol H, Daneau G, Goss CH, Gulmans V, Gutierrez H, Harutyunyan S, Helmick M, Jung A, Kashirskaya N, McKone E, Melo J, Middleton PG, Mondejar-Lopez P, de Monestrol I, Nährlich L, Padoan R, Parker M, Pastor-Vivero MD, Rizvi S, Ruseckaite R, Salvatore M, da Silva-Filho LVRF, Versmessen N, Zampoli M, Marshall BC, Stephenson AL; CF Registry Global Collaboration. Carr SB, et al. Among authors: mckone e. J Cyst Fibros. 2022 Jul;21(4):e221-e231. doi: 10.1016/j.jcf.2022.06.006. Epub 2022 Jun 13. J Cyst Fibros. 2022. PMID: 35753987 Free PMC article.
Investigating serum extracellular vesicles in Cystic Fibrosis.
Trappe A, Lakkappa N, Carter S, Dillon E, Wynne K, McKone E, McNally P, Coppinger JA. Trappe A, et al. Among authors: mckone e. J Cyst Fibros. 2023 Jul;22(4):674-679. doi: 10.1016/j.jcf.2023.02.005. Epub 2023 Feb 27. J Cyst Fibros. 2023. PMID: 36858853 Free article.
Position paper: Models of post-transplant care for individuals with cystic fibrosis.
McKone E, Ramos KJ, Chaparro C, Blatter J, Hachem R, Anstead M, Vlahos F, Thaxton A, Hempstead S, Daniels T, Murray M, Sole A, Vos R, Tallarico E, Faro A, Pilewski JM. McKone E, et al. J Cyst Fibros. 2023 May;22(3):374-380. doi: 10.1016/j.jcf.2023.02.011. Epub 2023 Mar 5. J Cyst Fibros. 2023. PMID: 36882349 Free article.
Advancing the pipeline of cystic fibrosis clinical trials: a new roadmap with a global trial network perspective.
Mayer-Hamblett N, Clancy JP, Jain R, Donaldson SH, Fajac I, Goss CH, Polineni D, Ratjen F, Quon BS, Zemanick ET, Bell SC, Davies JC, Jain M, Konstan MW, Kerper NR, LaRosa T, Mall MA, McKone E, Pearson K, Pilewski JM, Quittell L, Rayment JH, Rowe SM, Taylor-Cousar JL, Retsch-Bogart G, Downey DG. Mayer-Hamblett N, et al. Among authors: mckone e. Lancet Respir Med. 2023 Oct;11(10):932-944. doi: 10.1016/S2213-2600(23)00297-7. Epub 2023 Sep 9. Lancet Respir Med. 2023. PMID: 37699421 Review.
Standards for the care of people with cystic fibrosis (CF); recognising and addressing CF health issues.
Burgel PR, Southern KW, Addy C, Battezzati A, Berry C, Bouchara JP, Brokaar E, Brown W, Azevedo P, Durieu I, Ekkelenkamp M, Finlayson F, Forton J, Gardecki J, Hodkova P, Hong G, Lowdon J, Madge S, Martin C, McKone E, Munck A, Ooi CY, Perrem L, Piper A, Prayle A, Ratjen F, Rosenfeld M, Sanders DB, Schwarz C, Taccetti G, Wainwright C, West NE, Wilschanski M, Bevan A, Castellani C, Drevinek P, Gartner S, Gramegna A, Lammertyn E, Landau EEC, Plant BJ, Smyth AR, van Koningsbruggen-Rietschel S, Middleton PG. Burgel PR, et al. Among authors: mckone e. J Cyst Fibros. 2024 Jan 16:S1569-1993(24)00005-5. doi: 10.1016/j.jcf.2024.01.005. Online ahead of print. J Cyst Fibros. 2024. PMID: 38233247 Free article.
Corrigendum to "WS04.1 The effect of Orkambi® on exercise capacity and muscle strength" [J Cyst Fibros, volume 16, supplement 1, June 2017, pages S6-S7].
Buckley R, Reilly CM, Kelly S, Ward E, O'Connor C, Carter S, Gallagher CG, McKone EF. Buckley R, et al. Among authors: mckone ef. J Cyst Fibros. 2017 Aug 18:S1569-1993(17)30771-3. doi: 10.1016/j.jcf.2017.06.003. Online ahead of print. J Cyst Fibros. 2017. PMID: 28826587 Free article. No abstract available.
Reduction in abdominal symptoms (CFAbd-Score), faecal M2-pyruvate-kinase and Calprotectin over one year of treatment with Elexacaftor-Tezacaftor-Ivacaftor in people with CF aged ≥12 years - The RECOVER study.
