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Quoted phrase not found in phrase index: "Abnormal cardiomyocyte morphology"
Page 1
Integrated multi-omic characterization of congenital heart disease.
Hill MC, Kadow ZA, Long H, Morikawa Y, Martin TJ, Birks EJ, Campbell KS, Nerbonne J, Lavine K, Wadhwa L, Wang J, Turaga D, Adachi I, Martin JF. Hill MC, et al. Nature. 2022 Aug;608(7921):181-191. doi: 10.1038/s41586-022-04989-3. Epub 2022 Jun 22. Nature. 2022. PMID: 35732239 Free PMC article.
The heart, the first organ to develop in the embryo, undergoes complex morphogenesis that when defective results in congenital heart disease (CHD). With current therapies, more than 90% of patients with CHD survive into adulthood, but many suffer premature death from heart …
The heart, the first organ to develop in the embryo, undergoes complex morphogenesis that when defective results in congenital heart …
Arrhythmogenic Cardiomyopathy.
Corrado D, Basso C, Judge DP. Corrado D, et al. Circ Res. 2017 Sep 15;121(7):784-802. doi: 10.1161/CIRCRESAHA.117.309345. Circ Res. 2017. PMID: 28912183 Review.
It is a cell-to-cell junction cardiomyopathy, typically caused by genetically determined abnormalities of cardiac desmosomes, which leads to detachment of myocytes and alteration of intracellular signal transduction. The diagnosis of arrhythmogenic cardiomyop …
It is a cell-to-cell junction cardiomyopathy, typically caused by genetically determined abnormalities of cardiac desmosomes, …
Precise genomic editing of pathogenic mutations in RBM20 rescues dilated cardiomyopathy.
Nishiyama T, Zhang Y, Cui M, Li H, Sanchez-Ortiz E, McAnally JR, Tan W, Kim J, Chen K, Xu L, Bassel-Duby R, Olson EN. Nishiyama T, et al. Sci Transl Med. 2022 Nov 23;14(672):eade1633. doi: 10.1126/scitranslmed.ade1633. Epub 2022 Nov 23. Sci Transl Med. 2022. PMID: 36417486 Free PMC article.
These mutations induce RBM20 mis-localization to form aberrant ribonucleoprotein (RNP) granules in the cytoplasm of cardiomyocytes and abnormal alternative splicing of cardiac genes, contributing to DCM. ...As seen by RNA sequencing analysis, ABE correction r …
These mutations induce RBM20 mis-localization to form aberrant ribonucleoprotein (RNP) granules in the cytoplasm of cardiomyocytes an …
Cardiomyopathies and Adrenal Diseases.
Petramala L, Concistrè A, Olmati F, Saracino V, Chimenti C, Frustaci A, Russo MA, Letizia C. Petramala L, et al. Int J Mol Sci. 2020 Jul 17;21(14):5047. doi: 10.3390/ijms21145047. Int J Mol Sci. 2020. PMID: 32709015 Free PMC article. Review.
Cardiomyopathies are myocardial disorders in which heart muscle is structurally and/or functionally abnormal. Previously, structural cardiomyocyte disorders due to adrenal diseases, such as hyperaldosteronism, hypercortisolism, and hypercatecholaminism, were misunde …
Cardiomyopathies are myocardial disorders in which heart muscle is structurally and/or functionally abnormal. Previously, structural …
Loss of Nuclear Envelope Integrity and Increased Oxidant Production Cause DNA Damage in Adult Hearts Deficient in PKP2: A Molecular Substrate of ARVC.
Pérez-Hernández M, van Opbergen CJM, Bagwan N, Vissing CR, Marrón-Liñares GM, Zhang M, Torres Vega E, Sorrentino A, Drici L, Sulek K, Zhai R, Hansen FB, Christensen AH, Boesgaard S, Gustafsson F, Rossing K, Small EM, Davies MJ, Rothenberg E, Sato PY, Cerrone M, Jensen THL, Qvortrup K, Bundgaard H, Delmar M, Lundby A. Pérez-Hernández M, et al. Circulation. 2022 Sep 13;146(11):851-867. doi: 10.1161/CIRCULATIONAHA.122.060454. Epub 2022 Aug 12. Circulation. 2022. PMID: 35959657 Free PMC article.
