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1980 14
1981 16
1982 11
1983 5
1984 8
1985 12
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1987 12
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1989 12
1990 17
1991 11
1992 8
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1994 10
1995 12
1996 15
1997 12
1998 12
1999 15
2000 21
2001 28
2002 20
2003 28
2004 28
2005 31
2006 26
2007 26
2008 31
2009 39
2010 44
2011 33
2012 56
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Biological age is increased by stress and restored upon recovery.
Poganik JR, Zhang B, Baht GS, Tyshkovskiy A, Deik A, Kerepesi C, Yim SH, Lu AT, Haghani A, Gong T, Hedman AM, Andolf E, Pershagen G, Almqvist C, Clish CB, Horvath S, White JP, Gladyshev VN. Poganik JR, et al. Cell Metab. 2023 May 2;35(5):807-820.e5. doi: 10.1016/j.cmet.2023.03.015. Epub 2023 Apr 21. Cell Metab. 2023. PMID: 37086720 Free PMC article.
However, recent in vitro studies have raised the possibility of age reversal. Here, we report that biological age is fluid and exhibits rapid changes in both directions. ...We also identify transient changes in biological age during major surgery, preg …
However, recent in vitro studies have raised the possibility of age reversal. Here, we report that biological age is fluid and …
Biological Age Predictors.
Jylhävä J, Pedersen NL, Hägg S. Jylhävä J, et al. EBioMedicine. 2017 Jul;21:29-36. doi: 10.1016/j.ebiom.2017.03.046. Epub 2017 Apr 1. EBioMedicine. 2017. PMID: 28396265 Free PMC article. Review.
The search for reliable indicators of biological age, rather than chronological age, has been ongoing for over three decades, and until recently, largely without success. Advances in the fields of molecular biology have increased the variety of potential candidate b …
The search for reliable indicators of biological age, rather than chronological age, has been ongoing for over three decades, …
Potential reversal of biological age in women following an 8-week methylation-supportive diet and lifestyle program: a case series.
Fitzgerald KN, Campbell T, Makarem S, Hodges R. Fitzgerald KN, et al. Aging (Albany NY). 2023 Mar 22;15(6):1833-1839. doi: 10.18632/aging.204602. Epub 2023 Mar 22. Aging (Albany NY). 2023. PMID: 36947707 Free PMC article.
Five of the six participants exhibited a biological age reduction of between 1.22 and 11.01 years from their baseline biological age. ...The average chronological age at the start of the program was 57.9 years and all but one participant had a biolo …
Five of the six participants exhibited a biological age reduction of between 1.22 and 11.01 years from their baseline biolo …
Progress in biological age research.
Li Z, Zhang W, Duan Y, Niu Y, Chen Y, Liu X, Dong Z, Zheng Y, Chen X, Feng Z, Wang Y, Zhao D, Sun X, Cai G, Jiang H, Chen X. Li Z, et al. Front Public Health. 2023 Apr 12;11:1074274. doi: 10.3389/fpubh.2023.1074274. eCollection 2023. Front Public Health. 2023. PMID: 37124811 Free PMC article. Review.
Biological age is influenced by the used biomarkers and standards in selected aging biomarkers and the statistical method to construct BA. ...This review summarizes the markers for each organ/system used to construct biological age and published litera …
Biological age is influenced by the used biomarkers and standards in selected aging biomarkers and the statistical method to c …
Biological Age Predictors: The Status Quo and Future Trends.
Erema VV, Yakovchik AY, Kashtanova DA, Bochkaeva ZV, Ivanov MV, Sosin DV, Matkava LR, Yudin VS, Makarov VV, Keskinov AA, Kraevoy SA, Yudin SM. Erema VV, et al. Int J Mol Sci. 2022 Dec 1;23(23):15103. doi: 10.3390/ijms232315103. Int J Mol Sci. 2022. PMID: 36499430 Free PMC article. Review.
Duly validated in a large cohort, models based on a combination of these markers could provide a highly accurate assessment of biological age and the pace of aging. Biological aging is a complex characteristic of chronological age (usually), health-to-age concordanc …
Duly validated in a large cohort, models based on a combination of these markers could provide a highly accurate assessment of biological …
Human age reversal: Fact or fiction?
