Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1986 1
1991 2
1993 2
1994 2
1995 11
1996 7
1997 11
1998 8
1999 17
2000 10
2001 18
2002 18
2003 21
2004 48
2005 57
2006 78
2007 58
2008 75
2009 61
2010 81
2011 92
2012 93
2013 91
2014 105
2015 135
2016 109
2017 108
2018 98
2019 113
2020 117
2021 146
2022 161
2023 132
2024 55

Text availability

Article attribute

Article type

Publication date

Search Results

1,902 results

Results by year

Filters applied: . Clear all
Page 1
PARP and PARG inhibitors in cancer treatment.
Slade D. Slade D. Genes Dev. 2020 Mar 1;34(5-6):360-394. doi: 10.1101/gad.334516.119. Epub 2020 Feb 6. Genes Dev. 2020. PMID: 32029455 Free PMC article. Review.
I highlight clinical performance of four PARP inhibitors used in cancer therapy (olaparib, rucaparib, niraparib, and talazoparib) and discuss the predictive biomarkers of inhibitor sensitivity, mechanisms of resistance as well as the means of overcoming them through combin …
I highlight clinical performance of four PARP inhibitors used in cancer therapy (olaparib, rucaparib, niraparib, and talazoparib) and discus …
Epigenetics, DNA damage, and aging.
Soto-Palma C, Niedernhofer LJ, Faulk CD, Dong X. Soto-Palma C, et al. J Clin Invest. 2022 Aug 15;132(16):e158446. doi: 10.1172/JCI158446. J Clin Invest. 2022. PMID: 35968782 Free PMC article. Review.
Over the course of a human lifespan, genome integrity erodes, leading to an increased abundance of several types of chromatin changes. ...
Over the course of a human lifespan, genome integrity erodes, leading to an increased abundance of several types of chromatin changes …
Genomic instability--an evolving hallmark of cancer.
Negrini S, Gorgoulis VG, Halazonetis TD. Negrini S, et al. Nat Rev Mol Cell Biol. 2010 Mar;11(3):220-8. doi: 10.1038/nrm2858. Nat Rev Mol Cell Biol. 2010. PMID: 20177397 Review.
In hereditary cancers, genomic instability results from mutations in DNA repair genes and drives cancer development, as predicted by the mutator hypothesis. In sporadic (non-hereditary) cancers the molecular basis of genomic instability remains unclear, but recent high-thr …
In hereditary cancers, genomic instability results from mutations in DNA repair genes and drives cancer development, as predicted by …
Tumour heterogeneity and resistance to cancer therapies.
Dagogo-Jack I, Shaw AT. Dagogo-Jack I, et al. Nat Rev Clin Oncol. 2018 Feb;15(2):81-94. doi: 10.1038/nrclinonc.2017.166. Epub 2017 Nov 8. Nat Rev Clin Oncol. 2018. PMID: 29115304 Review.
Cancer is a dynamic disease. During the course of disease, cancers generally become more heterogeneous. As a result of this heterogeneity, the bulk tumour might include a diverse collection of cells harbouring distinct molecular signatures with differential levels of sensi …
Cancer is a dynamic disease. During the course of disease, cancers generally become more heterogeneous. As a result of this heterogen …
Neuroblastoma arises in early fetal development and its evolutionary duration predicts outcome.
Körber V, Stainczyk SA, Kurilov R, Henrich KO, Hero B, Brors B, Westermann F, Höfer T. Körber V, et al. Nat Genet. 2023 Apr;55(4):619-630. doi: 10.1038/s41588-023-01332-y. Epub 2023 Mar 27. Nat Genet. 2023. PMID: 36973454 Free PMC article.
We find that tumors across the entire clinical spectrum begin to develop via aberrant mitoses as early as the first trimester of pregnancy. Neuroblastomas with favorable prognosis expand clonally after short evolution, whereas aggressive neuroblastomas show prolonged evolu …