Mainz JG, Lester K, Elnazir B, Williamson M, McKone E, Cox D, Linnane B, Zagoya C, Duckstein F, Barucha A, Davies JC, McNally P; RECOVER Study Group. Mainz JG, et al. Among authors: mckone e. J Cyst Fibros. 2023 Oct 7:S1569-1993(23)00922-0. doi: 10.1016/j.jcf.2023.10.001. Online ahead of print. J Cyst Fibros. 2023. PMID: 37806792
Macrophage migration inhibitory factor enzymatic activity, lung inflammation, and cystic fibrosis.
Adamali H, Armstrong ME, McLaughlin AM, Cooke G, McKone E, Costello CM, Gallagher CG, Leng L, Baugh JA, Fingerle-Rowson G, Bucala RJ, McLoughlin P, Donnelly SC. Adamali H, et al. Among authors: mckone e. Am J Respir Crit Care Med. 2012 Jul 15;186(2):162-9. doi: 10.1164/rccm.201110-1864OC. Epub 2012 May 16. Am J Respir Crit Care Med. 2012. PMID: 22592805 Free PMC article.
Safety and efficacy of vanzacaftor-tezacaftor-deutivacaftor in adults with cystic fibrosis: randomised, double-blind, controlled, phase 2 trials.
Uluer AZ, MacGregor G, Azevedo P, Indihar V, Keating C, Mall MA, McKone EF, Ramsey BW, Rowe SM, Rubenstein RC, Taylor-Cousar JL, Tullis E, Yonker LM, Chu C, Lam AP, Nair N, Sosnay PR, Tian S, Van Goor F, Viswanathan L, Waltz D, Wang LT, Xi Y, Billings J, Horsley A; VX18-121-101; VX18-561-101 Study Groups. Uluer AZ, et al. Among authors: mckone ef. Lancet Respir Med. 2023 Jun;11(6):550-562. doi: 10.1016/S2213-2600(22)00504-5. Epub 2023 Feb 23. Lancet Respir Med. 2023. PMID: 36842446 Free article. Clinical Trial.
Repeatability of transient elastography in children.
Rowland M, McGee A, Broderick A, Drumm B, Connolly L, Daly LE, Drummond J, Fitzpatrick E, Linnane B, McCormick PA, McNally P, Rainford L, Bourke B; Cystic Fibrosis Registry of Ireland; Cystic Fibrosis Liver Disease Research Group. Rowland M, et al. Pediatr Res. 2020 Oct;88(4):587-592. doi: 10.1038/s41390-020-0916-4. Epub 2020 May 1. Pediatr Res. 2020. PMID: 32357363
Lemierre's syndrome.
O'Dwyer DN, Ryan S, O'Keefe T, Lyons J, Lavelle L, McKone E. O'Dwyer DN, et al. Among authors: mckone e. Ir J Med Sci. 2011 Jun;180(2):565-7. doi: 10.1007/s11845-008-0255-7. Epub 2008 Nov 11. Ir J Med Sci. 2011. PMID: 19002548
Differentiating combined pulmonary fibrosis and emphysema from pure emphysema: utility of late gadolinium-enhanced MRI.
Fleming H, Clifford SM, Haughey A, MacDermott R, McVeigh N, Healy GM, Lavelle L, Abbara S, Murphy DJ, Fabre A, McKone E, McCarthy C, Butler M, Doran P, Lynch DA, Keane MP, Dodd JD. Fleming H, et al. Among authors: mckone e. Eur Radiol Exp. 2020 Nov 3;4(1):61. doi: 10.1186/s41747-020-00187-w. Eur Radiol Exp. 2020. PMID: 33141269 Free PMC article.
EDNRA variants associate with smooth muscle mRNA levels, cell proliferation rates, and cystic fibrosis pulmonary disease severity.
Darrah R, McKone E, O'Connor C, Rodgers C, Genatossio A, McNamara S, Gibson R, Stuart Elborn J, Ennis M, Gallagher CG, Kalsheker N, Aitken M, Wiese D, Dunn J, Smith P, Pace R, Londono D, Goddard KA, Knowles MR, Drumm ML. Darrah R, et al. Among authors: mckone e. Physiol Genomics. 2010 Mar 3;41(1):71-7. doi: 10.1152/physiolgenomics.00185.2009. Epub 2009 Dec 22. Physiol Genomics. 2010. PMID: 20028935 Free PMC article.
Long-term safety and efficacy of elexacaftor/tezacaftor/ivacaftor in people with cystic fibrosis and at least one F508del allele: 144-week interim results from a 192-week open-label extension study.
Daines CL, Tullis E, Costa S, Linnemann RW, Mall MA, McKone EF, Polineni D, Quon BS, Ringshausen FC, Rowe SM, Selvadurai H, Taylor-Cousar JL, Withers NJ, Ahluwalia N, Moskowitz SM, Prieto-Centurion V, Tan YV, Tian S, Weinstock T, Xuan F, Zhang Y, Ramsey B, Griese M; VX17-445-105 Study Group. Daines CL, et al. Among authors: mckone ef. Eur Respir J. 2023 Dec 7;62(6):2202029. doi: 10.1183/13993003.02029-2022. Print 2023 Dec. Eur Respir J. 2023. PMID: 37945033 Free PMC article. Clinical Trial.
