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Showing results for kathleen sickles
Your search for Cathleen Sickles retrieved no results
Medication adherence among pediatric patients with sickle cell disease: a systematic review.
Walsh KE, Cutrona SL, Kavanagh PL, Crosby LE, Malone C, Lobner K, Bundy DG. Walsh KE, et al. Pediatrics. 2014 Dec;134(6):1175-83. doi: 10.1542/peds.2014-0177. Epub 2014 Nov 17. Pediatrics. 2014. PMID: 25404717 Free PMC article. Review.
OBJECTIVES: Describe rates of adherence for sickle cell disease (SCD) medications, identify patient and medication characteristics associated with nonadherence, and determine the effect of nonadherence and moderate adherence (defined as taking 60%-80% of doses) on clinical …
OBJECTIVES: Describe rates of adherence for sickle cell disease (SCD) medications, identify patient and medication characteristics as …
A phase 1 study in healthy participants to characterize the safety and pharmacology of inclacumab, a fully human anti-P-selectin antibody, in development for treatment of sickle cell disease.
Mayer CL, Koeck K, Hottmann M, Redfern A, Davis M, Barth A, Geng X, Hoppe C, Yue P. Mayer CL, et al. Eur J Clin Pharmacol. 2023 Sep;79(9):1219-1228. doi: 10.1007/s00228-023-03514-3. Epub 2023 Jul 12. Eur J Clin Pharmacol. 2023. PMID: 37436495 Free PMC article. Clinical Trial.
PURPOSE: We evaluated the safety, pharmacokinetics (PK), pharmacodynamics (PD), and immunogenicity of intravenous (IV) inclacumab, a fully human IgG4 anti-P-selectin monoclonal antibody in development for the treatment of sickle cell disease, at doses up to and exceeding t …
PURPOSE: We evaluated the safety, pharmacokinetics (PK), pharmacodynamics (PD), and immunogenicity of intravenous (IV) inclacumab, a fully h …
Validation of patient-reported vaso-occlusive crisis day as an endpoint in sickle cell disease studies.
Coyne KS, Currie BM, Callaghan M, Wyrwich KW, Pease S, Baker CL, Arkin S, Pittman DD. Coyne KS, et al. Eur J Haematol. 2022 Sep;109(3):226-237. doi: 10.1111/ejh.13790. Epub 2022 Jun 20. Eur J Haematol. 2022. PMID: 35569114 Free PMC article.
Individuals with sickle cell disease (SCD) experience vaso-occlusive crises (VOC). ...In order to validate a daily patient-reported outcome for patients with SCD to accurately report their VOC status and experience of a pain crisis, a SCD Diary was included in Evaluation o …
Individuals with sickle cell disease (SCD) experience vaso-occlusive crises (VOC). ...In order to validate a daily patient-reported o …
Impact of voxelotor (GBT440) on unconjugated bilirubin and jaundice in sickle cell disease.
Telfer P, Agodoa I, Fox KM, Burke L, Mant T, Jurek M, Tonda M, Lehrer-Graiwer J. Telfer P, et al. Hematol Rep. 2018 May 22;10(2):7643. doi: 10.4081/hr.2018.7643. eCollection 2018 May 14. Hematol Rep. 2018. PMID: 30046415 Free PMC article.
For many patients with sickle cell disease (SCD), jaundice is a significant clinical disease manifestation that impacts on patient well-being. ...
For many patients with sickle cell disease (SCD), jaundice is a significant clinical disease manifestation that impacts on patient we …
Hydroxycarbamide treatment and brain MRI/MRA findings in children with sickle cell anaemia.
Nottage KA, Ware RE, Aygun B, Smeltzer M, Kang G, Moen J, Wang WC, Hankins JS, Helton KJ. Nottage KA, et al. Br J Haematol. 2016 Oct;175(2):331-338. doi: 10.1111/bjh.14235. Epub 2016 Sep 8. Br J Haematol. 2016. PMID: 27604981 Free article.
Silent cerebral infarction (SCI) is the most common neurological abnormality among children with sickle cell anaemia (SCA). The effect of hydroxycarbamide (also termed hydroxyurea) on the development and progression of SCI is unclear. ...
Silent cerebral infarction (SCI) is the most common neurological abnormality among children with sickle cell anaemia (SCA). The effec …
Psychometric analysis of the adult sickle cell quality of life measurement information system (ACSQ-Me) in a UK population.
Cooper O, McBain H, Tangayi S, Telfer P, Tsitsikas D, Yardumian A, Mulligan K. Cooper O, et al. Health Qual Life Outcomes. 2019 Apr 29;17(1):74. doi: 10.1186/s12955-019-1136-7. Health Qual Life Outcomes. 2019. PMID: 31036017 Free PMC article.
BACKGROUND: The Adult Sickle Cell Quality of Life Measurement Information System (ASCQ-Me) has been shown to be a reliable and valid questionnaire measuring health-related quality of life (HRQoL) in the US sickle cell disease (SCD) population. ...
BACKGROUND: The Adult Sickle Cell Quality of Life Measurement Information System (ASCQ-Me) has been shown to be a reliable and valid …
Evaluation of SWI in children with sickle cell disease.
Winchell AM, Taylor BA, Song R, Loeffler RB, Grundlehner P, Hankins JS, Wang WC, Ogg RJ, Hillenbrand CM, Helton KJ. Winchell AM, et al. AJNR Am J Neuroradiol. 2014 May;35(5):1016-21. doi: 10.3174/ajnr.A3794. Epub 2013 Nov 21. AJNR Am J Neuroradiol. 2014. PMID: 24263696 Free PMC article.
The SWI venous contrast is affected by blood flow, which may be altered in sickle cell disease. In this study, we characterized SWI venous contrast in patients with sickle cell disease and healthy control participants and examined the relationships among SWI venous …
The SWI venous contrast is affected by blood flow, which may be altered in sickle cell disease. In this study, we characterized SWI v …
Arterial spin-labeled perfusion combined with segmentation techniques to evaluate cerebral blood flow in white and gray matter of children with sickle cell anemia.
Helton KJ, Paydar A, Glass J, Weirich EM, Hankins J, Li CS, Smeltzer MP, Wang WC, Ware RE, Ogg RJ. Helton KJ, et al. Pediatr Blood Cancer. 2009 Jan;52(1):85-91. doi: 10.1002/pbc.21745. Pediatr Blood Cancer. 2009. PMID: 18937311 Free PMC article.
BACKGROUND: Changes in cerebral perfusion are an important feature of the pathophysiology of sickle cell anemia (SCA); cerebrovascular ischemia occurs frequently and leads to neurocognitive deficits, silent infarcts, and overt stroke. ...
BACKGROUND: Changes in cerebral perfusion are an important feature of the pathophysiology of sickle cell anemia (SCA); cerebrovascula …
Factors that influence adolescent adaptation to sickle cell disease.
Burlew K, Telfair J, Colangelo L, Wright EC. Burlew K, et al. J Pediatr Psychol. 2000 Jul-Aug;25(5):287-99. doi: 10.1093/jpepsy/25.5.287. J Pediatr Psychol. 2000. PMID: 10880059
OBJECTIVE: To examine whether psychosocial factors play a more important role than biomedical risk factors in predicting adolescent adaptation to sickle cell disease (SCD); to determine whether psychosocial factors moderate the relationship between biomedical risk factors …
OBJECTIVE: To examine whether psychosocial factors play a more important role than biomedical risk factors in predicting adolescent adaptati …