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Quoted phrase not found in phrase index: "Leber optic atrophy and dystonia"
Page 1
Mitochondrial Disorders.
Klopstock T, Priglinger C, Yilmaz A, Kornblum C, Distelmaier F, Prokisch H. Klopstock T, et al. Dtsch Arztebl Int. 2021 Nov 5;118(44):741-748. doi: 10.3238/arztebl.m2021.0251. Dtsch Arztebl Int. 2021. PMID: 34158150 Free PMC article. Review.
The only disease-modifying treatment that has been approved to date is idebenone for the treatment of Leber hereditary optic neuropathy. Intravitreal gene therapy has also been developed for the treatment of this disease; its approval by the European Medicine …
The only disease-modifying treatment that has been approved to date is idebenone for the treatment of Leber hereditary opti …
Randomized trial of bilateral gene therapy injection for m.11778G>A MT-ND4 Leber optic neuropathy.
Newman NJ, Yu-Wai-Man P, Subramanian PS, Moster ML, Wang AG, Donahue SP, Leroy BP, Carelli V, Biousse V, Vignal-Clermont C, Sergott RC, Sadun AA, Rebolleda Fernández G, Chwalisz BK, Banik R, Bazin F, Roux M, Cox ED, Taiel M, Sahel JA; LHON REFLECT Study Group. Newman NJ, et al. Brain. 2023 Apr 19;146(4):1328-1341. doi: 10.1093/brain/awac421. Brain. 2023. PMID: 36350566 Free PMC article. Clinical Trial.
Leber hereditary optic neuropathy (LHON) is an important example of mitochondrial blindness with the m.11778G>A mutation in the MT-ND4 gene being the most common disease-causing mtDNA variant worldwide. ...
Leber hereditary optic neuropathy (LHON) is an important example of mitochondrial blindness with the m.11778G>A muta …
Mitochondrial Membrane Dynamics and Inherited Optic Neuropathies.
Bagli E, Zikou AK, Agnantis N, Kitsos G. Bagli E, et al. In Vivo. 2017 Jul-Aug;31(4):511-525. doi: 10.21873/invivo.11090. In Vivo. 2017. PMID: 28652416 Free PMC article. Review.
Inherited optic neuropathies are a genetically diverse group of disorders mainly characterized by visual loss and optic atrophy. Since the first recognition of Leber's hereditary optic neuropathy, several genetic defects altering primary …
Inherited optic neuropathies are a genetically diverse group of disorders mainly characterized by visual loss and optic atr …
Leber hereditary optic neuropathy: new and emerging therapies.
Davila-Siliezar P, Carter M, Milea D, Lee AG. Davila-Siliezar P, et al. Curr Opin Ophthalmol. 2022 Nov 1;33(6):574-578. doi: 10.1097/ICU.0000000000000891. Epub 2022 Aug 24. Curr Opin Ophthalmol. 2022. PMID: 36066375 Review.
PURPOSE OF REVIEW: To review recent therapeutic advances in Leber hereditary optic neuropathy (LHON). RECENT FINDINGS: Idebenone, a synthetic analog of ubiquinone (Coenzyme Q10) is an antioxidant and component of the mitochondrial electron transport chain. .. …
PURPOSE OF REVIEW: To review recent therapeutic advances in Leber hereditary optic neuropathy (LHON). RECENT FINDINGS: …
Therapeutic Approaches to Inherited Optic Neuropathies.
Yu-Wai-Man P. Yu-Wai-Man P. Semin Neurol. 2015 Oct;35(5):578-86. doi: 10.1055/s-0035-1563574. Epub 2015 Oct 6. Semin Neurol. 2015. PMID: 26444403 Review.
As a group, inherited optic neuropathies represent an important cause of severe irreversible visual loss among children and young adults. Leber hereditary optic neuropathy (LHON) and autosomal dominant optic atrophy (DOA) are the two most …
As a group, inherited optic neuropathies represent an important cause of severe irreversible visual loss among children and young adu …
Toxic medications in Leber's hereditary optic neuropathy.
