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Year Number of Results
2007 1
2009 3
2010 1
2011 1
2012 1
2013 2
2014 1
2015 3
2016 3
2017 1
2018 1
2019 2
2021 1
2022 2
2023 3
2024 4

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22 results

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Page 1
PTEN Deficiency Facilitates Exosome Secretion and Metastasis in Cholangiocarcinoma by Impairing TFEB-mediated Lysosome Biogenesis.
Jiang TY, Shi YY, Cui XW, Pan YF, Lin YK, Feng XF, Ding ZW, Yang C, Tan YX, Dong LW, Wang HY. Jiang TY, et al. Gastroenterology. 2023 Mar;164(3):424-438. doi: 10.1053/j.gastro.2022.11.025. Epub 2022 Nov 25. Gastroenterology. 2023. PMID: 36436593
TFEB agonist curcumin analog C1 restrained the metastatic phenotype caused by PTEN deficiency in mouse models, and we highlighted the correlation between PTEN deficiency and exosome secretion in clinical cohorts. CONCLUSIONS: In CCA, PTEN def …
TFEB agonist curcumin analog C1 restrained the metastatic phenotype caused by PTEN deficiency in mouse models, and we highligh …
PTEN deficiency exposes a requirement for an ARF GTPase module for integrin-dependent invasion in ovarian cancer.
Nikolatou K, Sandilands E, Román-Fernández A, Cumming EM, Freckmann E, Lilla S, Buetow L, McGarry L, Neilson M, Shaw R, Strachan D, Miller C, Huang DT, McNeish IA, Norman JC, Zanivan S, Bryant DM. Nikolatou K, et al. EMBO J. 2023 Sep 18;42(18):e113987. doi: 10.15252/embj.2023113987. Epub 2023 Aug 14. EMBO J. 2023. PMID: 37577760 Free PMC article.
We here utilise time-lapse imaging of HGSOC spheroids coupled to a machine learning approach to classify the phenotype of PTEN loss. PTEN deficiency induces PI(3,4,5)P(3) -rich and -dependent membrane protrusions into the extracellular matrix (ECM), resulting in a c …
We here utilise time-lapse imaging of HGSOC spheroids coupled to a machine learning approach to classify the phenotype of PTEN loss. PTEN …
PTEN deficiency potentiates HBV-associated liver cancer development through augmented GP73/GOLM1.
Huang F, Guo J, Zhao N, Hou M, Gai X, Yang S, Cai P, Wang Y, Ma Q, Zhao Q, Li L, Yang H, Jing Y, Jin D, Hu Z, Zha X, Wang H, Mao Y, Liu F, Zhang H. Huang F, et al. J Transl Med. 2024 Mar 8;22(1):254. doi: 10.1186/s12967-024-04976-4. J Transl Med. 2024. PMID: 38459588 Free PMC article.
Since phosphatase and tensin homolog (PTEN) is decreased in approximately half of liver cancers, we investigated the significance of PTEN deficiency in HBV-related hepatocarcinogenesis. METHODS: HBV-positive human liver cancer tissues were checked for PTEN expressio …
Since phosphatase and tensin homolog (PTEN) is decreased in approximately half of liver cancers, we investigated the significance of PTEN …
Evolving novel anti-HER2 strategies.
Jones KL, Buzdar AU. Jones KL, et al. Lancet Oncol. 2009 Dec;10(12):1179-87. doi: 10.1016/S1470-2045(09)70315-8. Lancet Oncol. 2009. PMID: 19959074 Review.
Potential mechanisms of resistance to trastuzumab include bypass mechanisms, mutations of the HER2 target, masking of HER2 proteins, inhibition of insulin-like growth factor, and phosphatase and tensin homologue (PTEN) deficiency. Many therapies are being developed …
Potential mechanisms of resistance to trastuzumab include bypass mechanisms, mutations of the HER2 target, masking of HER2 proteins, inhibit …
Cerebellar phenotypes in germline PTEN mutation carriers.
Gambini D, Ferrero S, Bulfamante G, Pisani L, Corbo M, Kuhn E. Gambini D, et al. Neuropathol Appl Neurobiol. 2024 Apr;50(2):e12970. doi: 10.1111/nan.12970. Neuropathol Appl Neurobiol. 2024. PMID: 38504418 Review.
In this review, we summarise the range of cerebellar involvement observed in PHTS and its relationships with germline PTEN mutations, along with the phenotypes expressed by murine models with PTEN deficiency in cerebellar tissue....
