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Methylenetetrahydrofolate (MTHFR), the One-Carbon Cycle, and Cardiovascular Risks.
Raghubeer S, Matsha TE. Raghubeer S, et al. Nutrients. 2021 Dec 20;13(12):4562. doi: 10.3390/nu13124562. Nutrients. 2021. PMID: 34960114 Free PMC article. Review.
The 5-10-methylenetetrahydrofolate reductase (MTHFR) enzyme is vital for cellular homeostasis due to its key functions in the one-carbon cycle, which include methionine and folate metabolism and protein, DNA, and RNA synthesis. ...
The 5-10-methylenetetrahydrofolate reductase (MTHFR) enzyme is vital for cellular homeostasis due to its key fun …
Shifting landscapes of human MTHFR missense-variant effects.
Weile J, Kishore N, Sun S, Maaieh R, Verby M, Li R, Fotiadou I, Kitaygorodsky J, Wu Y, Holenstein A, Bürer C, Blomgren L, Yang S, Nussbaum R, Rozen R, Watkins D, Gebbia M, Kozich V, Garton M, Froese DS, Roth FP. Weile J, et al. Am J Hum Genet. 2021 Jul 1;108(7):1283-1300. doi: 10.1016/j.ajhg.2021.05.009. Am J Hum Genet. 2021. PMID: 34214447 Free PMC article.
Most rare clinical missense variants cannot currently be classified as pathogenic or benign. Deficiency in human 5,10-methylenetetrahydrofolate reductase (MTHFR), the most common inherited disorder of folate metabolism, is caused primarily by rare miss …
Most rare clinical missense variants cannot currently be classified as pathogenic or benign. Deficiency in human 5,10-methy …
The methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism is associated with breast cancer subtype susceptibility in southwestern China.
Li Z, Zhang J, Zou W, Xu Q, Li S, Wu J, Zhu L, Zhang Y, Xu L, Zhang Y, Luo Q, Nie J, Li X, Zou T, Chen C. Li Z, et al. PLoS One. 2021 Jul 9;16(7):e0254267. doi: 10.1371/journal.pone.0254267. eCollection 2021. PLoS One. 2021. PMID: 34242313 Free PMC article.
Methylenetetrahydrofolate reductase (MTHFR), a folate-dependent enzyme, is reportedly involved in several cancer types. ...
Methylenetetrahydrofolate reductase (MTHFR), a folate-dependent enzyme, is reportedly involved in several cancer types. ...
Association between MTHFR (677C>T and 1298A>C) polymorphisms and psychiatric disorder: A meta-analysis.
Meng X, Zheng JL, Sun ML, Lai HY, Wang BJ, Yao J, Wang H. Meng X, et al. PLoS One. 2022 Jul 14;17(7):e0271170. doi: 10.1371/journal.pone.0271170. eCollection 2022. PLoS One. 2022. PMID: 35834596 Free PMC article.
Recent studies showed that genetic polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHFR) is related to attention-deficit hyperactivity disorder (ADHD), bipolar disorder (BD) and schizophrenia (SCZ). ...
Recent studies showed that genetic polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHFR) is related t …
MTHFR and risk of stroke and heart disease in a low-folate population: a prospective study of 156 000 Chinese adults.
Bennett DA, Parish S, Millwood IY, Guo Y, Chen Y, Turnbull I, Yang L, Lv J, Yu C, Davey Smith G, Wang Y, Wang Y, Peto R, Collins R, Walters RG, Li L, Chen Z, Clarke R; China Kadoorie Biobank (CKB) Study Collaborative Group. Bennett DA, et al. Int J Epidemiol. 2023 Dec 25;52(6):1862-1869. doi: 10.1093/ije/dyad147. Int J Epidemiol. 2023. PMID: 37898918 Free PMC article.
BACKGROUND: The relevance of folic acid for stroke prevention in low-folate populations such as in China is uncertain. Genetic studies of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism, which increases plasma homocysteine (tHcy) levels, could cla …
BACKGROUND: The relevance of folic acid for stroke prevention in low-folate populations such as in China is uncertain. Genetic studies of th …
Association of MTHFR gene C677T polymorphism with pregnancy outcome.
Huang LL, Tong JR, Huang Y, Wei YN, Chen HF, Chen Y, Su JY, Deng L. Huang LL, et al. Eur Rev Med Pharmacol Sci. 2023 Jan;27(1):166-171. doi: 10.26355/eurrev_202301_30868. Eur Rev Med Pharmacol Sci. 2023. PMID: 36647865 Free article.
OBJECTIVE: The two objectives of the present study were to analyze the correlation between pregnancy outcomes and methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism, and to provide evidence for clinical improvement of adverse pregnancy outcomes. ...
OBJECTIVE: The two objectives of the present study were to analyze the correlation between pregnancy outcomes and methylenetetrahydrofola …
165 results