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Page 1
Cerebral cavernous malformation: Management, outcomes, and surveillance strategies - A single centre retrospective cohort study.
Hill CS, Borg A, Horsfall HL, Al-Mohammad A, Grover P, Kitchen N. Hill CS, et al. Clin Neurol Neurosurg. 2023 Feb;225:107576. doi: 10.1016/j.clineuro.2022.107576. Epub 2022 Dec 26. Clin Neurol Neurosurg. 2023. PMID: 36608471
BACKGROUND: Cerebral cavernous malformations (CCM) may undergo a period of clinical and/or radiographical surveillance that precedes or follows definitive treatment. ...
BACKGROUND: Cerebral cavernous malformations (CCM) may undergo a period of clinical and/or radiographical surveillance that pr …
Evaluating strategies for the treatment of cerebral cavernous malformations.
Li DY, Whitehead KJ. Li DY, et al. Stroke. 2010 Oct;41(10 Suppl):S92-4. doi: 10.1161/STROKEAHA.110.594929. Stroke. 2010. PMID: 20876517 Free PMC article. Review.
A recurring theme dominating the recent scientific literature is the causal link between mutations in the 3 cerebral cavernous malformation genes and hyperactivation of the small GTP exchange protein, RhoA, and the efficacy of reducing this hyperactivation us …
A recurring theme dominating the recent scientific literature is the causal link between mutations in the 3 cerebral cavernous …
Comparative studies of the diagnosis and treatment of cerebral cavernous malformations in adults: systematic review.
Poorthuis M, Samarasekera N, Kontoh K, Stuart I, Cope B, Kitchen N, Al-Shahi Salman R. Poorthuis M, et al. Acta Neurochir (Wien). 2013 Apr;155(4):643-9. doi: 10.1007/s00701-013-1621-4. Epub 2013 Jan 31. Acta Neurochir (Wien). 2013. PMID: 23371401 Review.
BACKGROUND: Cerebral cavernous malformation (CCM) management decisions are usually made after CCM diagnosis is suspected or definitively diagnosed on axial imaging by indirectly comparing a surgeon's estimate of operative morbidity and mortality against publi …
BACKGROUND: Cerebral cavernous malformation (CCM) management decisions are usually made after CCM diagnosis is suspecte …
Genetic Screening of Pediatric Cavernous Malformations.
Merello E, Pavanello M, Consales A, Mascelli S, Raso A, Accogli A, Cama A, Valeria C, De Marco P. Merello E, et al. J Mol Neurosci. 2016 Oct;60(2):232-8. doi: 10.1007/s12031-016-0806-8. Epub 2016 Aug 25. J Mol Neurosci. 2016. PMID: 27561926
Cerebral cavernous malformations (CCMs) are vascular malformations mostly located within the central nervous system. ...Similar to other CCM pediatric series, the main symptoms associated to clinical debut consisted of cerebral hemorrhage. In conclusion, the …
Cerebral cavernous malformations (CCMs) are vascular malformations mostly located within the central nervous system. ...Simila …
Familial cerebral cavernous malformations: Rio de Janeiro study and review of the recommendations for management.
Domingues F, Gasparetto EL, Andrade R, Noro F, Eiras A, Gault J, Correia CE, de Souza JM. Domingues F, et al. Arq Neuropsiquiatr. 2008 Dec;66(4):795-9. doi: 10.1590/s0004-282x2008000600003. Arq Neuropsiquiatr. 2008. PMID: 19099113 Free article. Review.
OBJECTIVE: Multiple cerebral cavernous malformation (CCM) is the hallmark of familial presentation of cavernous malformation in the brain. ...Familial cavernous malformation are to be settled apart from the more common sporadic les …
OBJECTIVE: Multiple cerebral cavernous malformation (CCM) is the hallmark of familial presentation of cavernous …
Biological Activities, Health Benefits, and Therapeutic Properties of Avenanthramides: From Skin Protection to Prevention and Treatment of Cerebrovascular Diseases.