In this review, we summarise the range of cerebellar involvement observed in PHTS and its relationships with germline PTEN mutations, along …
Dietary Pterostilbene for MTA1-Targeted Interception in High-Risk Premalignant Prostate Cancer.
Hemani R, Patel I, Inamdar N, Campanelli G, Donovan V, Kumar A, Levenson AS. Hemani R, et al. Cancer Prev Res (Phila). 2022 Feb;15(2):87-100. doi: 10.1158/1940-6207.CAPR-21-0242. Epub 2021 Oct 21. Cancer Prev Res (Phila). 2022. PMID: 34675064 Free PMC article.
We show that MTA1 promotes neoplastic transformation of prostate epithelial cells by activating cell proliferation and survival, leading to PIN development. Moreover, MTA1 cooperates with PTEN deficiency to accelerate PIN development by increasing cell proliferation …
We show that MTA1 promotes neoplastic transformation of prostate epithelial cells by activating cell proliferation and survival, leading to …
Head and neck cancer stem cell maintenance relies on mTOR signaling, specifically involving the mechanistic target of rapamycin complexes 1 and 2 (mTORC1 and mTORC2).
Almeida LO, Silva LC, Emerick C, Amorim Dos Santos J, Castilho RM, Squarize CH. Almeida LO, et al. Arch Oral Biol. 2024 Jan;157:105840. doi: 10.1016/j.archoralbio.2023.105840. Epub 2023 Nov 1. Arch Oral Biol. 2024. PMID: 37939517
In this study, we investigate the response of CSCs to phosphatase and tensin homolog (PTEN) modulation and its potential dependency on the mammalian target of rapamycin (mTOR) signaling. DESIGN: PTEN deficiency was stably induced using short hairpin RNA (shRNA). ... …
In this study, we investigate the response of CSCs to phosphatase and tensin homolog (PTEN) modulation and its potential dependency on the m …
Vitamin D3 suppresses morphological evolution of the cribriform cancerous phenotype.
Deevi RK, McClements J, McCloskey KD, Fatehullah A, Tkocz D, Javadi A, Higginson R, Marsh Durban V, Jansen M, Clarke A, Loughrey MB, Campbell FC. Deevi RK, et al. Oncotarget. 2016 Aug 2;7(31):49042-49064. doi: 10.18632/oncotarget.8863. Oncotarget. 2016. PMID: 27119498 Free PMC article.
Collectively, these events promoted "Swiss cheese-like" cribriform morphology (CM) comprising multiple abnormal "back to back" lumens surrounded by atypical stratified epithelium, in 3D colorectal gland models. Intestinal cancer driven purely by PTEN-deficiency in t …
Collectively, these events promoted "Swiss cheese-like" cribriform morphology (CM) comprising multiple abnormal "back to back" lumens surrou …
Intracellular delivery of the PTEN protein using cationic lipidoids for cancer therapy.
Altınoğlu SA, Wang M, Li KQ, Li Y, Xu Q. Altınoğlu SA, et al. Biomater Sci. 2016 Nov 15;4(12):1773-1780. doi: 10.1039/c6bm00580b. Biomater Sci. 2016. PMID: 27748775
Restoring PTEN activity in cancer cells through gene therapy has shown to inhibit cell growth and induce apoptosis, particularly in cells with a PTEN deficiency. Gene therapy, however, comes with some inherent risks such as triggering an immune response and permanen …
Restoring PTEN activity in cancer cells through gene therapy has shown to inhibit cell growth and induce apoptosis, particularly in cells wi …
Phosphatase and tensin homologue deficiency in glioblastoma confers resistance to radiation and temozolomide that is reversed by the protease inhibitor nelfinavir.
Jiang Z, Pore N, Cerniglia GJ, Mick R, Georgescu MM, Bernhard EJ, Hahn SM, Gupta AK, Maity A. Jiang Z, et al. Cancer Res. 2007 May 1;67(9):4467-73. doi: 10.1158/0008-5472.CAN-06-3398. Cancer Res. 2007. PMID: 17483362
Glioblastomas frequently have loss of the phosphatase and tensin homologue (PTEN), leading to the activation of the phosphoinositide-3-kinase (PI3K)/Akt pathway. We examined whether PTEN deficiency leads to radioresistance and whether this can be reversed by nelfina …
Glioblastomas frequently have loss of the phosphatase and tensin homologue (PTEN), leading to the activation of the phosphoinositide-3-kinas …
22 results