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Page 1
Biochemical and molecular teratology of fetal hydantoin syndrome.
Buehler BA, Rao V, Finnell RH. Buehler BA, et al. Neurol Clin. 1994 Nov;12(4):741-8. Neurol Clin. 1994. PMID: 7845340 Review.
In the case of dilantin it appears that fetal susceptibility correlates with the fetal level of the microsomal detoxifying enzyme epoxide hydrolase. The genetics of seizures in the parents does not predict the risk for fetal teratogenesis. The clinician must work with a mo …
In the case of dilantin it appears that fetal susceptibility correlates with the fetal level of the microsomal detoxifying enzyme epoxide hy …
Prenatal prediction of risk of the fetal hydantoin syndrome.
Buehler BA, Delimont D, van Waes M, Finnell RH. Buehler BA, et al. N Engl J Med. 1990 May 31;322(22):1567-72. doi: 10.1056/NEJM199005313222204. N Engl J Med. 1990. PMID: 2336087 Free article.
In a prospective study of 19 pregnancies monitored by amniocentesis, an adverse outcome was predicted for four fetuses on the basis of low enzyme activity (less than 30 percent of the standard). In all four cases, the mother was receiving phenytoin monotherapy, and after b …
In a prospective study of 19 pregnancies monitored by amniocentesis, an adverse outcome was predicted for four fetuses on the basis o …
Minor anomalies in offspring of epileptic mothers.
Gaily E, Granström ML, Hiilesmaa V, Bardy A. Gaily E, et al. J Pediatr. 1988 Apr;112(4):520-9. doi: 10.1016/s0022-3476(88)80162-8. J Pediatr. 1988. PMID: 3351676
There was no excess of other minor anomalies studied. Several minor anomalies previously regarded as typical of fetal hydantoin syndrome were shown to be genetically linked to epilepsy. ...The risk of developmental disturbance associated with intrauterine phe …
There was no excess of other minor anomalies studied. Several minor anomalies previously regarded as typical of fetal hydantoin …
Valproic acid and its metabolites: placental transfer, neonatal pharmacokinetics, transfer via mother's milk and clinical status in neonates of epileptic mothers.
Nau H, Rating D, Koch S, Häuser I, Helge H. Nau H, et al. J Pharmacol Exp Ther. 1981 Dec;219(3):768-77. J Pharmacol Exp Ther. 1981. PMID: 6795343
A number of minor anomalies (four to eight per child) were observed, particularly hernias, diastasis of musculus rectus abdominis and weak abdominal walls. Two children were microcephalic and in another four children the head circumferences were below the 10th percentile. …
A number of minor anomalies (four to eight per child) were observed, particularly hernias, diastasis of musculus rectus abdominis and …
Ganglioneuroblastoma and fetal hydantoin-alcohol syndromes.
Seeler RA, Israel JN, Royal JE, Kaye CI, Rao S, Abulaban M. Seeler RA, et al. Pediatrics. 1979 Apr;63(4):524-7. Pediatrics. 1979. PMID: 440860
Our case, plus two recent reports in the literature, would very likely establish the relationship between fetal hydantoin syndrome and the development of neural crest tumors. Infants exposed in utero to hydantoins should be closely observed for the dev …
Our case, plus two recent reports in the literature, would very likely establish the relationship between fetal hydantoin s …
Clinical and experimental studies linking oxidative metabolism to phenytoin-induced teratogenesis.
Finnell RH, Buehler BA, Kerr BM, Ager PL, Levy RH. Finnell RH, et al. Neurology. 1992 Apr;42(4 Suppl 5):25-31. Neurology. 1992. PMID: 1574173
The clinical aspect involved determining whether at-risk fetuses could be detected prenatally on the basis of low or deficient epoxide hydrolase activity. In 19 pregnancies monitored by amniocentesis, we predicted an adverse outcome in four infants on the basis of low enzy …
The clinical aspect involved determining whether at-risk fetuses could be detected prenatally on the basis of low or deficient epoxide hydro …
Serum folate concentrations during pregnancy in women with epilepsy: relation to antiepileptic drug concentrations, number of seizures, and fetal outcome.
Hiilesmaa VK, Teramo K, Granström ML, Bardy AH. Hiilesmaa VK, et al. Br Med J (Clin Res Ed). 1983 Aug 27;287(6392):577-9. doi: 10.1136/bmj.287.6392.577. Br Med J (Clin Res Ed). 1983. PMID: 6411231 Free PMC article.
No cases of maternal tissue folate deficiency or fetal damage attributable to low maternal serum folate were observed. Maternal serum folate concentrations for infants with structural birth defects, "fetal hydantoin syndrome," or perinatal death were s …
No cases of maternal tissue folate deficiency or fetal damage attributable to low maternal serum folate were observed. Maternal serum …