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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1960 1
1961 1
1965 39
1966 194
1967 217
1968 271
1969 289
1970 355
1971 378
1972 476
1973 569
1974 649
1975 930
1976 1241
1977 1248
1978 1468
1979 1786
1980 2071
1981 2282
1982 2550
1983 3050
1984 2861
1985 3534
1986 3893
1987 4447
1988 4534
1989 5647
1990 6762
1991 7170
1992 7591
1993 8261
1994 9490
1995 10382
1996 10188
1997 10360
1998 10770
1999 11529
2000 11164
2001 12015
2002 12257
2003 13477
2004 15192
2005 16338
2006 17345
2007 19074
2008 19578
2009 20612
2010 22501
2011 25328
2012 27442
2013 29771
2014 30081
2015 29783
2016 28761
2017 28461
2018 25337
2019 9462
2020 58
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498,826 results
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Page 1
Edoxaban for the Treatment of Cancer-Associated Venous Thromboembolism
Raskob GE, et al. N Engl J Med 2018 - Clinical Trial. PMID 29231094 Free article.
METHODS: In this open-label, noninferiority trial, we randomly assigned patients with cancer who had acute symptomatic or incidental venous thromboembolism to receive either low-molecular-weight heparin for at least 5 days followed by oral edoxaban at a dose of 60 mg once daily (edoxaban group) or subcutaneous dalteparin at a dose of 200 IU per kilogram of body weight once daily for 1 month followed by dalteparin at a dose of 150 IU per kilogram once daily (dalteparin group). ...
METHODS: In this open-label, noninferiority trial, we randomly assigned patients with cancer who had acute symptomatic or incidental venous thromboembolism to receive either low-molecular-weight heparin for at least 5 days followed by oral edoxaban at a dose of 60 mg once daily (edoxaban grou …
Randomized Controlled Trial of Humidified High-Flow Nasal Oxygen for Acute Respiratory Distress in the Emergency Department: The HOT-ER Study.
Jones PG, et al. Respir Care 2016 - Clinical Trial. PMID 26577199 Free article.
METHODS: This was a pragmatic open randomized controlled trial in adult subjects with hypoxia and tachypnea presenting to a tertiary academic hospital emergency department. ...Of these, 165 randomized to HFNC and 138 to standard O2 were analyzed. Baseline characteristics were similar. In the HFNC group, 3.6% (95% CI 1.5-7.9%) versus 7.2% (95% CI 3.8-13%) in the standard O2 group required mechanical ventilation in the emergency department (P = .16), and 5.5% (95% CI 2.8-10.2%) in HFNC versus 11.6% (95% CI 7.2-18.1%) in the standard O2 group required mechanical ventilation within 24 h of admission (P = .053). ...
METHODS: This was a pragmatic open randomized controlled trial in adult subjects with hypoxia and tachypnea presenting to a tertiary academic hospital emergency department. ...Of these, 165 randomized to HFNC and 138 to standard O2 were analyzed. Baseline characteristics …
Individually-tailored multifactorial intervention to reduce falls in the Malaysian Falls Assessment and Intervention Trial (MyFAIT): A randomized controlled trial.
Tan PJ, et al. PLoS One 2018 - Clinical Trial. PMID 30074996 Free PMC article.
DESIGN: Pragmatic, randomized-controlled trial. SETTING: Emergency room, medical outpatient and primary care clinic in a teaching hospital in Kuala Lumpur, Malaysia. ...TRIAL REGISTRATION: ISRCTN Registry no. ISRCTN11674947....
DESIGN: Pragmatic, randomized-controlled trial. SETTING: Emergency room, medical outpatient and primary care clinic in a teaching hospital in Kuala Lumpur, Malaysia. ...TRIAL REGISTRATION: ISRCTN Registry no. ISRCTN11674947....
Mindfulness-based cognitive therapy for patients with chronic, treatment-resistant depression: A pragmatic randomized controlled trial.
Cladder-Micus MB, et al. Depress Anxiety 2018 - Clinical Trial. PMID 30088834 Free PMC article.
METHOD: A pragmatic, multicenter, randomized-controlled trial was conducted comparing treatment-as-usual (TAU) with MBCT + TAU in 106 chronically depressed outpatients who previously received pharmacotherapy (≥4 weeks) and psychological treatment (≥10 sessions). ...
METHOD: A pragmatic, multicenter, randomized-controlled trial was conducted comparing treatment-as-usual (TAU) with MBCT + TAU in 106 chronically depressed outpatients who previously received pharmacotherapy (≥4 weeks) and psychological treatment (≥10 sessions). ...