Elexacaftor/Tezacaftor/Ivacaftor Treatment and Depression-related Events.
Ramsey B, Correll CU, DeMaso DR, McKone E, Tullis E, Taylor-Cousar JL, Chu C, Volkova N, Ahluwalia N, Waltz D, Tian S, Mall MA. Ramsey B, et al. Among authors: mckone e. Am J Respir Crit Care Med. 2024 Feb 1;209(3):299-306. doi: 10.1164/rccm.202308-1525OC. Am J Respir Crit Care Med. 2024. PMID: 37890129 Free PMC article. Review.
Improvement in Lung Clearance Index and Chest Computed Tomography Scores with Elexacaftor/Tezacaftor/Ivacaftor Treatment in People with Cystic Fibrosis Aged 12 Years and Older - The RECOVER Trial.
McNally P, Lester K, Stone G, Elnazir B, Williamson M, Cox D, Linnane B, Kirwan L, Rea D, O'Regan P, Semple T, Saunders C, Tiddens HAWM, McKone E, Davies JC; RECOVER Study Group. McNally P, et al. Among authors: mckone e. Am J Respir Crit Care Med. 2023 Nov 1;208(9):917-929. doi: 10.1164/rccm.202308-1317OC. Am J Respir Crit Care Med. 2023. PMID: 37703083 Clinical Trial.
Phase 3 Open-Label Clinical Trial of Elexacaftor/Tezacaftor/Ivacaftor in Children Aged 2-5 Years with Cystic Fibrosis and at Least One F508del Allele.
Goralski JL, Hoppe JE, Mall MA, McColley SA, McKone E, Ramsey B, Rayment JH, Robinson P, Stehling F, Taylor-Cousar JL, Tullis E, Ahluwalia N, Chin A, Chu C, Lu M, Niu T, Weinstock T, Ratjen F, Rosenfeld M. Goralski JL, et al. Among authors: mckone e. Am J Respir Crit Care Med. 2023 Jul 1;208(1):59-67. doi: 10.1164/rccm.202301-0084OC. Am J Respir Crit Care Med. 2023. PMID: 36921081 Free PMC article.
Acute Pulmonary Exacerbation Phenotypes in Patients with Cystic Fibrosis.
Carter SC, Franciosi AN, O'Shea KM, O'Carroll OM, Sharma A, Bell A, Keogan B, O'Reilly P, Coughlan S, Law SM, Gray RD, Hisert KB, Singh PK, Cooke G, Grogan B, De Gascun CF, Gallagher CG, Nicholson TT, Quon BS, McKone EF. Carter SC, et al. Ann Am Thorac Soc. 2022 Nov;19(11):1818-1826. doi: 10.1513/AnnalsATS.202111-1266OC. Ann Am Thorac Soc. 2022. PMID: 35713619 Free PMC article.
Factors for severe outcomes following SARS-CoV-2 infection in people with cystic fibrosis in Europe.
Jung A, Orenti A, Dunlevy F, Aleksejeva E, Bakkeheim E, Bobrovnichy V, Carr SB, Colombo C, Corvol H, Cosgriff R, Daneau G, Dogru D, Drevinek P, Vukic AD, Fajac I, Fox A, Fustik S, Gulmans V, Harutyunyan S, Hatziagorou E, Kasmi I, Kayserová H, Kondratyeva E, Krivec U, Makukh H, Malakauskas K, McKone EF, Mei-Zahav M, de Monestrol I, Olesen HV, Padoan R, Parulava T, Pastor-Vivero MD, Pereira L, Petrova G, Pfleger A, Pop L, van Rens JG, Rodic M, Schlesser M, Storms V, Turcu O, Woz Niacki L, Yiallouros P, Zolin A, Downey DG, Naehrlich L. Jung A, et al. Among authors: mckone ef. ERJ Open Res. 2021 Dec 27;7(4):00411-2021. doi: 10.1183/23120541.00411-2021. eCollection 2021 Oct. ERJ Open Res. 2021. PMID: 34984210 Free PMC article.
Efficacy and safety of elexacaftor plus tezacaftor plus ivacaftor versus tezacaftor plus ivacaftor in people with cystic fibrosis homozygous for F508del-CFTR: a 24-week, multicentre, randomised, double-blind, active-controlled, phase 3b trial.
Sutharsan S, McKone EF, Downey DG, Duckers J, MacGregor G, Tullis E, Van Braeckel E, Wainwright CE, Watson D, Ahluwalia N, Bruinsma BG, Harris C, Lam AP, Lou Y, Moskowitz SM, Tian S, Yuan J, Waltz D, Mall MA; VX18-445-109 study group. Sutharsan S, et al. Among authors: mckone ef. Lancet Respir Med. 2022 Mar;10(3):267-277. doi: 10.1016/S2213-2600(21)00454-9. Epub 2021 Dec 20. Lancet Respir Med. 2022. PMID: 34942085 Clinical Trial.