Johnson AA, English BW, Shokhirev MN, Sinclair DA, Cuellar TL. Johnson AA, et al. Aging Cell. 2022 Aug;21(8):e13664. doi: 10.1111/acel.13664. Epub 2022 Jul 2. Aging Cell. 2022. PMID: 35778957 Free PMC article. Review.
Estimates of biological age are thought to be provided by aging clocks, which are computational models (e.g., elastic net) that use a set of inputs (e.g., DNA methylation sites) to make a prediction. ...Specific molecules have been associated with the reduction or r …
Estimates of biological age are thought to be provided by aging clocks, which are computational models (e.g., elastic net) tha …
Biological age and environmental risk factors for dementia and stroke: Molecular mechanisms.
Knobel P, Litke R, Mobbs CV. Knobel P, et al. Front Aging Neurosci. 2022 Dec 22;14:1042488. doi: 10.3389/fnagi.2022.1042488. eCollection 2022. Front Aging Neurosci. 2022. PMID: 36620763 Free PMC article. Review.
Conversely, both age and environmental risk factors are associated with the accumulation of somatic mutations in mitotic cells and epigenetic modifications that are a measure of "biological age", a better predictor of age-related morbidity and mortality than chronol …
Conversely, both age and environmental risk factors are associated with the accumulation of somatic mutations in mitotic cells and epigeneti …
Measuring biological age.
Kriebs A. Kriebs A. Nat Aging. 2022 Jun;2(6):457-459. doi: 10.1038/s43587-022-00234-8. Nat Aging. 2022. PMID: 37118447 No abstract available.
Determination of Biological Age: Geriatric Assessment vs Biological Biomarkers.
Diebel LWM, Rockwood K. Diebel LWM, et al. Curr Oncol Rep. 2021 Jul 16;23(9):104. doi: 10.1007/s11912-021-01097-9. Curr Oncol Rep. 2021. PMID: 34269912 Free PMC article. Review.
PURPOSE OF REVIEW: Biological age is the concept of using biophysiological measures to more accurately determine an individual's age-related risk of adverse outcomes. Grading of the degree of frailty and measuring biomarkers are distinct methods of measuring biol …
PURPOSE OF REVIEW: Biological age is the concept of using biophysiological measures to more accurately determine an individual …
Deep learning for biological age estimation.
Ashiqur Rahman S, Giacobbi P, Pyles L, Mullett C, Doretto G, Adjeroh DA. Ashiqur Rahman S, et al. Brief Bioinform. 2021 Mar 22;22(2):1767-1781. doi: 10.1093/bib/bbaa021. Brief Bioinform. 2021. PMID: 32363395 Free PMC article. Review.
In this article, we review the recent literature on applying deep learning in biological age estimation. We consider the current data modalities that have been used to study aging and the deep learning architectures that have been applied. We identify four broad cla …
In this article, we review the recent literature on applying deep learning in biological age estimation. We consider the curre …
Biological Versus Chronological Aging: JACC Focus Seminar.
Hamczyk MR, Nevado RM, Barettino A, Fuster V, Andrés V. Hamczyk MR, et al. J Am Coll Cardiol. 2020 Mar 3;75(8):919-930. doi: 10.1016/j.jacc.2019.11.062. J Am Coll Cardiol. 2020. PMID: 32130928 Free article. Review.
However, strategies to extend health span and life span require understanding of interindividual differences in age-dependent functional decline, known as biological aging. This review summarizes the current knowledge on biological age biomarkers, factors influencin …
However, strategies to extend health span and life span require understanding of interindividual differences in age-dependent functional dec …
A toolkit for quantification of biological age from blood chemistry and organ function test data: BioAge.
Kwon D, Belsky DW. Kwon D, et al. Geroscience. 2021 Dec;43(6):2795-2808. doi: 10.1007/s11357-021-00480-5. Epub 2021 Nov 2. Geroscience. 2021. PMID: 34725754 Free PMC article.
