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106 results

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Page 1
Idiopathic Hypersomnia and Other Hypersomnia Syndromes.
Trotti LM, Arnulf I. Trotti LM, et al. Neurotherapeutics. 2021 Jan;18(1):20-31. doi: 10.1007/s13311-020-00919-1. Neurotherapeutics. 2021. PMID: 32901432 Free PMC article. Review.
There are numerous disorders of known or presumed neurologic origin that result in excessive daytime sleepiness, collectively known as the central disorders of hypersomnolence. These include narcolepsy types 1 and 2, idiopathic hypersomnia, Kleine-Levin syndrome, an …
There are numerous disorders of known or presumed neurologic origin that result in excessive daytime sleepiness, collectively known as the c …
Update on the treatment of idiopathic hypersomnia: Progress, challenges, and expert opinion.
Arnulf I, Thomas R, Roy A, Dauvilliers Y. Arnulf I, et al. Sleep Med Rev. 2023 Jun;69:101766. doi: 10.1016/j.smrv.2023.101766. Epub 2023 Feb 25. Sleep Med Rev. 2023. PMID: 36921459 Free article. Review.
Modafinil, which was approved for idiopathic hypersomnia until 2011 in Europe, is the most commonly used treatment and improved sleepiness in two recent randomized placebo-controlled trials. ...Continued research on idiopathic hypersomnia is nee …
Modafinil, which was approved for idiopathic hypersomnia until 2011 in Europe, is the most commonly used treatment and improve …
European guideline and expert statements on the management of narcolepsy in adults and children.
Bassetti CLA, Kallweit U, Vignatelli L, Plazzi G, Lecendreux M, Baldin E, Dolenc-Groselj L, Jennum P, Khatami R, Manconi M, Mayer G, Partinen M, Pollmächer T, Reading P, Santamaria J, Sonka K, Dauvilliers Y, Lammers GJ. Bassetti CLA, et al. J Sleep Res. 2021 Dec;30(6):e13387. doi: 10.1111/jsr.13387. Epub 2021 Jun 25. J Sleep Res. 2021. PMID: 34173288 Free article. Review.
METHODS: The European Academy of Neurology (EAN), European Sleep Research Society (ESRS), and European Narcolepsy Network (EU-NN) nominated a task force of 18 narcolepsy specialists. According to the EAN recommendations, 10 relevant clinical questions were formulated in PI …
METHODS: The European Academy of Neurology (EAN), European Sleep Research Society (ESRS), and European Narcolepsy Network (EU-NN) nominated …
Idiopathic Hypersomnia.
Trotti LM. Trotti LM. Sleep Med Clin. 2017 Sep;12(3):331-344. doi: 10.1016/j.jsmc.2017.03.009. Epub 2017 Jun 16. Sleep Med Clin. 2017. PMID: 28778232 Free PMC article. Review.
Idiopathic hypersomnia (IH) is a chronic neurologic disorder of daytime sleepiness, accompanied by long sleep times, unrefreshing sleep, difficulty in awakening, cognitive dysfunction, and autonomic symptoms. ...Autonomic, inflammatory, or immune dysfunction has bee …
Idiopathic hypersomnia (IH) is a chronic neurologic disorder of daytime sleepiness, accompanied by long sleep times, unrefresh …
Idiopathic hypersomnia.
Billiard M, Sonka K. Billiard M, et al. Sleep Med Rev. 2016 Oct;29:23-33. doi: 10.1016/j.smrv.2015.08.007. Epub 2015 Sep 3. Sleep Med Rev. 2016. PMID: 26599679 Review.
Idiopathic hypersomnia continues to evolve from the concept of "sleep drunkenness" introduced by Bedrich Roth in Prague in 1956 and the description of idiopathic hypersomnia with two forms, polysymptomatic and monosymptomatic, by the same Bedrich Roth …
Idiopathic hypersomnia continues to evolve from the concept of "sleep drunkenness" introduced by Bedrich Roth in Prague in 195 …
European guideline and expert statements on the management of narcolepsy in adults and children.
