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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1953 1
1966 1
1968 2
1969 1
1970 3
1971 5
1972 3
1973 3
1974 4
1975 21
1976 24
1977 26
1978 24
1979 30
1980 31
1981 25
1982 35
1983 32
1984 44
1985 46
1986 44
1987 41
1988 39
1989 38
1990 46
1991 45
1992 60
1993 53
1994 70
1995 53
1996 74
1997 70
1998 69
1999 75
2000 105
2001 73
2002 67
2003 93
2004 99
2005 93
2006 90
2007 114
2008 112
2009 125
2010 155
2011 145
2012 131
2013 154
2014 118
2015 156
2016 184
2017 199
2018 199
2019 203
2020 274
2021 284
2022 253
2023 225
2024 94

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4,477 results

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Page 1
Red Blood Cell Transfusion: 2023 AABB International Guidelines.
Carson JL, Stanworth SJ, Guyatt G, Valentine S, Dennis J, Bakhtary S, Cohn CS, Dubon A, Grossman BJ, Gupta GK, Hess AS, Jacobson JL, Kaplan LJ, Lin Y, Metcalf RA, Murphy CH, Pavenski K, Prochaska MT, Raval JS, Salazar E, Saifee NH, Tobian AAR, So-Osman C, Waters J, Wood EM, Zantek ND, Pagano MB. Carson JL, et al. JAMA. 2023 Nov 21;330(19):1892-1902. doi: 10.1001/jama.2023.12914. JAMA. 2023. PMID: 37824153
For pediatric patients, 7 randomized controlled trials with 2730 participants compared a variety of restrictive and liberal transfusion thresholds. ...CONCLUSIONS AND RELEVANCE: It is good practice to consider overall clinical context and alternative therapies to tr …
For pediatric patients, 7 randomized controlled trials with 2730 participants compared a variety of restrictive and liberal transfusi …
The acute respiratory distress syndrome.
Matthay MA, Ware LB, Zimmerman GA. Matthay MA, et al. J Clin Invest. 2012 Aug;122(8):2731-40. doi: 10.1172/JCI60331. Epub 2012 Aug 1. J Clin Invest. 2012. PMID: 22850883 Free PMC article. Review.
The acute respiratory distress syndrome (ARDS) is an important cause of acute respiratory failure that is often associated with multiple organ failure. Several clinical disorders can precipitate ARDS, including pneumonia, sepsis, aspiration of gastric contents, and major t …
The acute respiratory distress syndrome (ARDS) is an important cause of acute respiratory failure that is often associated with multiple org …
Treatment of ARDS With Prone Positioning.
Scholten EL, Beitler JR, Prisk GK, Malhotra A. Scholten EL, et al. Chest. 2017 Jan;151(1):215-224. doi: 10.1016/j.chest.2016.06.032. Epub 2016 Jul 8. Chest. 2017. PMID: 27400909 Free PMC article. Review.
This work elucidated the physiological mechanisms underlying changes in gas exchange and respiratory mechanics with prone ventilation. However, translating physiological improvements into a clinical benefit has proved challenging; several contemporary trials showed no majo …
This work elucidated the physiological mechanisms underlying changes in gas exchange and respiratory mechanics with prone ventilation. Howev …
Prone Positioning for Acute Hypoxemic Respiratory Failure and ARDS: A Review.
Rampon GL, Simpson SQ, Agrawal R. Rampon GL, et al. Chest. 2023 Feb;163(2):332-340. doi: 10.1016/j.chest.2022.09.020. Epub 2022 Sep 23. Chest. 2023. PMID: 36162482 Review.
Initially implemented clinically as an empiric therapy for refractory hypoxemia, multiple clinical trials were performed on the use of prone positioning in various respiratory conditions, cumulating in the landmark Proning Severe ARDS Patients trial, which de …
Initially implemented clinically as an empiric therapy for refractory hypoxemia, multiple clinical trials were performed on th …
The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination.
Bernard GR, Artigas A, Brigham KL, Carlet J, Falke K, Hudson L, Lamy M, Legall JR, Morris A, Spragg R. Bernard GR, et al. Am J Respir Crit Care Med. 1994 Mar;149(3 Pt 1):818-24. doi: 10.1164/ajrccm.149.3.7509706. Am J Respir Crit Care Med. 1994. PMID: 7509706 Review.
The acute respiratory distress syndrome (ARDS), a process of nonhydrostatic pulmonary edema and hypoxemia associated with a variety of etiologies, carries a high morbidity, mortality (10 to 90%), and financial cost. ...Thus, those who wish to know the true incidence and ou …
The acute respiratory distress syndrome (ARDS), a process of nonhydrostatic pulmonary edema and hypoxemia associated with a variety o …
A Randomized Trial of High-Flow Oxygen Therapy in Infants with Bronchiolitis.
Franklin D, Babl FE, Schlapbach LJ, Oakley E, Craig S, Neutze J, Furyk J, Fraser JF, Jones M, Whitty JA, Dalziel SR, Schibler A. Franklin D, et al. N Engl J Med. 2018 Mar 22;378(12):1121-1131. doi: 10.1056/NEJMoa1714855. N Engl J Med. 2018. PMID: 29562151 Free article. Clinical Trial.
