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In vitro and in vivo pharmacology of kratom.
Hiranita T, Obeng S, Sharma A, Wilkerson JL, McCurdy CR, McMahon LR. Hiranita T, et al. Adv Pharmacol. 2022;93:35-76. doi: 10.1016/bs.apha.2021.10.001. Epub 2021 Dec 13. Adv Pharmacol. 2022. PMID: 35341571
Kratom Alkaloids: A Blueprint?
Smith KE, Sharma A, Grundmann O, McCurdy CR. Smith KE, et al. ACS Chem Neurosci. 2023 Jan 18;14(2):195-197. doi: 10.1021/acschemneuro.2c00704. Epub 2023 Jan 3. ACS Chem Neurosci. 2023. PMID: 36594896 Free PMC article.
Directed Biosynthesis of Mitragynine Stereoisomers.
Schotte C, Jiang Y, Grzech D, Dang TT, Laforest LC, León F, Mottinelli M, Nadakuduti SS, McCurdy CR, O'Connor SE. Schotte C, et al. J Am Chem Soc. 2023 Mar 8;145(9):4957-4963. doi: 10.1021/jacs.2c13644. Epub 2023 Feb 22. J Am Chem Soc. 2023. PMID: 36883326 Free PMC article.
Activity of Mitragyna speciosa ("Kratom") Alkaloids at Serotonin Receptors.
León F, Obeng S, Mottinelli M, Chen Y, King TI, Berthold EC, Kamble SH, Restrepo LF, Patel A, Gamez-Jimenez LR, Lopera-Londoño C, Hiranita T, Sharma A, Hampson AJ, Canal CE, McMahon LR, McCurdy CR. León F, et al. J Med Chem. 2021 Sep 23;64(18):13510-13523. doi: 10.1021/acs.jmedchem.1c00726. Epub 2021 Sep 1. J Med Chem. 2021. PMID: 34467758 Free PMC article.
Pharmacological Comparison of Mitragynine and 7-Hydroxymitragynine: In Vitro Affinity and Efficacy for μ-Opioid Receptor and Opioid-Like Behavioral Effects in Rats.
Obeng S, Wilkerson JL, León F, Reeves ME, Restrepo LF, Gamez-Jimenez LR, Patel A, Pennington AE, Taylor VA, Ho NP, Braun T, Fortner JD, Crowley ML, Williamson MR, Pallares VLC, Mottinelli M, Lopera-Londoño C, McCurdy CR, McMahon LR, Hiranita T. Obeng S, et al. J Pharmacol Exp Ther. 2021 Mar;376(3):410-427. doi: 10.1124/jpet.120.000189. Epub 2020 Dec 31. J Pharmacol Exp Ther. 2021. PMID: 33384303 Free PMC article.
38 results