Incidence of SARS-CoV-2 in people with cystic fibrosis in Europe between February and June 2020.
Naehrlich L, Orenti A, Dunlevy F, Kasmi I, Harutyunyan S, Pfleger A, Keegan S, Daneau G, Petrova G, Tješić-Drinković D, Yiallouros P, Bilkova A, Olesen HV, Burgel PR, Parulava T, Diamantea F, Párniczky A, McKone EF, Mei-Zahav M, Salvatore M, Colombo C, Aleksejeva E, Malakauskas K, Schlesser M, Fustik S, Turcu O, Zomer-van Ommen D, Wathne AS, Woźniacki Ł, Pereira L, Pop L, Kashirskaya N, Rodić M, Kayserova H, Krivecs U, Mondejar-Lopez P, de Monestrol I, Dogru D, Makukh H, Cosgriff R, van Koningsbruggen-Rietschel S, Jung A; European Cystic Fibrosis COVID project group. Naehrlich L, et al. Among authors: mckone ef. J Cyst Fibros. 2021 Jul;20(4):566-577. doi: 10.1016/j.jcf.2021.03.017. Epub 2021 Apr 18. J Cyst Fibros. 2021. PMID: 34016559 Free PMC article.
A Phase 3 Open-Label Study of Elexacaftor/Tezacaftor/Ivacaftor in Children 6 through 11 Years of Age with Cystic Fibrosis and at Least One F508del Allele.
Zemanick ET, Taylor-Cousar JL, Davies J, Gibson RL, Mall MA, McKone EF, McNally P, Ramsey BW, Rayment JH, Rowe SM, Tullis E, Ahluwalia N, Chu C, Ho T, Moskowitz SM, Noel S, Tian S, Waltz D, Weinstock TG, Xuan F, Wainwright CE, McColley SA. Zemanick ET, et al. Among authors: mckone ef. Am J Respir Crit Care Med. 2021 Jun 15;203(12):1522-1532. doi: 10.1164/rccm.202102-0509OC. Am J Respir Crit Care Med. 2021. PMID: 33734030 Free PMC article. Clinical Trial.
Survival estimates in European cystic fibrosis patients and the impact of socioeconomic factors: a retrospective registry cohort study.
McKone EF, Ariti C, Jackson A, Zolin A, Carr SB, Orenti A, van Rens JG, Lemonnier L, Macek M Jr, Keogh RH, Naehrlich L; European Cystic Fibrosis Society Patient Registry; ECFSPR contributors list consists of the representatives of the countries whose data is used in this article, and the members of the Scientific Committee who reviewed the initial data application and the final manuscript. Collaborating authors:. McKone EF, et al. Eur Respir J. 2021 Oct 1;58(3):2002288. doi: 10.1183/13993003.02288-2020. Print 2021 Sep. Eur Respir J. 2021. PMID: 33678607 Free article.
Long-term safety and efficacy of tezacaftor-ivacaftor in individuals with cystic fibrosis aged 12 years or older who are homozygous or heterozygous for Phe508del CFTR (EXTEND): an open-label extension study.
Flume PA, Biner RF, Downey DG, Brown C, Jain M, Fischer R, De Boeck K, Sawicki GS, Chang P, Paz-Diaz H, Rubin JL, Yang Y, Hu X, Pasta DJ, Millar SJ, Campbell D, Wang X, Ahluwalia N, Owen CA, Wainwright CE; VX14-661-110 study group. Flume PA, et al. Lancet Respir Med. 2021 Jul;9(7):733-746. doi: 10.1016/S2213-2600(20)30510-5. Epub 2021 Feb 10. Lancet Respir Med. 2021. PMID: 33581080
CF pulmonary exacerbations-Steps in the right direction.
Carter SC, McKone EF. Carter SC, et al. J Cyst Fibros. 2021 Jan;20(1):3-4. doi: 10.1016/j.jcf.2020.11.001. Epub 2020 Nov 10. J Cyst Fibros. 2021. PMID: 33187934 Free article. No abstract available.
Safety and Efficacy of Elexacaftor/Tezacaftor/Ivacaftor for 24 Weeks or Longer in People with Cystic Fibrosis and One or More F508del Alleles: Interim Results of an Open-Label Phase 3 Clinical Trial.
Griese M, Costa S, Linnemann RW, Mall MA, McKone EF, Polineni D, Quon BS, Ringshausen FC, Taylor-Cousar JL, Withers NJ, Moskowitz SM, Daines CL. Griese M, et al. Am J Respir Crit Care Med. 2021 Feb 1;203(3):381-385. doi: 10.1164/rccm.202008-3176LE. Am J Respir Crit Care Med. 2021. PMID: 32969708 Free PMC article. Clinical Trial. No abstract available.
