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Antisense therapeutics.
Agrawal S, Zhao Q. Agrawal S, et al. Curr Opin Chem Biol. 1998 Aug;2(4):519-28. doi: 10.1016/s1367-5931(98)80129-4. Curr Opin Chem Biol. 1998. PMID: 9736926 Review.
Mixed backbone antisense oligonucleotides: design, biochemical and biological properties of oligonucleotides containing 2'-5'-ribo- and 3'-5'-deoxyribonucleotide segments.
Kandimalla ER, Manning A, Zhao Q, Shaw DR, Byrn RA, Sasisekharan V, Agrawal S. Kandimalla ER, et al. Among authors: agrawal s. Nucleic Acids Res. 1997 Jan 15;25(2):370-8. doi: 10.1093/nar/25.2.370. Nucleic Acids Res. 1997. PMID: 9016567 Free PMC article.
Increasing the number of 2'-5'linkages (from six to nine) further reduces binding to the DNA target strand more than the RNA target strand [Kandimalla,E.R. and Agrawal,S. (1996)Nucleic Acids Symp. Ser., 35, 125-126]. Phosphorothioate (PS) analogs of MBOs destabilize …
Increasing the number of 2'-5'linkages (from six to nine) further reduces binding to the DNA target strand more than the RNA target strand [ …
4,050 results