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Quoted phrase not found in phrase index: "Combined oxidative phosphorylation deficiency 45"
Page 1
Exercise restores brain insulin sensitivity in sedentary adults who are overweight and obese.
Kullmann S, Goj T, Veit R, Fritsche L, Wagner L, Schneeweiss P, Hoene M, Hoffmann C, Machann J, Niess A, Preissl H, Birkenfeld AL, Peter A, Häring HU, Fritsche A, Moller A, Weigert C, Heni M. Kullmann S, et al. JCI Insight. 2022 Sep 22;7(18):e161498. doi: 10.1172/jci.insight.161498. JCI Insight. 2022. PMID: 36134657 Free PMC article. Clinical Trial.
We aimed to evaluate the effects of an exercise intervention on insulin sensitivity of the brain and how this relates to exercise-induced changes in whole-body metabolism and behavior.METHODSIn this clinical trial, sedentary participants who were overweight and obes …
We aimed to evaluate the effects of an exercise intervention on insulin sensitivity of the brain and how this relates to exercise-induced ch …
Devimistat in Combination with Gemcitabine and Cisplatin in Biliary Tract Cancer: Preclinical Evaluation and Phase Ib Multicenter Clinical Trial (BilT-04).
Mohan A, Griffith KA, Wuchu F, Zhen DB, Kumar-Sinha C, Crysler O, Hsiehchen D, Enzler T, Dippman D, Gunchick V, Achreja A, Animasahun O, Choppara S, Nenwani M, Chinnaiyan AM, Nagrath D, Zalupski MM, Sahai V. Mohan A, et al. Clin Cancer Res. 2023 Jul 5;29(13):2394-2400. doi: 10.1158/1078-0432.CCR-23-0036. Clin Cancer Res. 2023. PMID: 37115501 Free PMC article. Clinical Trial.
PURPOSE: Devimistat (CPI-613) is a novel inhibitor of tumoral mitochondrial metabolism. We investigated the effect of devimistat in vitro and in a phase Ib clinical trial in patients with advanced biliary tract cancer (BTC). ...A phase Ib/II trial was …
PURPOSE: Devimistat (CPI-613) is a novel inhibitor of tumoral mitochondrial metabolism. We investigated the effect of devimistat in v …
The humanin analogue (HNG) alleviates intrauterine adhesions by inhibiting endometrial epithelial cells ferroptosis: a rat model-based study.
Zou L, Huang J, Zhang Q, Mo H, Xia W, Zhu C, Rao M. Zou L, et al. Hum Reprod. 2023 Dec 4;38(12):2422-2432. doi: 10.1093/humrep/dead196. Hum Reprod. 2023. PMID: 37814907
In the second model, 66 rats were equally randomized to the control, IUA, and IUA + humanin analogue (HNG) groups. ...PARTICIPANTS/MATERIALS, SETTING, METHODS: The endometrium was scraped with a surgical spatula, combined with lipopolysaccharide treatment, to establ …
In the second model, 66 rats were equally randomized to the control, IUA, and IUA + humanin analogue (HNG) groups. ...PARTICIPANTS/MA …
Effect of Combined Endurance Training and MitoQ on Cardiac Function and Serum Level of Antioxidants, NO, miR-126, and miR-27a in Hypertensive Individuals.
Masoumi-Ardakani Y, Najafipour H, Nasri HR, Aminizadeh S, Jafari S, Moflehi D. Masoumi-Ardakani Y, et al. Biomed Res Int. 2022 Jan 13;2022:8720661. doi: 10.1155/2022/8720661. eCollection 2022. Biomed Res Int. 2022. PMID: 35071600 Free PMC article. Clinical Trial.
METHODS: In a double-blind randomized clinical trial, 52 male participants (age 40-55 years) were randomly divided into four groups (n = 13) of placebo, MitoQ (20 mg/day, oral), ET (cycle ergometer, moderate intensity, 40-60% VO(2) peak, heart rate 120 …
METHODS: In a double-blind randomized clinical trial, 52 male participants (age 40-55 years) were randomly divid …
A review of research trends in physiological abnormalities in autism spectrum disorders: immune dysregulation, inflammation, oxidative stress, mitochondrial dysfunction and environmental toxicant exposures.
Rossignol DA, Frye RE. Rossignol DA, et al. Mol Psychiatry. 2012 Apr;17(4):389-401. doi: 10.1038/mp.2011.165. Epub 2011 Dec 6. Mol Psychiatry. 2012. PMID: 22143005 Free PMC article. Review.