Tocilizumab therapy in individuals with COVID-19 infection and hyperinflammatory state.
McCarthy C, Savinelli S, Feeney ER, Butler MW, O'Broin C, Ryan S, O'Neill L, Murphy DJ, Gallagher CG, McKone EF, Waqas S, Cotter A, Doran P, Keane MP, Mallon PW. McCarthy C, et al. Respirology. 2020 Oct;25(10):1090-1094. doi: 10.1111/resp.13912. Epub 2020 Jul 21. Respirology. 2020. PMID: 32696570 Free PMC article. No abstract available.
Increased extracellular vesicles mediate inflammatory signalling in cystic fibrosis.
Useckaite Z, Ward MP, Trappe A, Reilly R, Lennon J, Davage H, Matallanas D, Cassidy H, Dillon ET, Brennan K, Doyle SL, Carter S, Donnelly S, Linnane B, McKone EF, McNally P, Coppinger JA. Useckaite Z, et al. Thorax. 2020 Jun;75(6):449-458. doi: 10.1136/thoraxjnl-2019-214027. Epub 2020 Apr 7. Thorax. 2020. PMID: 32265339 Free PMC article.
Elexacaftor-Tezacaftor-Ivacaftor for Cystic Fibrosis with a Single Phe508del Allele.
Middleton PG, Mall MA, Dřevínek P, Lands LC, McKone EF, Polineni D, Ramsey BW, Taylor-Cousar JL, Tullis E, Vermeulen F, Marigowda G, McKee CM, Moskowitz SM, Nair N, Savage J, Simard C, Tian S, Waltz D, Xuan F, Rowe SM, Jain R; VX17-445-102 Study Group. Middleton PG, et al. Among authors: mckone ef. N Engl J Med. 2019 Nov 7;381(19):1809-1819. doi: 10.1056/NEJMoa1908639. Epub 2019 Oct 31. N Engl J Med. 2019. PMID: 31697873 Free PMC article. Clinical Trial.
Efficacy and safety of the elexacaftor plus tezacaftor plus ivacaftor combination regimen in people with cystic fibrosis homozygous for the F508del mutation: a double-blind, randomised, phase 3 trial.
Heijerman HGM, McKone EF, Downey DG, Van Braeckel E, Rowe SM, Tullis E, Mall MA, Welter JJ, Ramsey BW, McKee CM, Marigowda G, Moskowitz SM, Waltz D, Sosnay PR, Simard C, Ahluwalia N, Xuan F, Zhang Y, Taylor-Cousar JL, McCoy KS; VX17-445-103 Trial Group. Heijerman HGM, et al. Among authors: mckone ef. Lancet. 2019 Nov 23;394(10212):1940-1948. doi: 10.1016/S0140-6736(19)32597-8. Epub 2019 Oct 31. Lancet. 2019. PMID: 31679946 Free PMC article. Clinical Trial.
The future of cystic fibrosis care: a global perspective.
Bell SC, Mall MA, Gutierrez H, Macek M, Madge S, Davies JC, Burgel PR, Tullis E, Castaños C, Castellani C, Byrnes CA, Cathcart F, Chotirmall SH, Cosgriff R, Eichler I, Fajac I, Goss CH, Drevinek P, Farrell PM, Gravelle AM, Havermans T, Mayer-Hamblett N, Kashirskaya N, Kerem E, Mathew JL, McKone EF, Naehrlich L, Nasr SZ, Oates GR, O'Neill C, Pypops U, Raraigh KS, Rowe SM, Southern KW, Sivam S, Stephenson AL, Zampoli M, Ratjen F. Bell SC, et al. Among authors: mckone ef. Lancet Respir Med. 2020 Jan;8(1):65-124. doi: 10.1016/S2213-2600(19)30337-6. Epub 2019 Sep 27. Lancet Respir Med. 2020. PMID: 31570318 Free PMC article. Review.
Pathway analysis of a genome-wide gene by air pollution interaction study in asthmatic children.
Ierodiakonou D, Coull BA, Zanobetti A, Postma DS, Boezen HM, Vonk JM, McKone EF, Schildcrout JS, Koppelman GH, Croteau-Chonka DC, Lumley T, Koutrakis P, Schwartz J, Gold DR, Weiss ST. Ierodiakonou D, et al. J Expo Sci Environ Epidemiol. 2019 Jun;29(4):539-547. doi: 10.1038/s41370-019-0136-3. Epub 2019 Apr 26. J Expo Sci Environ Epidemiol. 2019. PMID: 31028280 Free PMC article.
Lung transplant referral for individuals with cystic fibrosis: Cystic Fibrosis Foundation consensus guidelines.
Ramos KJ, Smith PJ, McKone EF, Pilewski JM, Lucy A, Hempstead SE, Tallarico E, Faro A, Rosenbluth DB, Gray AL, Dunitz JM; CF Lung Transplant Referral Guidelines Committee. Ramos KJ, et al. Among authors: mckone ef. J Cyst Fibros. 2019 May;18(3):321-333. doi: 10.1016/j.jcf.2019.03.002. Epub 2019 Mar 27. J Cyst Fibros. 2019. PMID: 30926322 Free PMC article. Review.