Publicly available software packages to compute biological aging measurements from DNA methylation data have accelerated dissemination of these measures and generated rapid gains in knowledge about how different measures perform in a range of datasets. Biological age …
Publicly available software packages to compute biological aging measurements from DNA methylation data have accelerated dissemination of th …
Sarcopenia, biological age and treatment eligibility in patients with cancer.
Laviano A. Laviano A. Curr Opin Clin Nutr Metab Care. 2023 Jan 1;26(1):59-63. doi: 10.1097/MCO.0000000000000888. Epub 2022 Dec 6. Curr Opin Clin Nutr Metab Care. 2023. PMID: 36542536 Review.
RECENT FINDINGS: The role of chronological age in identifying patients with increased likelihood to respond to therapies has been challenged, pointing to biological age (i.e. accumulated damage to biological systems over the life course, leading to loss of reserve a …
RECENT FINDINGS: The role of chronological age in identifying patients with increased likelihood to respond to therapies has been challenged …
Modeling the rate of senescence: can estimated biological age predict mortality more accurately than chronological age?
Levine ME. Levine ME. J Gerontol A Biol Sci Med Sci. 2013 Jun;68(6):667-74. doi: 10.1093/gerona/gls233. Epub 2012 Dec 3. J Gerontol A Biol Sci Med Sci. 2013. PMID: 23213031 Free PMC article.
Biological age (BA) is useful for examining differences in aging rates. ...
Biological age (BA) is useful for examining differences in aging rates. ...
Measuring biological age using metabolomics.
Robinson O, Lau CE. Robinson O, et al. Aging (Albany NY). 2020 Nov 29;12(22):22352-22353. doi: 10.18632/aging.104216. Epub 2020 Nov 29. Aging (Albany NY). 2020. PMID: 33253122 Free PMC article. No abstract available.
Biological age estimation using circulating blood biomarkers.
Bortz J, Guariglia A, Klaric L, Tang D, Ward P, Geer M, Chadeau-Hyam M, Vuckovic D, Joshi PK. Bortz J, et al. Commun Biol. 2023 Oct 26;6(1):1089. doi: 10.1038/s42003-023-05456-z. Commun Biol. 2023. PMID: 37884697 Free PMC article.
Biological age captures physiological deterioration better than chronological age and is amenable to interventions. Blood-based biomarkers have been identified as suitable candidates for biological age estimation. This study aims to improve biologic …
Biological age captures physiological deterioration better than chronological age and is amenable to interventions. Blood-base …
Biological Age Acceleration and Motoric Cognitive Risk Syndrome.
Sathyan S, Ayers E, Adhikari D, Gao T, Milman S, Barzilai N, Verghese J. Sathyan S, et al. Ann Neurol. 2023 Jun;93(6):1187-1197. doi: 10.1002/ana.26624. Epub 2023 Mar 13. Ann Neurol. 2023. PMID: 36843279 Free PMC article.
OBJECTIVE: Motoric cognitive risk (MCR) syndrome, a predementia syndrome characterized by slow gait and subjective cognitive concerns, is associated with multiple age-related risk factors. We hypothesized that MCR is associated with biological age acceleration. We e …
OBJECTIVE: Motoric cognitive risk (MCR) syndrome, a predementia syndrome characterized by slow gait and subjective cognitive concerns, is as …
Predictors of Biological Age: The Implications for Wellness and Aging Research.
Lohman T, Bains G, Berk L, Lohman E. Lohman T, et al. Gerontol Geriatr Med. 2021 Sep 26;7:23337214211046419. doi: 10.1177/23337214211046419. eCollection 2021 Jan-Dec. Gerontol Geriatr Med. 2021. PMID: 34595331 Free PMC article. Review.
As healthspan and lifespan research breakthroughs have become more commonplace, the need for valid, practical markers of biological age is becoming increasingly paramount. The accessibility and affordability of biological age predictors that can reveal …
As healthspan and lifespan research breakthroughs have become more commonplace, the need for valid, practical markers of biological …
Biological age of transplanted livers.
Capri M, Franceschi C, Cescon M. Capri M, et al. Aging (Albany NY). 2018 Feb 1;10(2):156-157. doi: 10.18632/aging.101378. Aging (Albany NY). 2018. PMID: 29394495 Free PMC article. No abstract available.