The efficacy of high-flow oxygen therapy through a nasal cannula in settings other than intensive care units (ICUs) is unclear. METHODS: In this multicenter, randomized, controlled trial, we assigned infants younger than 12 months of age who had bronchiolitis and a …
The efficacy of high-flow oxygen therapy through a nasal cannula in settings other than intensive care units (ICUs) is unclear. METHODS: In …
Precision Medicine Approach to Alzheimer's Disease: Successful Pilot Project.
Toups K, Hathaway A, Gordon D, Chung H, Raji C, Boyd A, Hill BD, Hausman-Cohen S, Attarha M, Chwa WJ, Jarrett M, Bredesen DE. Toups K, et al. J Alzheimers Dis. 2022;88(4):1411-1421. doi: 10.3233/JAD-215707. J Alzheimers Dis. 2022. PMID: 35811518 Free PMC article. Clinical Trial.
OBJECTIVE: To determine whether a precision medicine approach to Alzheimer's disease and mild cognitive impairment is effective enough in a proof-of-concept trial to warrant a larger, randomized, controlled clinical trial. ...CONCLUSION: Based on the c …
OBJECTIVE: To determine whether a precision medicine approach to Alzheimer's disease and mild cognitive impairment is effective enough in a …
Oxygen Therapy in Suspected Acute Myocardial Infarction.
Hofmann R, James SK, Jernberg T, Lindahl B, Erlinge D, Witt N, Arefalk G, Frick M, Alfredsson J, Nilsson L, Ravn-Fischer A, Omerovic E, Kellerth T, Sparv D, Ekelund U, Linder R, Ekström M, Lauermann J, Haaga U, Pernow J, Östlund O, Herlitz J, Svensson L; DETO2X–SWEDEHEART Investigators. Hofmann R, et al. N Engl J Med. 2017 Sep 28;377(13):1240-1249. doi: 10.1056/NEJMoa1706222. Epub 2017 Aug 28. N Engl J Med. 2017. PMID: 28844200 Free article. Clinical Trial.
BACKGROUND: The clinical effect of routine oxygen therapy in patients with suspected acute myocardial infarction who do not have hypoxemia at baseline is uncertain. METHODS: In this registry-based randomized clinical trial, we used nationwide Sw …
BACKGROUND: The clinical effect of routine oxygen therapy in patients with suspected acute myocardial infarction who do not have h …
Effect of High-Flow Oxygen Therapy vs Conventional Oxygen Therapy on Invasive Mechanical Ventilation and Clinical Recovery in Patients With Severe COVID-19: A Randomized Clinical Trial.
Ospina-Tascón GA, Calderón-Tapia LE, García AF, Zarama V, Gómez-Álvarez F, Álvarez-Saa T, Pardo-Otálvaro S, Bautista-Rincón DF, Vargas MP, Aldana-Díaz JL, Marulanda Á, Gutiérrez A, Varón J, Gómez M, Ochoa ME, Escobar E, Umaña M, Díez J, Tobón GJ, Albornoz LL, Celemín Flórez CA, Ruiz GO, Cáceres EL, Reyes LF, Damiani LP, Cavalcanti AB; HiFLo-Covid Investigators. Ospina-Tascón GA, et al. JAMA. 2021 Dec 7;326(21):2161-2171. doi: 10.1001/jama.2021.20714. JAMA. 2021. PMID: 34874419 Free PMC article. Clinical Trial.
OBJECTIVE: To determine the effect of high-flow oxygen therapy through a nasal cannula compared with conventional oxygen therapy on need for endotracheal intubation and clinical recovery in severe COVID-19. DESIGN, SETTING, AND PARTICIPANTS: Randomized, open-label …
OBJECTIVE: To determine the effect of high-flow oxygen therapy through a nasal cannula compared with conventional oxygen therapy on need for …
Effect of Awake Prone Positioning on Endotracheal Intubation in Patients With COVID-19 and Acute Respiratory Failure: A Randomized Clinical Trial.
Alhazzani W, Parhar KKS, Weatherald J, Al Duhailib Z, Alshahrani M, Al-Fares A, Buabbas S, Cherian SV, Munshi L, Fan E, Al-Hameed F, Chalabi J, Rahmatullah AA, Duan E, Tsang JLY, Lewis K, Lauzier F, Centofanti J, Rochwerg B, Culgin S, Nelson K, Abdukahil SA, Fiest KM, Stelfox HT, Tlayjeh H, Meade MO, Perri D, Solverson K, Niven DJ, Lim R, Møller MH, Belley-Cote E, Thabane L, Tamim H, Cook DJ, Arabi YM; COVI-PRONE Trial Investigators and the Saudi Critical Care Trials Group. Alhazzani W, et al. JAMA. 2022 Jun 7;327(21):2104-2113. doi: 10.1001/jama.2022.7993. JAMA. 2022. PMID: 35569448 Free PMC article. Clinical Trial.
DESIGN, SETTING, AND PARTICIPANTS: Pragmatic, unblinded randomized clinical trial conducted at 21 hospitals in Canada, Kuwait, Saudi Arabia, and the US. ...RESULTS: Among the 400 patients who were randomized (mean age, 57.6 years [SD, 12.83 years]; 117 …
DESIGN, SETTING, AND PARTICIPANTS: Pragmatic, unblinded randomized clinical trial conducted at 21 hospitals in Canada, …
4,477 results