Longitudinal Trends in Real-World Outcomes after Initiation of Ivacaftor. A Cohort Study from the Cystic Fibrosis Registry of Ireland.
Kirwan L, Fletcher G, Harrington M, Jeleniewska P, Zhou S, Casserly B, Gallagher CG, Greally P, Gunaratnam C, Herzig M, Linnane B, McElvaney NG, McKone EF, McNally P, Mullane D, Ní Chróinín M, O'Mahony M, Plant BJ, Jackson AD. Kirwan L, et al. Ann Am Thorac Soc. 2019 Feb;16(2):209-216. doi: 10.1513/AnnalsATS.201802-149OC. Ann Am Thorac Soc. 2019. PMID: 30427731
VX-659-Tezacaftor-Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles.
Davies JC, Moskowitz SM, Brown C, Horsley A, Mall MA, McKone EF, Plant BJ, Prais D, Ramsey BW, Taylor-Cousar JL, Tullis E, Uluer A, McKee CM, Robertson S, Shilling RA, Simard C, Van Goor F, Waltz D, Xuan F, Young T, Rowe SM; VX16-659-101 Study Group. Davies JC, et al. Among authors: mckone ef. N Engl J Med. 2018 Oct 25;379(17):1599-1611. doi: 10.1056/NEJMoa1807119. Epub 2018 Oct 18. N Engl J Med. 2018. PMID: 30334693 Free PMC article. Clinical Trial.
VX-445-Tezacaftor-Ivacaftor in Patients with Cystic Fibrosis and One or Two Phe508del Alleles.
Keating D, Marigowda G, Burr L, Daines C, Mall MA, McKone EF, Ramsey BW, Rowe SM, Sass LA, Tullis E, McKee CM, Moskowitz SM, Robertson S, Savage J, Simard C, Van Goor F, Waltz D, Xuan F, Young T, Taylor-Cousar JL; VX16-445-001 Study Group. Keating D, et al. Among authors: mckone ef. N Engl J Med. 2018 Oct 25;379(17):1612-1620. doi: 10.1056/NEJMoa1807120. Epub 2018 Oct 18. N Engl J Med. 2018. PMID: 30334692 Free PMC article. Clinical Trial.
Tezacaftor-Ivacaftor in Patients with Cystic Fibrosis Homozygous for Phe508del.
Taylor-Cousar JL, Munck A, McKone EF, van der Ent CK, Moeller A, Simard C, Wang LT, Ingenito EP, McKee C, Lu Y, Lekstrom-Himes J, Elborn JS. Taylor-Cousar JL, et al. N Engl J Med. 2017 Nov 23;377(21):2013-2023. doi: 10.1056/NEJMoa1709846. Epub 2017 Nov 3. N Engl J Med. 2017. PMID: 29099344 Free article. Clinical Trial.
Delayed neutrophil apoptosis enhances NET formation in cystic fibrosis.
Gray RD, Hardisty G, Regan KH, Smith M, Robb CT, Duffin R, Mackellar A, Felton JM, Paemka L, McCullagh BN, Lucas CD, Dorward DA, McKone EF, Cooke G, Donnelly SC, Singh PK, Stoltz DA, Haslett C, McCray PB, Whyte MKB, Rossi AG, Davidson DJ. Gray RD, et al. Thorax. 2018 Feb;73(2):134-144. doi: 10.1136/thoraxjnl-2017-210134. Epub 2017 Sep 15. Thorax. 2018. PMID: 28916704 Free PMC article.
Targeting the PI3K/Akt/mTOR signalling pathway in Cystic Fibrosis.
Reilly R, Mroz MS, Dempsey E, Wynne K, Keely SJ, McKone EF, Hiebel C, Behl C, Coppinger JA. Reilly R, et al. Among authors: mckone ef. Sci Rep. 2017 Aug 9;7(1):7642. doi: 10.1038/s41598-017-06588-z. Sci Rep. 2017. PMID: 28794469 Free PMC article.
Macrophage migration inhibitory factor enhances Pseudomonas aeruginosa biofilm formation, potentially contributing to cystic fibrosis pathogenesis.
Tynan A, Mawhinney L, Armstrong ME, O'Reilly C, Kennedy S, Caraher E, Jülicher K, O'Dwyer D, Maher L, Schaffer K, Fabre A, McKone EF, Leng L, Bucala R, Bernhagen J, Cooke G, Donnelly SC. Tynan A, et al. Among authors: mckone ef. FASEB J. 2017 Nov;31(11):5102-5110. doi: 10.1096/fj.201700463R. Epub 2017 Aug 2. FASEB J. 2017. PMID: 28768722 Free PMC article.
