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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1967 1
1972 1
1973 3
1974 1
1975 1
1976 6
1977 7
1978 5
1979 4
1980 11
1981 10
1982 9
1983 8
1984 10
1985 10
1986 17
1987 15
1988 16
1989 20
1990 17
1991 22
1992 17
1993 29
1994 18
1995 33
1996 26
1997 26
1998 24
1999 31
2000 22
2001 22
2002 24
2003 23
2004 35
2005 27
2006 35
2007 20
2008 35
2009 26
2010 32
2011 46
2012 38
2013 37
2014 56
2015 48
2016 50
2017 57
2018 75
2019 69
2020 77
2021 70
2022 64
2023 61
2024 22

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1,327 results

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Page 1
Aminoglycoside- and Cisplatin-Induced Ototoxicity: Mechanisms and Otoprotective Strategies.
Kros CJ, Steyger PS. Kros CJ, et al. Cold Spring Harb Perspect Med. 2019 Nov 1;9(11):a033548. doi: 10.1101/cshperspect.a033548. Cold Spring Harb Perspect Med. 2019. PMID: 30559254 Free PMC article. Review.
Ototoxicity refers to damage of inner ear structures (i.e., the cochlea and vestibule) and their function (hearing and balance) following exposure to specific in-hospital medications (i.e., aminoglycoside antibiotics, platinum-based drugs), as well as a variety of environm …
Ototoxicity refers to damage of inner ear structures (i.e., the cochlea and vestibule) and their function (hearing and balance) follo …
Aminoglycoside-induced ototoxicity.
Selimoglu E. Selimoglu E. Curr Pharm Des. 2007;13(1):119-26. doi: 10.2174/138161207779313731. Curr Pharm Des. 2007. PMID: 17266591 Review.
Two mutations in the mitochondrial 12S ribosomal RNA gene have been previously reported to predispose carriers to aminoglycoside-induced ototoxicity. As aminoglycosides are indispensable agents both in the treatment of infections and Meniere's disease, a great effort has b …
Two mutations in the mitochondrial 12S ribosomal RNA gene have been previously reported to predispose carriers to aminoglycoside-induced …
Drug-Induced Ototoxicity: A Comprehensive Review and Reference Guide.
Rizk HG, Lee JA, Liu YF, Endriukaitis L, Isaac JL, Bullington WM. Rizk HG, et al. Pharmacotherapy. 2020 Dec;40(12):1265-1275. doi: 10.1002/phar.2478. Epub 2020 Nov 18. Pharmacotherapy. 2020. PMID: 33080070 Review.
OBJECTIVE: In an era of increasing polypharmacy, adverse drug effects such as ototoxicity have significant public health implications. Despite the availability of evidence, many health care professionals may not know the risk of ototoxicity in common medications. .. …
OBJECTIVE: In an era of increasing polypharmacy, adverse drug effects such as ototoxicity have significant public health implications …
Aminoglycoside Vestibulotoxicity.
Rutka J. Rutka J. Adv Otorhinolaryngol. 2019;82:101-110. doi: 10.1159/000490277. Epub 2019 Jan 15. Adv Otorhinolaryngol. 2019. PMID: 30947191 Review.
Many pharmaceuticals have ototoxicity (both cochlear and/or vestibular) as part of their adverse medication profile. ...Commercially available ototopical aminoglycoside preparations for the treatment of external/middle ear disease in the presence of a tympanic membrane def …
Many pharmaceuticals have ototoxicity (both cochlear and/or vestibular) as part of their adverse medication profile. ...Commercially …
Hearing and Other Neurologic Problems.
Landier W, Cohn RJ, van den Heuvel-Eibrink MM. Landier W, et al. Pediatr Clin North Am. 2020 Dec;67(6):1219-1235. doi: 10.1016/j.pcl.2020.07.012. Epub 2020 Sep 23. Pediatr Clin North Am. 2020. PMID: 33131543 Review.
