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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2001 3
2002 1
2003 1
2004 3
2005 2
2006 3
2007 3
2008 2
2009 4
2010 3
2011 7
2012 2
2014 1
2015 10
2016 7
2017 10
2018 2
2019 3
2020 7
2021 7
2022 6
2023 3
2024 2

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80 results

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Page 1
Mitochondria-ER contact mediated by MFN2-SERCA2 interaction supports CD8+ T cell metabolic fitness and function in tumors.
Yang JF, Xing X, Luo L, Zhou XW, Feng JX, Huang KB, Liu H, Jin S, Liu YN, Zhang SH, Pan YH, Yu B, Yang JY, Cao YL, Cao Y, Yang CY, Wang Y, Zhang Y, Li J, Xia X, Kang T, Xu RH, Lan P, Luo JH, Han H, Bai F, Gao S. Yang JF, et al. Sci Immunol. 2023 Sep 29;8(87):eabq2424. doi: 10.1126/sciimmunol.abq2424. Epub 2023 Sep 22. Sci Immunol. 2023. PMID: 37738362
In this study, we show that mitofusin-2 (MFN2) expression is positively correlated with the prognosis of multiple cancers. Genetic ablation of Mfn2 in CD8(+) T cells dampens mitochondrial metabolism and function and promotes tumor progression. ...Elevating mitochondria-ER …
In this study, we show that mitofusin-2 (MFN2) expression is positively correlated with the prognosis of multiple cancers. Genetic ab …
Alterations in the ATP2A2 gene in correlation with colon and lung cancer.
Korosec B, Glavac D, Rott T, Ravnik-Glavac M. Korosec B, et al. Cancer Genet Cytogenet. 2006 Dec;171(2):105-11. doi: 10.1016/j.cancergencyto.2006.06.016. Cancer Genet Cytogenet. 2006. PMID: 17116488

We found 13 different novel alterations of the ATP2A2 gene in 27 of 416 alleles of patients with two different types of cancer. Changes in ATP2A2 were significantly more common in patients with colon cancer (P < 0.0001, odds ratio OR = 25.3) or lung