Our novel findings support the concept of an anti-MIF strategy that targets this enzymatic activity as a potential future antibacterial therapeutic approach.-Tynan, A., Mawhinney, L., Armstrong, M. E., O'Reilly, C., Kennedy, S., Caraher, E., Julicher, K., O'Dwyer, D …
Our novel findings support the concept of an anti-MIF strategy that targets this enzymatic activity as a potential future antibacterial ther …
Restoring Cystic Fibrosis Transmembrane Conductance Regulator Function Reduces Airway Bacteria and Inflammation in People with Cystic Fibrosis and Chronic Lung Infections.
Hisert KB, Heltshe SL, Pope C, Jorth P, Wu X, Edwards RM, Radey M, Accurso FJ, Wolter DJ, Cooke G, Adam RJ, Carter S, Grogan B, Launspach JL, Donnelly SC, Gallagher CG, Bruce JE, Stoltz DA, Welsh MJ, Hoffman LR, McKone EF, Singh PK. Hisert KB, et al. Among authors: mckone ef. Am J Respir Crit Care Med. 2017 Jun 15;195(12):1617-1628. doi: 10.1164/rccm.201609-1954OC. Am J Respir Crit Care Med. 2017. PMID: 28222269 Free PMC article.
Assessment of safety and efficacy of long-term treatment with combination lumacaftor and ivacaftor therapy in patients with cystic fibrosis homozygous for the F508del-CFTR mutation (PROGRESS): a phase 3, extension study.
Konstan MW, McKone EF, Moss RB, Marigowda G, Tian S, Waltz D, Huang X, Lubarsky B, Rubin J, Millar SJ, Pasta DJ, Mayer-Hamblett N, Goss CH, Morgan W, Sawicki GS. Konstan MW, et al. Lancet Respir Med. 2017 Feb;5(2):107-118. doi: 10.1016/S2213-2600(16)30427-1. Epub 2016 Dec 21. Lancet Respir Med. 2017. PMID: 28011037 Clinical Trial.
Do people have insight into their face recognition abilities?
Palermo R, Rossion B, Rhodes G, Laguesse R, Tez T, Hall B, Albonico A, Malaspina M, Daini R, Irons J, Al-Janabi S, Taylor LC, Rivolta D, McKone E. Palermo R, et al. Among authors: mckone e. Q J Exp Psychol (Hove). 2017 Feb;70(2):218-233. doi: 10.1080/17470218.2016.1161058. Epub 2016 Mar 23. Q J Exp Psychol (Hove). 2017. PMID: 26935244 Free article.
Pharmacogenetics of cystic fibrosis treatment.
Carter SC, McKone EF. Carter SC, et al. Pharmacogenomics. 2016 Aug;17(13):1453-63. doi: 10.2217/pgs.16.25. Epub 2016 Aug 4. Pharmacogenomics. 2016. PMID: 27490265 Review.
Personalised medicine in advanced cystic fibrosis.
McKone EF. McKone EF. Lancet Respir Med. 2016 Aug;4(8):594-595. doi: 10.1016/S2213-2600(16)30156-4. Epub 2016 Jun 10. Lancet Respir Med. 2016. PMID: 27298016 No abstract available.
Acute administration of ivacaftor to people with cystic fibrosis and a G551D-CFTR mutation reveals smooth muscle abnormalities.
Adam RJ, Hisert KB, Dodd JD, Grogan B, Launspach JL, Barnes JK, Gallagher CG, Sieren JP, Gross TJ, Fischer AJ, Cavanaugh JE, Hoffman EA, Singh PK, Welsh MJ, McKone EF, Stoltz DA. Adam RJ, et al. Among authors: mckone ef. JCI Insight. 2016 Apr 7;1(4):e86183. doi: 10.1172/jci.insight.86183. JCI Insight. 2016. PMID: 27158673 Free PMC article.
Ambient air pollution, lung function, and airway responsiveness in asthmatic children.
Ierodiakonou D, Zanobetti A, Coull BA, Melly S, Postma DS, Boezen HM, Vonk JM, Williams PV, Shapiro GG, McKone EF, Hallstrand TS, Koenig JQ, Schildcrout JS, Lumley T, Fuhlbrigge AN, Koutrakis P, Schwartz J, Weiss ST, Gold DR; Childhood Asthma Management Program Research Group. Ierodiakonou D, et al. J Allergy Clin Immunol. 2016 Feb;137(2):390-9. doi: 10.1016/j.jaci.2015.05.028. Epub 2015 Jul 14. J Allergy Clin Immunol. 2016. PMID: 26187234 Free PMC article.
Lumacaftor-Ivacaftor in Patients with Cystic Fibrosis Homozygous for Phe508del CFTR.