Bassetti CLA, Kallweit U, Vignatelli L, Plazzi G, Lecendreux M, Baldin E, Dolenc-Groselj L, Jennum P, Khatami R, Manconi M, Mayer G, Partinen M, Pollmächer T, Reading P, Santamaria J, Sonka K, Dauvilliers Y, Lammers GJ. Bassetti CLA, et al. Eur J Neurol. 2021 Sep;28(9):2815-2830. doi: 10.1111/ene.14888. Epub 2021 Jun 25. Eur J Neurol. 2021. PMID: 34173695 Free article.
METHODS: The European Academy of Neurology (EAN), European Sleep Research Society (ESRS) and European Narcolepsy Network (EU-NN) nominated a task force of 18 narcolepsy specialists. According to the EAN recommendations, 10 relevant clinical questions were formulated in PIC …
METHODS: The European Academy of Neurology (EAN), European Sleep Research Society (ESRS) and European Narcolepsy Network (EU-NN) nominated a …
Once-nightly sodium oxybate (FT218) demonstrated improvement of symptoms in a phase 3 randomized clinical trial in patients with narcolepsy.
Kushida CA, Shapiro CM, Roth T, Thorpy MJ, Corser BC, Ajayi AO, Rosenberg R, Roy A, Seiden D, Dubow J, Dauvilliers Y. Kushida CA, et al. Sleep. 2022 Jun 13;45(6):zsab200. doi: 10.1093/sleep/zsab200. Sleep. 2022. PMID: 34358324 Free PMC article. Clinical Trial.
Secondary endpoints included change from baseline on the Epworth Sleepiness Scale. Safety included adverse drug reactions and clinical laboratory assessments. RESULTS: In total, 222 patients were randomized; 212 received 1 dose of ON-SXB (n = 107) or placebo (n = 10 …
Secondary endpoints included change from baseline on the Epworth Sleepiness Scale. Safety included adverse drug reactions and clinical …
Pharmacologic Management of Excessive Daytime Sleepiness.
Takenoshita S, Nishino S. Takenoshita S, et al. Sleep Med Clin. 2020 Jun;15(2):177-194. doi: 10.1016/j.jsmc.2020.02.006. Sleep Med Clin. 2020. PMID: 32386693 Review.
According to the International Classification of Sleep Disorders, Third Edition, diseases that result from EDS are narcolepsy type 1, narcolepsy type 2, idiopathic hypersomnia, hypersomnia due to a medical disorder, and others. ...
According to the International Classification of Sleep Disorders, Third Edition, diseases that result from EDS are narcolepsy type 1, narcol …
Precision Medicine for Idiopathic Hypersomnia.
Arnulf I, Leu-Semenescu S, Dodet P. Arnulf I, et al. Sleep Med Clin. 2019 Sep;14(3):333-350. doi: 10.1016/j.jsmc.2019.05.007. Sleep Med Clin. 2019. PMID: 31375202 Review.
Idiopathic hypersomnia (IH) is characterized by excessive daytime sleepiness despite normal or prolonged sleep. ...
Idiopathic hypersomnia (IH) is characterized by excessive daytime sleepiness despite normal or prolonged sleep. ...
Safety and efficacy of pitolisant in children aged 6 years or older with narcolepsy with or without cataplexy: a double-blind, randomised, placebo-controlled trial.
Dauvilliers Y, Lecendreux M, Lammers GJ, Franco P, Poluektov M, Caussé C, Lecomte I, Lecomte JM, Lehert P, Schwartz JC, Plazzi G. Dauvilliers Y, et al. Lancet Neurol. 2023 Apr;22(4):303-311. doi: 10.1016/S1474-4422(23)00036-4. Lancet Neurol. 2023. PMID: 36931805 Clinical Trial.
Randomisation was stratified by study centre and treatment was allocated using an interactive web response system. ...FINDINGS: Between June 6, 2016, and April 3, 2021, we screened 115 participants and 110 were randomly assigned (mean age 12.9 [SD 3.0] years, 61 [55 …
Randomisation was stratified by study centre and treatment was allocated using an interactive web response system. ...FINDINGS: Betwe …
106 results