Perrelli A, Goitre L, Salzano AM, Moglia A, Scaloni A, Retta SF. Perrelli A, et al. Oxid Med Cell Longev. 2018 Aug 23;2018:6015351. doi: 10.1155/2018/6015351. eCollection 2018. Oxid Med Cell Longev. 2018. PMID: 30245775 Free PMC article. Review.
In this review, we report on the biological activities of avenanthramides and their derivatives, including analogs produced in recombinant yeast, with a major focus on the therapeutic potential of these secondary metabolites in the treatment of aging-related human diseases …
In this review, we report on the biological activities of avenanthramides and their derivatives, including analogs produced in recombinant y …
Next Generation Sequencing (NGS) Strategies for Genetic Testing of Cerebral Cavernous Malformation (CCM) Disease.
Benedetti V, Pellegrino E, Brusco A, Piva R, Retta SF. Benedetti V, et al. Methods Mol Biol. 2020;2152:59-75. doi: 10.1007/978-1-0716-0640-7_5. Methods Mol Biol. 2020. PMID: 32524544
Reporting large CES series can improve guidelines on best practices for test utilization, and a better variant interpretation through clinically oriented data sharing.Herein, we suggest a feasible CES procedure for the genetic testing of Cerebral Cavernous Malfor …
Reporting large CES series can improve guidelines on best practices for test utilization, and a better variant interpretation through clinic …
Morbidity After Symptomatic Hemorrhage of Cerebral Cavernous Malformation: A Nomogram Approach to Risk Assessment.
Ma L, Zhang S, Li Z, Wu CX, Wang Z, Zhan L, Hao Q, Wang H, Ye X, Chen X, Liu YO, Wang S, Zhao YL. Ma L, et al. Stroke. 2020 Oct;51(10):2997-3006. doi: 10.1161/STROKEAHA.120.029942. Epub 2020 Sep 21. Stroke. 2020. PMID: 32951540
BACKGROUND AND PURPOSE: Symptomatic hemorrhage contributes to an increased risk of repeated bleeding and morbidity in cerebral cavernous malformation (CCM). A better understanding of morbidity after CCM hemorrhage would be helpful to identify patients of high …
BACKGROUND AND PURPOSE: Symptomatic hemorrhage contributes to an increased risk of repeated bleeding and morbidity in cerebral cav …
Strategy for identifying repurposed drugs for the treatment of cerebral cavernous malformation.
Gibson CC, Zhu W, Davis CT, Bowman-Kirigin JA, Chan AC, Ling J, Walker AE, Goitre L, Delle Monache S, Retta SF, Shiu YT, Grossmann AH, Thomas KR, Donato AJ, Lesniewski LA, Whitehead KJ, Li DY. Gibson CC, et al. Circulation. 2015 Jan 20;131(3):289-99. doi: 10.1161/CIRCULATIONAHA.114.010403. Epub 2014 Dec 8. Circulation. 2015. PMID: 25486933 Free PMC article.
BACKGROUND: Cerebral cavernous malformation (CCM) is a hemorrhagic stroke disease affecting up to 0.5% of North Americans that has no approved nonsurgical treatment. ...Each drug decreased lesion burden in a mouse model of CCM vascular disease by 50%. CONCLUS …
BACKGROUND: Cerebral cavernous malformation (CCM) is a hemorrhagic stroke disease affecting up to 0.5% of North America …
A review of contemporary options for medical management of hemangiomas, other vascular tumors, and vascular malformations.
Blatt J, McLean TW, Castellino SM, Burkhart CN. Blatt J, et al. Pharmacol Ther. 2013 Sep;139(3):327-33. doi: 10.1016/j.pharmthera.2013.05.001. Epub 2013 May 8. Pharmacol Ther. 2013. PMID: 23665062 Review.
With growing pharmacologic options and parallels to cancer treatment and biology, the hematologist-oncologist has assumed a more prominent role in clinical care and research relating to these diagnoses. This also is a growing area for targeted therapies and drug rep …
With growing pharmacologic options and parallels to cancer treatment and biology, the hematologist-oncologist has assumed a more prominent r …
13 results