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New Directions in Treatment of Hypoparathyroidism.
Tabacco G, Bilezikian JP. Tabacco G, et al. Endocrinol Metab Clin North Am. 2018 Dec;47(4):901-915. doi: 10.1016/j.ecl.2018.07.013. Endocrinol Metab Clin North Am. 2018. PMID: 30390821 Review.
The history of parathyroid hormone (PTH) replacement therapy for hypoparathyroidism begins in 1929. In 2015, the Food and Drug Administration approved recombinant human PTH(1-84) [rhPTH(1-84)] as a treatment for hypoparathyroidism. ...Calcilytic compounds hav …
The history of parathyroid hormone (PTH) replacement therapy for hypoparathyroidism begins in 1929. In 2015, the Food and Drug Admini …
Advances in the treatment of hypoparathyroidism with PTH 1-34.
Winer KK. Winer KK. Bone. 2019 Mar;120:535-541. doi: 10.1016/j.bone.2018.09.018. Epub 2018 Sep 21. Bone. 2019. PMID: 30243992 Review.
Twenty-five years ago, we launched the first systematic investigation into synthetic human PTH 1-34 replacement therapy in both adults and children. These studies led to our current understanding of the complex nature of PTH 1-34 therapy and to the cha …
Twenty-five years ago, we launched the first systematic investigation into synthetic human PTH 1-34 replacement therapy in bot …
Treatment of Hypoparathyroidism by Re-Establishing the Effects of Parathyroid Hormone.
Rejnmark L. Rejnmark L. Endocrinol Metab (Seoul). 2024 Apr;39(2):262-266. doi: 10.3803/EnM.2024.1916. Epub 2024 Apr 4. Endocrinol Metab (Seoul). 2024. PMID: 38572533 Free PMC article. Review.
Despite normalization of calcium levels, the conventional treatment is associated with fluctuations in calcium levels, hypercalciuria, renal impairment, and decreased quality of life (QoL). Replacement therapy with parathyroid hormone (PTH)(1-84) is an option in som …
Despite normalization of calcium levels, the conventional treatment is associated with fluctuations in calcium levels, hypercalciuria, renal …
Efficacy and Toxicity of Calcitonin Treatment in Children with Cherubism: A Single-Center Cohort Study.
Schreuder WH, Meijer EB, Cleven AHG, Edelenbos E, Klop C, Schreurs R, de Jong RT, van Maarle MC, Horsthuis RBG, de Lange J, van den Berg H. Schreuder WH, et al. J Bone Miner Res. 2023 Dec;38(12):1822-1833. doi: 10.1002/jbmr.4922. Epub 2023 Nov 3. J Bone Miner Res. 2023. PMID: 37823782 Free article.
Cherubism is a rare autosomal dominant disease characterized by expansile osteolytic jawbone lesions. ...Most adverse effects were mild and low grade, with the most severe being one grade 3 symptomatic hypocalcemia requiring hospitalization and early treatmen …
Cherubism is a rare autosomal dominant disease characterized by expansile osteolytic jawbone lesions. ...Most adverse effects …
GENETICS IN ENDOCRINOLOGY: Gain and loss of function mutations of the calcium-sensing receptor and associated proteins: current treatment concepts.
Mayr B, Schnabel D, Dörr HG, Schöfl C. Mayr B, et al. Eur J Endocrinol. 2016 May;174(5):R189-208. doi: 10.1530/EJE-15-1028. Epub 2015 Dec 8. Eur J Endocrinol. 2016. PMID: 26646938 Review.
Therapeutic concepts for these rare diseases range from general therapies of hyper- and hypo-calcemic conditions to more pathophysiology oriented approaches such as parathyroid hormone (PTH) substitution and allosteric CASR modulators. ...We conducted a literature s …
Therapeutic concepts for these rare diseases range from general therapies of hyper- and hypo-calcemic conditions to more patho …
Genetic Screening in a Large Chinese Cohort of Childhood Onset Hypoparathyroidism by Next-Generation Sequencing Combined with TBX1-MLPA.
Wang Y, Nie M, Wang O, Li Y, Jiang Y, Li M, Xia W, Xing X. Wang Y, et al. J Bone Miner Res. 2019 Dec;34(12):2254-2263. doi: 10.1002/jbmr.3854. Epub 2019 Nov 13. J Bone Miner Res. 2019. PMID: 31433868 Free article.
Combined with clinical data, 26 (15.0%) cases of DiGeorge syndrome (OMIM #188400), nine (5.2%) autoimmune polyglandular syndrome type 1 (OMIM #240300), eight (4.6%) autosomal dominant hypocalcemia type 1 (OMIM #601198), four (2.3%) hypoparathyro …
Combined with clinical data, 26 (15.0%) cases of DiGeorge syndrome (OMIM #188400), nine (5.2%) autoimmune polyglandular syndrome type 1 …