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miR-142-3p attenuates breast cancer stem cell characteristics and decreases radioresistance in vitro.
Troschel FM, Böhly N, Borrmann K, Braun T, Schwickert A, Kiesel L, Eich HT, Götte M, Greve B. Troschel FM, et al. Tumour Biol. 2018 Aug;40(8):1010428318791887. doi: 10.1177/1010428318791887. Tumour Biol. 2018. PMID: 30091683 Free article.
Radiation response was investigated by colony formation assays. Levels of BRCA1, BRCA2, and Bod1 in miR-142-3p-overexpressing cells as well as expression of miR-142-3p, Bod1, KLF4, and Oct4 in sorted CD44(+)/CD24(-/low) cells were determined by quantitative polymera …
Radiation response was investigated by colony formation assays. Levels of BRCA1, BRCA2, and Bod1 in miR-142-3p-overexpressing cells a …
Bod1 regulates protein phosphatase 2A at mitotic kinetochores.
Porter IM, Schleicher K, Porter M, Swedlow JR. Porter IM, et al. Nat Commun. 2013;4:2677. doi: 10.1038/ncomms3677. Nat Commun. 2013. PMID: 24157919 Free PMC article.
PP2A-B56 regulates the stability of kinetochore-microtubule attachments by dephosphorylating several kinetochore proteins. Loss of Bod1 changes the balance of phosphorylation at kinetochores, causing defects in kinetochore function. Bod1, Ensa and Arpp-19 define a f …
PP2A-B56 regulates the stability of kinetochore-microtubule attachments by dephosphorylating several kinetochore proteins. Loss of Bod1 …
Radiation induces premature chromatid separation via the miR-142-3p/Bod1 pathway in carcinoma cells.
Pan D, Du Y, Ren Z, Chen Y, Li X, Wang J, Hu B. Pan D, et al. Oncotarget. 2016 Sep 13;7(37):60432-60445. doi: 10.18632/oncotarget.11080. Oncotarget. 2016. PMID: 27527863 Free PMC article.
Radiation-induced genomic instability plays a vital role in carcinogenesis. Bod1 is required for proper chromosome biorientation, and Bod1 depletion increases premature chromatid separation. ...Combining ionizing radiation with epigenetic regulation may help improve …
Radiation-induced genomic instability plays a vital role in carcinogenesis. Bod1 is required for proper chromosome biorientation, and …
Bod1, a novel kinetochore protein required for chromosome biorientation.
Porter IM, McClelland SE, Khoudoli GA, Hunter CJ, Andersen JS, McAinsh AD, Blow JJ, Swedlow JR. Porter IM, et al. J Cell Biol. 2007 Oct 22;179(2):187-97. doi: 10.1083/jcb.200704098. Epub 2007 Oct 15. J Cell Biol. 2007. PMID: 17938248 Free PMC article.
Small interfering RNA depletion of Bod1 in HeLa cells produces elongated mitotic spindles with severe biorientation defects. ...Therefore, Bod1 is a novel kinetochore protein that is required for the detection or resolution of syntelic attachments in mitotic spindle …
Small interfering RNA depletion of Bod1 in HeLa cells produces elongated mitotic spindles with severe biorientation defects. ...There …
Exploring the logic and conducting a comprehensive evaluation of AdipoRon-based adiponectin replacement therapy against hormone-related cancers-a systematic review.
Laurindo LF, Sosin AF, Lamas CB, de Alvares Goulart R, Dos Santos Haber JF, Detregiachi CRP, Barbalho SM. Laurindo LF, et al. Naunyn Schmiedebergs Arch Pharmacol. 2024 Apr;397(4):2067-2082. doi: 10.1007/s00210-023-02792-z. Epub 2023 Oct 21. Naunyn Schmiedebergs Arch Pharmacol. 2024. PMID: 37864589 Review.
While researchers have explored the efficacy and therapeutic applications of AdipoRon in various disease conditions, their effects against cancer models advanced more, with no review regarding AdipoRon's efficacy against hormone-related cancers being published. ...I …
While researchers have explored the efficacy and therapeutic applications of AdipoRon in various disease conditions, their effects against …
Bioinformatics Analysis Using ATAC-seq and RNA-seq for the Identification of 15 Gene Signatures Associated With the Prediction of Prognosis in Hepatocellular Carcinoma.
Yang H, Li G, Qiu G. Yang H, et al. Front Oncol. 2021 Oct 25;11:726551. doi: 10.3389/fonc.2021.726551. eCollection 2021. Front Oncol. 2021. PMID: 34760691 Free PMC article.
RESULTS: ATAC-seq, RNA-seq and survival analysis, combined with a LASSO prediction model, identified signatures of 15 genes (PRDX6, GCLM, HTATIP2, SEMA3F, UCK2, NOL10, KIF18A, RAP2A, BOD1, GDI2, ZIC2, GTF3C6 SLC1A5, ERI3 and SAC3D1), all of which were highly expressed in h …
RESULTS: ATAC-seq, RNA-seq and survival analysis, combined with a LASSO prediction model, identified signatures of 15 genes (PRDX6, GCLM, HT …
A cytoplasmic COMPASS is necessary for cell survival and triple-negative breast cancer pathogenesis by regulating metabolism.
Wang L, Collings CK, Zhao Z, Cozzolino KA, Ma Q, Liang K, Marshall SA, Sze CC, Hashizume R, Savas JN, Shilatifard A. Wang L, et al. Genes Dev. 2017 Oct 15;31(20):2056-2066. doi: 10.1101/gad.306092.117. Epub 2017 Nov 14. Genes Dev. 2017. PMID: 29138278 Free PMC article.
Loss of SET1B or its unique cytoplasmic-interacting protein, BOD1, leads to up-regulation of expression of numerous genes modulating fatty acid metabolism, including ADIPOR1 (adiponectin receptor 1), COX7C, SDC4, and COQ7 Our detailed molecular studies identify ADIPOR1 sig …
Loss of SET1B or its unique cytoplasmic-interacting protein, BOD1, leads to up-regulation of expression of numerous genes modulating …
Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes.
van Nuland R, Smits AH, Pallaki P, Jansen PW, Vermeulen M, Timmers HT. van Nuland R, et al. Mol Cell Biol. 2013 May;33(10):2067-77. doi: 10.1128/MCB.01742-12. Epub 2013 Mar 18. Mol Cell Biol. 2013. PMID: 23508102 Free PMC article.
In addition to being a core COMPASS subunit, the Dpy30 protein is a genuine subunit of the NURF chromatin remodeling complex. Furthermore, we identified the Bod1 protein as a discriminator between the SET1B and SET1A complexes, and we show that the H3K36me-interactor Psip1 …
In addition to being a core COMPASS subunit, the Dpy30 protein is a genuine subunit of the NURF chromatin remodeling complex. Furthermore, w …
Genetic And Environmental Associations Of Nonspecific Chromosomal Aberrations.
Hemminki K, Niazi Y, Vodickova L, Vodicka P, Försti A. Hemminki K, et al. Mutagenesis. 2024 Feb 29:geae006. doi: 10.1093/mutage/geae006. Online ahead of print. Mutagenesis. 2024. PMID: 38422374
Previous studies on occupationally exposed individuals have shown associations between the frequency of CAs in peripheral blood lymphocytes and subsequent cancer risk. The cause for CA formation are believed to be unrepaired or insufficiently repaired DNA double-strand bre …
Previous studies on occupationally exposed individuals have shown associations between the frequency of CAs in peripheral blood lymphocytes …
11 results