Conceptual Overview of Biological Age Estimation.
Salih A, Nichols T, Szabo L, Petersen SE, Raisi-Estabragh Z. Salih A, et al. Aging Dis. 2023 Jun 1;14(3):583-588. doi: 10.14336/AD.2022.1107. Aging Dis. 2023. PMID: 37191413 Free PMC article.
Chronological age is an imperfect measure of the aging process, which is affected by a wide range of genetic and environmental exposures. Biological age estimates may be derived using mathematical modelling with biomarkers set as predictors and chronological age as …
Chronological age is an imperfect measure of the aging process, which is affected by a wide range of genetic and environmental exposures. …
Dietary flavonoids intake contributes to delay biological aging process: analysis from NHANES dataset.
Xing W, Gao W, Zhao Z, Xu X, Bu H, Su H, Mao G, Chen J. Xing W, et al. J Transl Med. 2023 Jul 21;21(1):492. doi: 10.1186/s12967-023-04321-1. J Transl Med. 2023. PMID: 37480074 Free PMC article.
BACKGROUND: Diet may influence biological aging and the discrepancy (age) between a subject's biological age (BA) and chronological age (CA). We aimed to investigate the correlation of dietary flavonoids with the age of organs (heart, kidney, liver) and the whole bo …
BACKGROUND: Diet may influence biological aging and the discrepancy (age) between a subject's biological age (BA) and chronolo …
Association between life's essential 8 and biological ageing among US adults.
Zhang R, Wu M, Zhang W, Liu X, Pu J, Wei T, Zhu Z, Tang Z, Wei N, Liu B, Cui Q, Wang J, Liu F, Lv Y. Zhang R, et al. J Transl Med. 2023 Sep 14;21(1):622. doi: 10.1186/s12967-023-04495-8. J Transl Med. 2023. PMID: 37710295 Free PMC article.
Biological ageing was assessed by different methods including phenotypic age, phenotypic age acceleration (PhenoAgeAccel), biological age and biological age acceleration (BioAgeAccel). Correlations were analyzed by weighted linear regression and restri …
Biological ageing was assessed by different methods including phenotypic age, phenotypic age acceleration (PhenoAgeAccel), biological …
VOCs profile can discriminate biological age.
Conte M, Conte G, Salvioli S. Conte M, et al. Aging (Albany NY). 2021 Apr 11;13(7):9156-9157. doi: 10.18632/aging.202959. Epub 2021 Apr 11. Aging (Albany NY). 2021. PMID: 33846279 Free PMC article. No abstract available.
Multi-omics approaches to human biological age estimation.
Solovev I, Shaposhnikov M, Moskalev A. Solovev I, et al. Mech Ageing Dev. 2020 Jan;185:111192. doi: 10.1016/j.mad.2019.111192. Epub 2019 Nov 28. Mech Ageing Dev. 2020. PMID: 31786174 Review.
We found patents, up-to-date multi-omics datasets and studies, which include bioinformatics innovations to predict biological age in humans. We hope that the review will be also useful for clinicians, because it follows majorly translational purposes....
We found patents, up-to-date multi-omics datasets and studies, which include bioinformatics innovations to predict biological age …
An interpretable biological age.
Zhang Q. Zhang Q. Lancet Healthy Longev. 2023 Dec;4(12):e662-e663. doi: 10.1016/S2666-7568(23)00213-1. Epub 2023 Nov 6. Lancet Healthy Longev. 2023. PMID: 37944548 Free article. No abstract available.
Examination of the Dimensions of Biological Age.
Jazwinski SM, Kim S. Jazwinski SM, et al. Front Genet. 2019 Mar 26;10:263. doi: 10.3389/fgene.2019.00263. eCollection 2019. Front Genet. 2019. PMID: 30972107 Free PMC article. Review.
The gut microbiome loses complexity in tandem with the host, as biological age increases, with likely impact on host metabolism and immunity. Specific DNA methylation changes are associated with biological age. They suggest declining connectivity withi …
The gut microbiome loses complexity in tandem with the host, as biological age increases, with likely impact on host metabolis …
Methylation-Based Biological Age and Hypertension Prevalence and Incidence.