Wainwright CE, Elborn JS, Ramsey BW, Marigowda G, Huang X, Cipolli M, Colombo C, Davies JC, De Boeck K, Flume PA, Konstan MW, McColley SA, McCoy K, McKone EF, Munck A, Ratjen F, Rowe SM, Waltz D, Boyle MP; TRAFFIC Study Group; TRANSPORT Study Group. Wainwright CE, et al. Among authors: mckone ef. N Engl J Med. 2015 Jul 16;373(3):220-31. doi: 10.1056/NEJMoa1409547. Epub 2015 May 17. N Engl J Med. 2015. PMID: 25981758 Free PMC article. Clinical Trial.
Long-term safety and efficacy of ivacaftor in patients with cystic fibrosis who have the Gly551Asp-CFTR mutation: a phase 3, open-label extension study (PERSIST).
McKone EF, Borowitz D, Drevinek P, Griese M, Konstan MW, Wainwright C, Ratjen F, Sermet-Gaudelus I, Plant B, Munck A, Jiang Y, Gilmartin G, Davies JC; VX08-770-105 (PERSIST) Study Group. McKone EF, et al. Lancet Respir Med. 2014 Nov;2(11):902-910. doi: 10.1016/S2213-2600(14)70218-8. Epub 2014 Oct 9. Lancet Respir Med. 2014. PMID: 25311995 Clinical Trial.
Ivacaftor imaging response in cystic fibrosis.
Hoare S, McEvoy S, McCarthy CJ, Kilcoyne A, Brady D, Gibney B, Gallagher CG, McKone EF, Dodd JD. Hoare S, et al. Am J Respir Crit Care Med. 2014 Feb 15;189(4):484. doi: 10.1164/rccm.201308-1433IM. Am J Respir Crit Care Med. 2014. PMID: 24528318 No abstract available.
Aftereffects support opponent coding of face gender.
Pond S, Kloth N, McKone E, Jeffery L, Irons J, Rhodes G. Pond S, et al. Among authors: mckone e. J Vis. 2013 Dec 20;13(14):16. doi: 10.1167/13.14.16. J Vis. 2013. PMID: 24361588 Free article.
Pleural effusion arising from a rare pancreatic neoplasm.
Cushen B, McKeating A, Garvey JF, Dodd JD, Mulcahy H, Geoghegan J, McKone EF, Gallagher CG. Cushen B, et al. Eur Respir J. 2012 Nov;40(5):1298-300. doi: 10.1183/09031936.00035312. Eur Respir J. 2012. PMID: 23115315 Free article. No abstract available.
Asia has the global advantage: Race and visual attention.
McKone E, Aimola Davies A, Fernando D, Aalders R, Leung H, Wickramariyaratne T, Platow MJ. McKone E, et al. Vision Res. 2010 Jul 21;50(16):1540-9. doi: 10.1016/j.visres.2010.05.010. Epub 2010 May 17. Vision Res. 2010. PMID: 20488198 Free article.
A strong role for nature in face recognition.
McKone E, Palermo R. McKone E, et al. Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):4795-6. doi: 10.1073/pnas.1000567107. Epub 2010 Mar 8. Proc Natl Acad Sci U S A. 2010. PMID: 20212105 Free PMC article. No abstract available.
Configural processing and face viewpoint.
McKone E. McKone E. J Exp Psychol Hum Percept Perform. 2008 Apr;34(2):310-27. doi: 10.1037/0096-1523.34.2.310. J Exp Psychol Hum Percept Perform. 2008. PMID: 18377173
A long-term ecstasy-related change in visual perception.
Brown J, Edwards M, McKone E, Ward J. Brown J, et al. Among authors: mckone e. Psychopharmacology (Berl). 2007 Aug;193(3):437-46. doi: 10.1007/s00213-007-0785-0. Epub 2007 Apr 25. Psychopharmacology (Berl). 2007. PMID: 17457578 Clinical Trial.
The evidence rejects the expertise hypothesis: reply to Gauthier & Bukach.
McKone E, Robbins R. McKone E, et al. Cognition. 2007 May;103(2):331-6. doi: 10.1016/j.cognition.2006.05.014. Epub 2006 Jul 13. Cognition. 2007. PMID: 16842769
In Robbins, R. & McKone, E. (2006). No face-like processing for object-of-expertise in three behavioural tasks. ...
In Robbins, R. & McKone, E. (2006). No face-like processing for object-of-expertise in three behavioural tasks. ...
Environmental policy analysis: evaluating toxic impact assessment methods: what works best.
McKone EG. McKone EG. Environ Sci Technol. 1998 Mar 1;32(5):138A-44A. doi: 10.1021/es9840403. Environ Sci Technol. 1998. PMID: 21662154
HERTWICH Energy and Resources Group University of California Berkeley, CA 94720-3050 WILLIAM S. PEASE Environmental Defense Fund Oakland, CA 95616 THOMAS E. MCKONE Environmental Health Science University of California Berkeley, CA 94720-7360....
HERTWICH Energy and Resources Group University of California Berkeley, CA 94720-3050 WILLIAM S. PEASE Environmental Defense Fund Oakland, CA …