We find that tumors across the entire clinical spectrum begin to develop via aberrant mitoses as early as the first trimester of pregnancy. …
Metagenomic next-generation sequencing to identify pathogens and cancer in lung biopsy tissue.
Guo Y, Li H, Chen H, Li Z, Ding W, Wang J, Yin Y, Jin L, Sun S, Jing C, Wang H. Guo Y, et al. EBioMedicine. 2021 Nov;73:103639. doi: 10.1016/j.ebiom.2021.103639. Epub 2021 Oct 23. EBioMedicine. 2021. PMID: 34700283 Free PMC article.
The neural networks were pretrained by extracting features of human reads from 2,095 metagenomic next-generation sequencing results, and the human reads of lung biopsy samples were entered into the validated pipeline to predict the risk of cancer. FINDINGS: Based on the pa …
The neural networks were pretrained by extracting features of human reads from 2,095 metagenomic next-generation sequencing results, and the …
Cancer: beyond speciation.
Vincent MD. Vincent MD. Adv Cancer Res. 2011;112:283-350. doi: 10.1016/B978-0-12-387688-1.00010-7. Adv Cancer Res. 2011. PMID: 21925308 Review.
The "mutation theory," however, is noticeable for its failure to explain the basis of differential chemosensitivity, for providing a paucity of targets, especially druggable ones, and for justifying the development of targeted therapies with, in general, disappointingly abbreviat …
The "mutation theory," however, is noticeable for its failure to explain the basis of differential chemosensitivity, for providing a paucity …
Electromagnetic Fields, Genomic Instability and Cancer: A Systems Biological View.
Naarala J, Kolehmainen M, Juutilainen J. Naarala J, et al. Genes (Basel). 2019 Jun 25;10(6):479. doi: 10.3390/genes10060479. Genes (Basel). 2019. PMID: 31242701 Free PMC article. Review.
We discuss experimental approaches that can be coupled with theoreticalsystems biology such as testable predictions, derived from the theory and experimental methods,that can be used for measuring the state of the complex biological system. ...
We discuss experimental approaches that can be coupled with theoreticalsystems biology such as testable predictions, derived from the …
Characterization of genomic instability-related genes predicts survival and therapeutic response in lung adenocarcinoma.
Li S, Wang W, Yu H, Zhang S, Bi W, Sun S, Hong B, Fang Z, Chen X. Li S, et al. BMC Cancer. 2023 Nov 16;23(1):1115. doi: 10.1186/s12885-023-11580-0. BMC Cancer. 2023. PMID: 37974107 Free PMC article.
RESULTS: We constructed and validated the GSAGI, consisting of five genes: ANLN, RHOV, KRT6A, SIGLEC6, and KLRG2. The GSAGI was an independent prognostic factor for LUAD patients. Patients in the high-risk group distinguished by the GSAGI are more suitable for chemotherapy …
RESULTS: We constructed and validated the GSAGI, consisting of five genes: ANLN, RHOV, KRT6A, SIGLEC6, and KLRG2. The GSAGI was an independe …
Pan-cancer analysis and experimental validation of DTL as a potential diagnosis, prognosis and immunotherapy biomarker.
Tang Y, Lei Y, Gao P, Jia J, Du H, Wang Q, Yan Z, Zhang C, Liang G, Wang Y, Ma W, Xing N, Cheng L, Ren L. Tang Y, et al. BMC Cancer. 2023 Apr 10;23(1):328. doi: 10.1186/s12885-023-10755-z. BMC Cancer. 2023. PMID: 37038185 Free PMC article.
BACKGROUND: DTL has been found to be related with multiple cancers. However, comprehensive analyses, which identify the prediction value of DTL in diagnosis, prognosis, immune infiltration and treatment, have rarely been reported so far. ...Pan-cancer bioinformatics …
BACKGROUND: DTL has been found to be related with multiple cancers. However, comprehensive analyses, which identify the prediction va …
1,902 results