…
We found 13 different novel alterations of the ATP2A2 gene in 27 of 416 alleles of patients with two different types of cancer …
Association of Somatic ATP2A2 Damaging Variants With Grover Disease.
Seli D, Ellis KT, Goldust M, Shah K, Hu R, Zhou J, McNiff JM, Choate KA. Seli D, et al. JAMA Dermatol. 2023 Jul 1;159(7):745-749. doi: 10.1001/jamadermatol.2023.1139. JAMA Dermatol. 2023. PMID: 37195706 Free PMC article.
In 9 cases (75%), the GD-associated ATP2A2 SNV was absent from control tissue DNA, and in 3 cases (25%), ATP2A2 SNVs were enriched 4- to 22-fold in GD vs control tissue. CONCLUSIONS AND RELEVANCE: In this case series study of 15 patients, damaging somatic ATP2A2 …
In 9 cases (75%), the GD-associated ATP2A2 SNV was absent from control tissue DNA, and in 3 cases (25%), ATP2A2 SNVs were enri …
Calcium-ATPases: Gene disorders and dysregulation in cancer.
Dang D, Rao R. Dang D, et al. Biochim Biophys Acta. 2016 Jun;1863(6 Pt B):1344-50. doi: 10.1016/j.bbamcr.2015.11.016. Epub 2015 Nov 30. Biochim Biophys Acta. 2016. PMID: 26608610 Free PMC article. Review.
Emerging evidence points to an important function of dysregulated Ca(2+)-ATPase expression in cancers of the colon, lung, and breast where they may serve as markers of differentiation or novel targets for therapeutic intervention. We review the mechanisms underlying the li …
Emerging evidence points to an important function of dysregulated Ca(2+)-ATPase expression in cancers of the colon, lung, and breast …
High ATP2A2 expression correlates with better prognosis of diffuse astrocytic tumor patients.
Li WQ, Zhong NZ, He J, Li YM, Hou LJ, Liu HM, Xia CY, Wang LZ, Lu YC. Li WQ, et al. Oncol Rep. 2017 May;37(5):2865-2874. doi: 10.3892/or.2017.5528. Epub 2017 Mar 24. Oncol Rep. 2017. PMID: 28339043
The median survival was 455.3 (95% CI, 34.7-55.3) months in patients with high ATP2A2 expression and 165.0 (95% CI, 6.3-25.7) months in patients with low ATP2A2 expression (P<0.0001). ...Our findings identified high ATP2A2 expression in a subset of astrocy …
The median survival was 455.3 (95% CI, 34.7-55.3) months in patients with high ATP2A2 expression and 165.0 (95% CI, 6.3-25.7) months …
MicroRNA-200c-3p Negatively Regulates ATP2A2 and Promotes the Progression of Papillary Thyroid Carcinoma.
Feng YL, Ke T, Wang GL, Qi HY, Xiao Y. Feng YL, et al. Biochem Genet. 2022 Oct;60(5):1676-1694. doi: 10.1007/s10528-022-10184-w. Epub 2022 Jan 25. Biochem Genet. 2022. PMID: 35079913 Free PMC article.
The effects of miR-200c-3p mimics on promoting the malignant behaviors of PTC cells were remarkably reversed by the overexpression of ATP2A2, as a downstream target of miR-200c-3p. miR-200c-3p acts as an oncogenic gene and promotes the malignant biological behaviors of hum …
The effects of miR-200c-3p mimics on promoting the malignant behaviors of PTC cells were remarkably reversed by the overexpression of ATP …
ATP2A3 gene is involved in cancer susceptibility.
Korosec B, Glavac D, Volavsek M, Ravnik-Glavac M. Korosec B, et al. Cancer Genet Cytogenet. 2009 Jan 15;188(2):88-94. doi: 10.1016/j.cancergencyto.2008.10.007. Cancer Genet Cytogenet. 2009. PMID: 19100511
The sarco/endoplasmatic reticulum calcium-ATPase (SERCA) translocates Ca(2+) from cytosol to the lumen of the ER and thus regulates Ca(2+) homeostasis, perturbations of which have been suggested to contribute to cancer. We have previously detected an increased number of al …
The sarco/endoplasmatic reticulum calcium-ATPase (SERCA) translocates Ca(2+) from cytosol to the lumen of the ER and thus regulates Ca(2+) h …
EVI2B, ATP2A2, S100B, TM4SF3, and OLFM4 as potential prognostic markers for postoperative Taiwanese colorectal cancer patients.
Huang MY, Wang HM, Tok TS, Chang HJ, Chang MS, Cheng TL, Wang JY, Lin SR. Huang MY, et al. DNA Cell Biol. 2012 Apr;31(4):625-35. doi: 10.1089/dna.2011.1365. Epub 2011 Nov 2. DNA Cell Biol. 2012. PMID: 22047082
Postoperative relapse was significantly correlated with gene overexpression, including EVI2B (p=0.001, OR=4.622), ATP2A2 (p=0.006, OR=4.688), S100B (p=0.001, OR=11.521), TM4SF3 (p=0.001, OR=6.756), and OLFM4 (p=0.008, OR=3.545). Using WEnCA (weighting score of each gene: 5 …
Postoperative relapse was significantly correlated with gene overexpression, including EVI2B (p=0.001, OR=4.622), ATP2A2 (p=0.006, OR …
Proteogenomic landscape and clinical characterization of GH-producing pituitary adenomas/somatotroph pituitary neuroendocrine tumors.
Yamato A, Nagano H, Gao Y, Matsuda T, Hashimoto N, Nakayama A, Yamagata K, Yokoyama M, Gong Y, Shi X, Zhahara SN, Kono T, Taki Y, Furuki N, Nishimura M, Horiguchi K, Iwadate Y, Fukuyo M, Rahmutulla B, Kaneda A, Hasegawa Y, Kawashima Y, Ohara O, Ishikawa T, Kawakami E, Nakamura Y, Inoshita N, Yamada S, Fukuhara N, Nishioka H, Tanaka T. Yamato A, et al. Commun Biol. 2022 Nov 27;5(1):1304. doi: 10.1038/s42003-022-04272-1. Commun Biol. 2022. PMID: 36435867 Free PMC article.
The results suggested that GNAS mutations impact endocrinological features in acromegaly through GPCR pathway induction. ATP2A2 and ARID5B correlated with the GH change rate in the octreotide loading test, and WWC3, SERINC1, and ZFAND3 correlated with the tumor volume chan …
The results suggested that GNAS mutations impact endocrinological features in acromegaly through GPCR pathway induction. ATP2A2 and A …
NF-YA overexpression protects from glutamine deprivation.
Dolfini D, Minuzzo M, Sertic S, Mantovani R. Dolfini D, et al. Biochim Biophys Acta Mol Cell Res. 2020 Feb;1867(2):118571. doi: 10.1016/j.bbamcr.2019.118571. Epub 2019 Nov 9. Biochim Biophys Acta Mol Cell Res. 2020. PMID: 31706909 Free article.
The work represents a proof-of-principle that elevated levels of NF-YA, as found in some tumor types, helps altering cancer metabolic pathways....
The work represents a proof-of-principle that elevated levels of NF-YA, as found in some tumor types, helps altering cancer metabolic …
80 results