Randomized clinical trial of observational versus antibiotic treatment for a first episode of CT-proven uncomplicated acute diverticulitis.
Daniels L, et al. Br J Surg 2017 - Clinical Trial. PMID 27686365
This trial compared the effectiveness of a strategy with or without antibiotics for a first episode of uncomplicated acute diverticulitis. ...
This trial compared the effectiveness of a strategy with or without antibiotics for a first episode of uncomplicated acute diverticulitis. ...
Treatment duration of febrile urinary tract infection: a pragmatic randomized, double-blind, placebo-controlled non-inferiority trial in men and women.
van Nieuwkoop C, et al. BMC Med 2017 - Clinical Trial. PMID 28366170 Free PMC article.
METHODS: A randomized placebo-controlled, double-blind, non-inferiority trial among 35 primary care centers and 7 emergency departments of regional hospitals in the Netherlands. ...TRIAL REGISTRATION: The study was registered at ClinicalTrials.gov [ NCT00809913 ; December 16, 2008] and trialregister.nl [ NTR1583 ; December 19, 2008]....
METHODS: A randomized placebo-controlled, double-blind, non-inferiority trial among 35 primary care centers and 7 emergency departments of regional hospitals in the Netherlands. ...TRIAL REGISTRATION: The study was registered at ClinicalTrials.gov [ NCT00809913 ; December …
Randomized controlled trial of the immediate and long-term effect of massage on adult postburn scar.
Nedelec B, et al. Burns 2019 - Clinical Trial. PMID 30626496
METHODS: We conducted a prospective, randomized, single-blinded, pragmatic, controlled, clinical trial evaluating the impact of a 12-week course of massage therapy. ...Two homogeneous, intra-individual scars were randomized to usual care control or massage therapy plus usual care. Massage, occupational or physical therapists provided massage treatment 3x/week for 12 weeks. ...
METHODS: We conducted a prospective, randomized, single-blinded, pragmatic, controlled, clinical trial evaluating the impact of a 12-week course of massage therapy. ...Two homogeneous, intra-individual scars were randomized to usual care control or massage therapy plus us …
Testing Test-Enhanced Continuing Medical Education: A Randomized Controlled Trial.
Feldman M, et al. Acad Med 2018 - Clinical Trial. PMID 30365427
METHOD: The authors conducted a randomized controlled trial comparing knowledge retention among learners who registered for an annual CPD conference at the University of Toronto in April 2016. Participants were randomized to receive an online preworkshop stand-alone MCQ test (no feedback) and a postworkshop MCQ test (with feedback) after a 14-day delay. ...
METHOD: The authors conducted a randomized controlled trial comparing knowledge retention among learners who registered for an annual CPD conference at the University of Toronto in April 2016. Participants were randomized to receive an online preworkshop stand-alone MCQ t …
Stress ulcer prophylaxis with a proton pump inhibitor versus placebo in critically ill patients (SUP-ICU trial): study protocol for a randomised controlled trial.
Krag M, et al. Trials 2016 - Clinical Trial. PMID 27093939 Free PMC article.
METHODS/DESIGN: The SUP-ICU trial is an investigator-initiated, pragmatic, international, multicentre, randomised, blinded, parallel-group trial of stress ulcer prophylaxis with a proton pump inhibitor versus placebo (saline) in 3350 acutely ill ICU patients at risk of gastrointestinal bleeding. ...TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT02467621 ....
METHODS/DESIGN: The SUP-ICU trial is an investigator-initiated, pragmatic, international, multicentre, randomised, blinded, parallel-group trial of stress ulcer prophylaxis with a proton pump inhibitor versus placebo (saline) in 3350 acutely ill ICU patients at risk of gastrointestinal …
The Heidelberg Milestones Communication Approach (MCA) for patients with prognosis <12 months: protocol for a mixed-methods study including a randomized controlled trial.
Siegle A, et al. Trials 2018 - Clinical Trial. PMID 30107809 Free PMC article.
Patient outcomes will be assessed in a pragmatic non-blinded randomized controlled trial and in qualitative interviews with patients and caregivers. ...TRIAL REGISTRATION: German Clinical Trials Register, DRKS00013649 and DRKS00013469. Registered on 22 December 2017....
Patient outcomes will be assessed in a pragmatic non-blinded randomized controlled trial and in qualitative interviews with patients and caregivers. ...TRIAL REGISTRATION: German Clinical Trials Register, DRKS00013649 and DRKS00013469. Registered on 22 December 2017....
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