Kresovich JK, Sandler DP, Taylor JA. Kresovich JK, et al. Hypertension. 2023 Jun;80(6):1213-1222. doi: 10.1161/HYPERTENSIONAHA.122.20796. Epub 2023 Mar 28. Hypertension. 2023. PMID: 36974720 Free article.
Blood DNA methylation profiles have been used to derive metrics of biological age that capture age-related physiological change, disease risk, and mortality. The relationships between hypertension and DNA methylation-based biological age metrics have y …
Blood DNA methylation profiles have been used to derive metrics of biological age that capture age-related physiological chang …
COVID-19 mortality as a fingerprint of biological age.
Polidori MC, Sies H, Ferrucci L, Benzing T. Polidori MC, et al. Ageing Res Rev. 2021 May;67:101308. doi: 10.1016/j.arr.2021.101308. Epub 2021 Feb 20. Ageing Res Rev. 2021. PMID: 33621704 Free PMC article. Review.
A closer analysis of the existing data supports a possible role of biological age rather than chronological age in the prognosis of COVID-19. ...
A closer analysis of the existing data supports a possible role of biological age rather than chronological age in the prognos …
Assessing biological age: practicality?
Bulpitt CJ. Bulpitt CJ. Gerontology. 1995;41(6):315-21. doi: 10.1159/000213701. Gerontology. 1995. PMID: 8586286 Review.
There are many problems in measuring "biological" age rather than chronological age, not least the necessity of demonstrating that this measure has validity in terms of better predicting mortality or morbidity. This review considers nine problems in measuring bio …
There are many problems in measuring "biological" age rather than chronological age, not least the necessity of demonstrating …
Assessing Biological Age: The Potential of ECG Evaluation Using Artificial Intelligence: JACC Family Series.
Lopez-Jimenez F, Kapa S, Friedman PA, LeBrasseur NK, Klavetter E, Mangold KE, Attia ZI. Lopez-Jimenez F, et al. JACC Clin Electrophysiol. 2024 Apr;10(4):775-789. doi: 10.1016/j.jacep.2024.02.011. Epub 2024 Apr 8. JACC Clin Electrophysiol. 2024. PMID: 38597855 Review.
Biological age may be a more valuable predictor of morbidity and mortality than a person's chronological age. Mathematical models have been used for decades to predict biological age, but recent developments in artificial intelligence (AI) have led to …
Biological age may be a more valuable predictor of morbidity and mortality than a person's chronological age. Mathematical mod …
Development of a model for the prediction of biological age.
Ni X, Zhao H, Li R, Su H, Jiao J, Yang Z, Lv Y, Pang G, Sun M, Hu C, Yuan H. Ni X, et al. Comput Methods Programs Biomed. 2023 Oct;240:107686. doi: 10.1016/j.cmpb.2023.107686. Epub 2023 Jun 24. Comput Methods Programs Biomed. 2023. PMID: 37421874 Free article.
BACKGROUND AND OBJECTIVE: Rates of aging vary markedly among individuals, and biological age serves as a more reliable predictor of current health status than does chronological age. As such, the ability to predict biological age can support appropriat …
BACKGROUND AND OBJECTIVE: Rates of aging vary markedly among individuals, and biological age serves as a more reliable predict …
Biological age and brain age in midlife: relationship to multimorbidity and mental health.
Zhang F, Chang H, Schaefer SM, Gou J. Zhang F, et al. Neurobiol Aging. 2023 Dec;132:145-153. doi: 10.1016/j.neurobiolaging.2023.09.003. Epub 2023 Sep 11. Neurobiol Aging. 2023. PMID: 37804610 Free PMC article.
Biological age and brain age estimated using biological and neuroimaging measures have recently emerged as surrogate aging biomarkers shown to be predictive of diverse health outcomes. ...Ensemble learning is utilized to combine multiple machine learning models to e …
Biological age and brain age estimated using biological and neuroimaging measures have recently emerged as surrogate aging bio …
Biological age as a predictor of unplanned intensive care readmission during the same hospitalization.