Ototoxicity and other neurologic toxicities are potential consequences of exposure to common therapeutic agents used during treatment of childhood cancer, including platinum and vinca alkaloid chemotherapy, cranial radiation, surgery involving structures critical to cochle …
Ototoxicity and other neurologic toxicities are potential consequences of exposure to common therapeutic agents used during treatment …
Understanding platinum-induced ototoxicity.
Langer T, am Zehnhoff-Dinnesen A, Radtke S, Meitert J, Zolk O. Langer T, et al. Trends Pharmacol Sci. 2013 Aug;34(8):458-69. doi: 10.1016/j.tips.2013.05.006. Epub 2013 Jun 13. Trends Pharmacol Sci. 2013. PMID: 23769626 Review.
However, the antitumor efficacy of cisplatin and carboplatin comes at the cost of ototoxicity, which affects at least 60% of pediatric patients. Although ototoxicity is not life threatening, it can have debilitating effects on patients' quality of life. ...Genetic a …
However, the antitumor efficacy of cisplatin and carboplatin comes at the cost of ototoxicity, which affects at least 60% of pediatri …
Monitoring neonates for ototoxicity.
Garinis AC, Kemph A, Tharpe AM, Weitkamp JH, McEvoy C, Steyger PS. Garinis AC, et al. Int J Audiol. 2018 Sep;57(sup4):S41-S48. doi: 10.1080/14992027.2017.1339130. Epub 2017 Jun 22. Int J Audiol. 2018. PMID: 28949262 Free PMC article. Review.
DESIGN: Here we review current practice and discuss the feasibility of designing improved ototoxicity screening and monitoring protocols to better identify acquired, drug-induced hearing loss in NICU neonates. ...CONCLUSIONS: We conclude that current audiological screening …
DESIGN: Here we review current practice and discuss the feasibility of designing improved ototoxicity screening and monitoring protoc …
Ototoxicity and cancer therapy.
Landier W. Landier W. Cancer. 2016 Jun 1;122(11):1647-58. doi: 10.1002/cncr.29779. Epub 2016 Feb 9. Cancer. 2016. PMID: 26859792 Free article. Review.
The impact of ototoxicity on subsequent health-related and psychosocial outcomes in these patients can be substantial, and the burden of morbidity related to ototoxic agents is particularly high in very young children. Considerable interindividual variability in the preval …
The impact of ototoxicity on subsequent health-related and psychosocial outcomes in these patients can be substantial, and the burden …
Aminoglycoside ototoxicity.
Lerner SA, Matz GJ. Lerner SA, et al. Am J Otolaryngol. 1980 Feb;1(2):169-79. doi: 10.1016/s0196-0709(80)80012-3. Am J Otolaryngol. 1980. PMID: 6969550
The use of these potent antibacterial agents is limited by the risks of ototoxicity and nephrotoxicity. Aminoglycosides are excreted by glomerular filtration at a rate proportional to the serum concentration. ...Utilizing information about aminoglycoside pharmacokinetics, …
The use of these potent antibacterial agents is limited by the risks of ototoxicity and nephrotoxicity. Aminoglycosides are excreted …
Identifying targets to prevent aminoglycoside ototoxicity.
Kim J, Hemachandran S, Cheng AG, Ricci AJ. Kim J, et al. Mol Cell Neurosci. 2022 May;120:103722. doi: 10.1016/j.mcn.2022.103722. Epub 2022 Mar 24. Mol Cell Neurosci. 2022. PMID: 35341941 Free PMC article. Review.
Aminoglycosides are potent antibiotics that are commonly prescribed worldwide. Their use carries significant risks of ototoxicity by directly causing inner ear hair cell degeneration. Despite their ototoxic side effects, there are currently no approved antidotes. Here we r …
Aminoglycosides are potent antibiotics that are commonly prescribed worldwide. Their use carries significant risks of ototoxicity by …
1,327 results