Kogachi K, Ter-Zakarian A, Asanad S, Sadun A, Karanjia R. Kogachi K, et al. Mitochondrion. 2019 May;46:270-277. doi: 10.1016/j.mito.2018.07.007. Epub 2018 Aug 4. Mitochondrion. 2019. PMID: 30081212 Review.
Leber's hereditary optic neuropathy (LHON) is a maternally inherited mitochondrial disorder characterized by acute bilateral vision loss. ...
Leber's hereditary optic neuropathy (LHON) is a maternally inherited mitochondrial disorder characterized by acute bila …
The pathological mechanisms and novel therapeutics for Leber's hereditary optic neuropathy.
Yang YP, Foustine S, Hsiao YJ, Tsai ET, Tsai FT, Wang CL, Ko YL, Tai HY, Tsai YC, Yang CH, Fu YJ, Wang AG, Chien Y. Yang YP, et al. J Chin Med Assoc. 2023 Jun 1;86(6):539-541. doi: 10.1097/JCMA.0000000000000927. Epub 2023 Apr 10. J Chin Med Assoc. 2023. PMID: 37027535
Optic neuropathies were estimated to affect 115 in 100,000 population in 2018. Leber's Hereditary Optic Neuropathy (LHON) as one of such optic neuropathy diseases that was first identified in 1871 and can be defined as a hereditary mitoch …
Optic neuropathies were estimated to affect 115 in 100,000 population in 2018. Leber's Hereditary Optic Neuropat …
A neurodegenerative perspective on mitochondrial optic neuropathies.
Yu-Wai-Man P, Votruba M, Burté F, La Morgia C, Barboni P, Carelli V. Yu-Wai-Man P, et al. Acta Neuropathol. 2016 Dec;132(6):789-806. doi: 10.1007/s00401-016-1625-2. Epub 2016 Sep 30. Acta Neuropathol. 2016. PMID: 27696015 Free PMC article. Review.
Mitochondrial optic neuropathies constitute an important cause of chronic visual morbidity and registrable blindness in both the paediatric and adult population. It is a genetically heterogeneous group of disorders caused by both mitochondrial DNA (mtDNA) mutations and a g …
Mitochondrial optic neuropathies constitute an important cause of chronic visual morbidity and registrable blindness in both the paed …
Movement disorders in mitochondrial diseases.
Tranchant C, Anheim M. Tranchant C, et al. Rev Neurol (Paris). 2016 Aug-Sep;172(8-9):524-529. doi: 10.1016/j.neurol.2016.07.003. Epub 2016 Jul 28. Rev Neurol (Paris). 2016. PMID: 27476418 Review.
Myoclonus is a key feature of MERFF, but may also be encountered in mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS), ARCA2, POLG1 mutations and Leigh syndrome. Dystonia is common in Leigh syndrome (which may be caused by 75 different genes …
Myoclonus is a key feature of MERFF, but may also be encountered in mitochondrial encephalomyopathy, lactic acidosis and stroke-like episode …
The epidemiology and mutation types of Leber's hereditary optic neuropathy in Thailand.
Sathianvichitr K, Sigkaman B, Chirapapaisan N, Laowanapiban P, Padungkiatsagul T, Apinyawasisuk S, Witthayaweerasak J, Chuenkongkaew W. Sathianvichitr K, et al. Ann Med. 2022 Dec;54(1):1601-1607. doi: 10.1080/07853890.2022.2082517. Ann Med. 2022. PMID: 35723074 Free PMC article.
PURPOSE: Leber's hereditary optic neuropathy (LHON), the most common mitochondrial optic neuropathy, causes visual loss, especially in young adults. ...
PURPOSE: Leber's hereditary optic neuropathy (LHON), the most common mitochondrial optic neuropathy, causes visu …
309 results