METHODS: We describe a comprehensive characterization of the ARVC molecular landscape as determined by high-resolution mass spectrometry, RNA sequencing, and transmission electron microscopy of right ventricular biopsy samples obtained from patients with ARVC with PKP2 mutations …
METHODS: We describe a comprehensive characterization of the ARVC molecular landscape as determined by high-resolution mass spectrometry, RN …
Megamitochondria plasticity: Function transition from adaption to disease.
Shang Y, Li Z, Cai P, Li W, Xu Y, Zhao Y, Xia S, Shao Q, Wang H. Shang Y, et al. Mitochondrion. 2023 Jul;71:64-75. doi: 10.1016/j.mito.2023.06.001. Epub 2023 Jun 3. Mitochondrion. 2023. PMID: 37276954 Free article. Review.
However, in response to metabolic and functional damage, mitochondria can grow in size, resulting in a form of abnormal mitochondrial morphology known as megamitochondria. Megamitochondria are characterized by their considerably larger size, pale matrix, and margina …
However, in response to metabolic and functional damage, mitochondria can grow in size, resulting in a form of abnormal mitochondrial …
The H2Bub1-deposition complex is required for human and mouse cardiogenesis.
Barish S, Berg K, Drozd J, Berglund-Brown I, Khizir L, Wasson LK, Seidman CE, Seidman JG, Chen S, Brueckner M. Barish S, et al. Development. 2023 Dec 1;150(23):dev201899. doi: 10.1242/dev.201899. Epub 2023 Dec 1. Development. 2023. PMID: 38038666 Free PMC article.
We show that the H2Bub1-deposition complex (RNF20-RNF40-UBE2B) is required for mouse cardiogenesis and for differentiation of human iPSCs into cardiomyocytes. Mice with cardiac-specific Rnf20 deletion are embryonic lethal and have abnormal myocardium. ...When …
We show that the H2Bub1-deposition complex (RNF20-RNF40-UBE2B) is required for mouse cardiogenesis and for differentiation of human iPSCs in …
Pulmonary hypertension in children with Down syndrome.
Bush D, Galambos C, Dunbar Ivy D. Bush D, et al. Pediatr Pulmonol. 2021 Mar;56(3):621-629. doi: 10.1002/ppul.24687. Epub 2020 Feb 12. Pediatr Pulmonol. 2021. PMID: 32049444 Review.
The presence of an additional copy of chromosome 21 (trisomy 21) increases the risk of developing PH in children with DS through many mechanisms, including increased hemodynamic stress in those with congenital heart disease, hypoxemia through impaired ventilation to perfus …
The presence of an additional copy of chromosome 21 (trisomy 21) increases the risk of developing PH in children with DS through many mechan …
Structural and functional abnormalities in iron-depleted heart.
Kobak KA, Radwańska M, Dzięgała M, Kasztura M, Josiak K, Banasiak W, Ponikowski P, Jankowska EA. Kobak KA, et al. Heart Fail Rev. 2019 Mar;24(2):269-277. doi: 10.1007/s10741-018-9738-4. Heart Fail Rev. 2019. PMID: 30284070 Free PMC article. Review.
Iron deficiency (ID) is a common and ominous comorbidity in heart failure (HF) and predicts worse outcomes, independently of the presence of anaemia. ...Recently, several transgenic models of cardiac-specific ID have been developed to investigate the influence of ID …
Iron deficiency (ID) is a common and ominous comorbidity in heart failure (HF) and predicts worse outcomes, independently of the pres …
Desmin-related cardiomyopathy: an unfolding story.
McLendon PM, Robbins J. McLendon PM, et al. Am J Physiol Heart Circ Physiol. 2011 Oct;301(4):H1220-8. doi: 10.1152/ajpheart.00601.2011. Epub 2011 Jul 22. Am J Physiol Heart Circ Physiol. 2011. PMID: 21784990 Free PMC article. Review.
The intermediate filament protein desmin is an integral component of the cardiomyocyte and serves to maintain the overall structure and cytoskeletal organization within striated muscle cells. ...Aberrant protein aggregation leads to mitochondrial dysfunction, abnormal …
The intermediate filament protein desmin is an integral component of the cardiomyocyte and serves to maintain the overall structure a …
446 results