A large percentage of publications implicated an association between ASD and immune dysregulation/inflammation (416 out of 437 publications, 95%), oxidative stress (all 115), mitochondrial dysfunction (145 of 153, 95%) and toxicant exposures (170 of 190, 89%). ...Th …
A large percentage of publications implicated an association between ASD and immune dysregulation/inflammation (416 out of 437 publications, …
Combined aerobic training and dichloroacetate improve exercise capacity and indices of aerobic metabolism in muscle cytochrome oxidase deficiency.
Taivassalo T, Matthews PM, De Stefano N, Sripathi N, Genge A, Karpati G, Arnold DL. Taivassalo T, et al. Neurology. 1996 Aug;47(2):529-34. doi: 10.1212/wnl.47.2.529. Neurology. 1996. PMID: 8757032
There is no generally effective therapy for mitochondrial myopathies. In this study, we measured responses to combined aerobic training and oral dichloroacetate (DCA) therapy in a 25-year-old woman with a mitochondrial myopathy caused by cytochrome oxidase …
There is no generally effective therapy for mitochondrial myopathies. In this study, we measured responses to combined aerobic …
Network pharmacology and experimental evidence reveal the protective mechanism of Yi-Qi Cong-Ming decoction on age-related hearing loss.
Yang YF, Yan XR, Wu RX, Li N, Chu M, Dong Y, Fu SP, Shi JR, Liu Q. Yang YF, et al. Pharm Biol. 2022 Dec;60(1):1478-1490. doi: 10.1080/13880209.2022.2101671. Pharm Biol. 2022. PMID: 35938504 Free PMC article.
Molecular docking and an in vitro model of ARHL by exposing auditory cells with 100 muM H(2)O(2) for 3 h were applied. Cell viability and mitochondrial membrane potential (deltapsiM) were detected by CCK-8 and high-content analysis. gammaH2AX and cleaved caspase-3 were det …
Molecular docking and an in vitro model of ARHL by exposing auditory cells with 100 muM H(2)O(2) for 3 h were applied. Cell viability and …
Antimyoclonic Effect of Levetiracetam and Clonazepam Combined Treatment on Myoclonic Epilepsy with Ragged-Red Fiber Syndrome with m.8344A>G Mutation.
Su LJ, Wang YL, Han T, Qiao S, Zang KJ, Wu HK, Su YX, Liu LL, Liu XW. Su LJ, et al. Chin Med J (Engl). 2018 Oct 20;131(20):2433-2438. doi: 10.4103/0366-6999.243568. Chin Med J (Engl). 2018. PMID: 30334528 Free PMC article.
METHODS: Treatments of myoclonic seizures with VPA, LEV, CZP, and TPM were reported as monotherapies in 17 MERRF patients from Qilu Hospital between 2003 and 2016, who were diagnosed through clinical data and genetic testing. After 1-4 months of follow-up (mean: 82.9 28.1 …
METHODS: Treatments of myoclonic seizures with VPA, LEV, CZP, and TPM were reported as monotherapies in 17 MERRF patients from Qilu Hospital …
Hyperbaric oxygen increases glioma cell sensitivity to antitumor treatment with a novel isothiourea derivative in vitro.
Zembrzuska K, Ostrowski RP, Matyja E. Zembrzuska K, et al. Oncol Rep. 2019 May;41(5):2703-2716. doi: 10.3892/or.2019.7064. Epub 2019 Mar 14. Oncol Rep. 2019. PMID: 30896865 Free PMC article.
Thus, improved tumor tissue oxygenation may promote greater sensitivity to anticancer treatment. Protein kinase D1 (PKD1) protects cells from oxidative stress, and its abnormal activity serves an important role in multiple malignancies. ...However, there were significant d …
Thus, improved tumor tissue oxygenation may promote greater sensitivity to anticancer treatment. Protein kinase D1 (PKD1) protects cells fro …
Triple therapy with darbepoetin alfa, idebenone, and riboflavin in Friedreich's ataxia: an open-label trial.
Arpa J, Sanz-Gallego I, Rodríguez-de-Rivera FJ, Domínguez-Melcón FJ, Prefasi D, Oliva-Navarro J, Moreno-Yangüela M, Pascual-Pascual SI. Arpa J, et al. Cerebellum. 2013 Oct;12(5):713-20. doi: 10.1007/s12311-013-0482-y. Cerebellum. 2013. PMID: 23625326 Clinical Trial.
The primary objective of the current study was to test the efficacy, safety, and tolerability of triple therapy-darbepoetin alfa, idebenone, and riboflavin-in FRDA in a clinical pilot study. Patients included in this study were nine females, 16 to 45 years of age (a …
The primary objective of the current study was to test the efficacy, safety, and tolerability of triple therapy-darbepoetin alfa, idebenone, …
24 results