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Page 1
Infections in activated PI3K delta syndrome (APDS).
Brodsky NN, Lucas CL. Brodsky NN, et al. Curr Opin Immunol. 2021 Oct;72:146-157. doi: 10.1016/j.coi.2021.04.010. Epub 2021 May 27. Curr Opin Immunol. 2021. PMID: 34052541 Review.
Activated PI3K-delta Syndrome (APDS), also called PI3K-delta activating mutation causing senescent T cells, lymphadenopathy, and immunodeficiency (PASLI), is an autosomal dominant disorder caused by inherited or de novo gain-of-function mutations in on …
Activated PI3K-delta Syndrome (APDS), also called PI3K-delta activating mutation causing senescent T cells, lymp …
Case report on activated PI3K-delta syndrome.
Crisanto-López IE, Pérez-Arzola AA, Hernández-Castañeda Y, Carrasco-Trinidad RG, Vera-Loaiza A, Jiménez-Pérez B, Guzmán-Santiago TA, Rodríguez-Hurtado PO, Salazar-Bonilla W, Juárez-Melchor D. Crisanto-López IE, et al. Bol Med Hosp Infant Mex. 2024;81(4):245-249. doi: 10.24875/BMHIM.23000124. Bol Med Hosp Infant Mex. 2024. PMID: 39236673 Free article. English.
PI3K in T Cell Adhesion and Trafficking.
Johansen KH, Golec DP, Thomsen JH, Schwartzberg PL, Okkenhaug K. Johansen KH, et al. Front Immunol. 2021 Aug 6;12:708908. doi: 10.3389/fimmu.2021.708908. eCollection 2021. Front Immunol. 2021. PMID: 34421914 Free PMC article. Review.
Furthermore, characterisation of patients with Activated PI3K Delta Syndrome (APDS) and mouse models with hyperactive PI3Kdelta have shed light on how increased PI3Kdelta activity affects T cell functions. ...
Furthermore, characterisation of patients with Activated PI3K Delta Syndrome (APDS) and mouse models with hypera …
Phosphoinositide 3-kinase δ (PI3Kδ) in respiratory disease.
Stokes CA, Condliffe AM. Stokes CA, et al. Biochem Soc Trans. 2018 Apr 17;46(2):361-369. doi: 10.1042/BST20170467. Epub 2018 Mar 9. Biochem Soc Trans. 2018. PMID: 29523773 Review.
We also describe the importance of PI3Kdelta in adaptive immune cell function, as highlighted by the recently described Activated PI3K Delta Syndrome, and draw attention to some of the potential clinical applications and benefits of targeting this mole …
We also describe the importance of PI3Kdelta in adaptive immune cell function, as highlighted by the recently described Activated …
T and B-cell signaling in activated PI3K delta syndrome: From immunodeficiency to autoimmunity.
Preite S, Gomez-Rodriguez J, Cannons JL, Schwartzberg PL. Preite S, et al. Immunol Rev. 2019 Sep;291(1):154-173. doi: 10.1111/imr.12790. Immunol Rev. 2019. PMID: 31402502 Review.
In this article, we discuss how studies on the human genetic disorder "Activated PI3K-delta syndrome" and mouse models of this disease (Pik3cd(E1020K/+) mice) have provided fundamental insight into pathways regulated by PI3Kdelta in T and B cells and t …
In this article, we discuss how studies on the human genetic disorder "Activated PI3K-delta syndrome" and mouse …
52 results