Ho KM. Ho KM. Heart Lung. 2023 Nov-Dec;62:249-255. doi: 10.1016/j.hrtlng.2023.08.010. Epub 2023 Aug 21. Heart Lung. 2023. PMID: 37611385 Free article.
BACKGROUND: Biological age is increasingly being recognized as an important predictor of health but its utility in acute care setting remains uncertain. OBJECTIVE: We assessed whether biological age on intensive care unit (ICU) admission can predict un …
BACKGROUND: Biological age is increasingly being recognized as an important predictor of health but its utility in acute care …
Biological age in healthy elderly predicts aging-related diseases including dementia.
Wu JW, Yaqub A, Ma Y, Koudstaal W, Hofman A, Ikram MA, Ghanbari M, Goudsmit J. Wu JW, et al. Sci Rep. 2021 Aug 5;11(1):15929. doi: 10.1038/s41598-021-95425-5. Sci Rep. 2021. PMID: 34354164 Free PMC article.
Application of biological age as a measure of an individuals health status offers new perspectives into extension of both lifespan and healthspan. ...We conclude that accelerated biological age for a given age is a predictor of major age-related morbid …
Application of biological age as a measure of an individuals health status offers new perspectives into extension of both life …
Application of AI in biological age prediction.
Meng D, Zhang S, Huang Y, Mao K, Han JJ. Meng D, et al. Curr Opin Struct Biol. 2024 Apr;85:102777. doi: 10.1016/j.sbi.2024.102777. Epub 2024 Feb 3. Curr Opin Struct Biol. 2024. PMID: 38310737 Review.
The development of anti-aging interventions requires quantitative measurement of biological age. Machine learning models, known as "aging clocks," are built by leveraging diverse aging biomarkers that vary across lifespan to predict biological age. In …
The development of anti-aging interventions requires quantitative measurement of biological age. Machine learning models, know …
Assessing biological age: reality?
Bellamy D. Bellamy D. Gerontology. 1995;41(6):322-4. doi: 10.1159/000213702. Gerontology. 1995. PMID: 8586287 Review.
The conclusion is that clinical measurements have little value in defining biological age and lifespan. These latter are the outcomes of uncorrected molecular errors which are far removed in time and place from their clinical expressions....
The conclusion is that clinical measurements have little value in defining biological age and lifespan. These latter are the o …
Biomarkers selection and mathematical modeling in biological age estimation.
Bafei SEC, Shen C. Bafei SEC, et al. NPJ Aging. 2023 Jul 1;9(1):13. doi: 10.1038/s41514-023-00110-8. NPJ Aging. 2023. PMID: 37393295 Free PMC article. Review.
Biological age (BA) is important for clinical monitoring and preventing aging-related disorders and disabilities. ...
Biological age (BA) is important for clinical monitoring and preventing aging-related disorders and disabilities. ...
Biological age in diabetes and precision medicine.
Cortez BN, Bahour N, Aguayo-Mazzucato C. Cortez BN, et al. Aging (Albany NY). 2022 Jun 6;14(11):4622-4623. doi: 10.18632/aging.204123. Epub 2022 Jun 6. Aging (Albany NY). 2022. PMID: 35666709 Free PMC article. No abstract available.
Biological age for chronic kidney disease patients using index model.
Abu Bakar SA, Syed Mohamed Shahruddin SNS, Ismail N, Wan Md Adnan WAH. Abu Bakar SA, et al. PeerJ. 2022 Aug 1;10:e13694. doi: 10.7717/peerj.13694. eCollection 2022. PeerJ. 2022. PMID: 35935256 Free PMC article.
The estimation of biological age (BA) is an important asymptomatic measure that can be used to understand the physical changes and the aging process of a living being. Factors that contribute towards profiling the human biological age can be diverse. T …
The estimation of biological age (BA) is an important asymptomatic measure that can be used to understand the physical changes …
Old plasma dilution reduces human biological age: a clinical study.
Kim D, Kiprov DD, Luellen C, Lieb M, Liu C, Watanabe E, Mei X, Cassaleto K, Kramer J, Conboy MJ, Conboy IM. Kim D, et al. Geroscience. 2022 Dec;44(6):2701-2720. doi: 10.1007/s11357-022-00645-w. Epub 2022 Aug 24. Geroscience. 2022. PMID: 35999337 Free PMC article.
This work extrapolates to humans the previous animal studies on blood heterochronicity and establishes a novel direct measurement of biological age. Our results support the hypothesis that, similar to mice, human aging is driven by age-imposed systemic molecular exc …
This work extrapolates to humans the previous animal studies on blood heterochronicity and establishes a novel direct measurement of biol …
Associations of four biological age markers with child development: A multi-omic analysis in the European HELIX cohort.
Robinson O, Lau CE, Joo S, Andrusaityte S, Borras E, de Prado-Bert P, Chatzi L, Keun HC, Grazuleviciene R, Gutzkow KB, Maitre L, Martens DS, Sabido E, Siroux V, Urquiza J, Vafeiadi M, Wright J, Nawrot TS, Bustamante M, Vrijheid M. Robinson O, et al. Elife. 2023 Jun 6;12:e85104. doi: 10.7554/eLife.85104. Elife. 2023. PMID: 37278618 Free PMC article.
BACKGROUND: While biological age in adults is often understood as representing general health and resilience, the conceptual interpretation of accelerated biological age in children and its relationship to development remains unclear. ...Despite this, …
BACKGROUND: While biological age in adults is often understood as representing general health and resilience, the conceptual i …
Applying a Life Course Biological Age Framework to Improving the Care of Individuals With Adult Cancers: Review and Research Recommendations.
Mandelblatt JS, Ahles TA, Lippman ME, Isaacs C, Adams-Campbell L, Saykin AJ, Cohen HJ, Carroll J. Mandelblatt JS, et al. JAMA Oncol. 2021 Nov 1;7(11):1692-1699. doi: 10.1001/jamaoncol.2021.1160. JAMA Oncol. 2021. PMID: 34351358 Free PMC article. Review.
Managing cancer in these individuals is complex, based on differences in biological age at diagnosis. Biological age is a measure of accumulated life course damage to biological systems, loss of reserve, and vulnerability to functional deterioration an …
Managing cancer in these individuals is complex, based on differences in biological age at diagnosis. Biological age …
Modelling biological age based on plasma peptides in Han Chinese adults.
Cao W, Zheng D, Wang G, Zhang J, Ge S, Singh M, Wang H, Song M, Li D, Wang W, Xu X, Wang Y. Cao W, et al. Aging (Albany NY). 2020 Jun 5;12(11):10676-10686. doi: 10.18632/aging.103286. Epub 2020 Jun 5. Aging (Albany NY). 2020. PMID: 32501290 Free PMC article.
Furthermore, the linear correlation between the actual age and biological age was 0.851 (95% confidence interval: 0.836-0.864) and 0.842 (95% confidence interval: 0.810-0.869) in the training and validation sets, respectively. The biological age based …
Furthermore, the linear correlation between the actual age and biological age was 0.851 (95% confidence interval: 0.836-0.864) …
A Targeted Epigenetic Clock for the Prediction of Biological Age.
Gensous N, Sala C, Pirazzini C, Ravaioli F, Milazzo M, Kwiatkowska KM, Marasco E, De Fanti S, Giuliani C, Pellegrini C, Santoro A, Capri M, Salvioli S, Monti D, Castellani G, Franceschi C, Bacalini MG, Garagnani P. Gensous N, et al. Cells. 2022 Dec 14;11(24):4044. doi: 10.3390/cells11244044. Cells. 2022. PMID: 36552808 Free PMC article.
Epigenetic clocks were initially developed to track chronological age, but accumulating evidence indicates that they can also predict biological age. They are usually based on the analysis of DNA methylation by genome-wide methods, but targeted approaches, based on …
Epigenetic clocks were initially developed to track chronological age, but accumulating evidence indicates that they can also predict bio …
The NHANES Biological Age Index demonstrates accelerated aging in MS patients.
Miner AE, Yang JH, Kinkel RP, Graves JS. Miner AE, et al. Mult Scler Relat Disord. 2023 Sep;77:104859. doi: 10.1016/j.msard.2023.104859. Epub 2023 Jul 7. Mult Scler Relat Disord. 2023. PMID: 37473592 Free article.
Both normal aging and accelerated aging from MS may negatively impact disease course. Multi-marker indices of aging, such as the NHANES biological age index (BAI), may be more robust than single biomarkers in capturing biological age and are strongly a …
Both normal aging and accelerated aging from MS may negatively impact disease course. Multi-marker indices of aging, such as the NHANES b …
Frailty Index as a clinical measure of biological age in psychiatry.
Bersani FS, Canevelli M, Cesari M, Maggioni E, Pasquini M, Wolkowitz OM, Ferracuti S, Biondi M, Bruno G. Bersani FS, et al. J Affect Disord. 2020 May 1;268:183-187. doi: 10.1016/j.jad.2020.03.015. Epub 2020 Mar 6. J Affect Disord. 2020. PMID: 32174476 Review.
METHODS: In the present manuscript we propose that measuring frailty, a general product of organismal ageing, through the "Frailty Index" (FI), a recently-emerged macroscopic indicator of functional status and biological age, adds an important marker to the measurem …
METHODS: In the present manuscript we propose that measuring frailty, a general product of organismal ageing, through the "Frailty Index" (F …
Should we invest in biological age predictors to treat colorectal cancer in older adults?
Hägg S, Jylhävä J. Hägg S, et al. Eur J Surg Oncol. 2020 Mar;46(3):316-320. doi: 10.1016/j.ejso.2019.11.003. Epub 2019 Nov 8. Eur J Surg Oncol. 2020. PMID: 31761509 Free article. Review.
Other types of biomarkers of aging are useful to calculate biological age, such as metabolites, protein levels, inflammatory markers and clinical biomarkers, where composite scores of biomarkers have been used to assess the risk of CRC and colorectal adenomas. ...In …
Other types of biomarkers of aging are useful to calculate biological age, such as metabolites, protein levels, inflammatory m …
ExplaiNAble BioLogical Age (ENABL Age): an artificial intelligence framework for interpretable biological age.
Qiu W, Chen H, Kaeberlein M, Lee SI. Qiu W, et al. Lancet Healthy Longev. 2023 Dec;4(12):e711-e723. doi: 10.1016/S2666-7568(23)00189-7. Epub 2023 Nov 6. Lancet Healthy Longev. 2023. PMID: 37944549 Free article.
BACKGROUND: Biological age is a measure of health that offers insights into ageing. The existing age clocks, although valuable, often trade off accuracy and interpretability. We introduce ExplaiNAble BioLogical Age (ENABL Age), a computational framewor …
BACKGROUND: Biological age is a measure of health that offers insights into ageing. The existing age clocks, although valuable …
Aging clocks & mortality timers, methylation, glycomic, telomeric and more. A window to measuring biological age.
Palmer RD. Palmer RD. Aging Med (Milton). 2022 Feb 5;5(2):120-125. doi: 10.1002/agm2.12197. eCollection 2022 Jun. Aging Med (Milton). 2022. PMID: 35783114 Free PMC article. Review.
Research has led to aging clocks being developed that claim to predict biological age as opposed to chronological age. Aging could be regarded as a measured loss of homeostatic biological equilibrium that augments biological decay in fully developed tissues. Measuri …
Research has led to aging clocks being developed that claim to predict biological age as opposed to chronological age. Aging c …
Epigenetic age prediction.
Simpson DJ, Chandra T. Simpson DJ, et al. Aging Cell. 2021 Sep;20(9):e13452. doi: 10.1111/acel.13452. Epub 2021 Aug 20. Aging Cell. 2021. PMID: 34415665 Free PMC article. Review.
Progress in molecular ageing research was slow because the tools predicting whether someone aged slowly or fast (biological age) were unreliable. To understand ageing as a risk factor for disease and to develop interventions, the molecular ageing field needed a quan …
Progress in molecular ageing research was slow because the tools predicting whether someone aged slowly or fast (biological age …
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