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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1982 1
1983 8
1984 35
1985 61
1986 75
1987 70
1988 67
1989 18
1990 13
1991 16
1992 26
1993 21
1994 24
1995 31
1996 38
1997 38
1998 46
1999 57
2000 84
2001 72
2002 102
2003 102
2004 104
2005 147
2006 142
2007 160
2008 155
2009 192
2010 210
2011 211
2012 221
2013 234
2014 205
2015 240
2016 246
2017 249
2018 251
2019 244
2020 257
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2022 334
2023 272
2024 123

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4,970 results

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Page 1
Nasopharyngeal carcinoma cells promote regulatory T cell development and suppressive activity via CD70-CD27 interaction.
Gong L, Luo J, Zhang Y, Yang Y, Li S, Fang X, Zhang B, Huang J, Chow LK, Chung D, Huang J, Huang C, Liu Q, Bai L, Tiu YC, Wu P, Wang Y, Tsao GS, Kwong DL, Lee AW, Dai W, Guan XY. Gong L, et al. Nat Commun. 2023 Apr 6;14(1):1912. doi: 10.1038/s41467-023-37614-6. Nat Commun. 2023. PMID: 37024479 Free PMC article.
We reveal that nasopharyngeal carcinoma cells enhance development and suppressive activity of regulatory T cells via CD70-CD27 interaction. CD70 blocking reverts Treg-mediated suppression and thus reinvigorate CD8+ T-cell immunity. ...
We reveal that nasopharyngeal carcinoma cells enhance development and suppressive activity of regulatory T cells via CD70-CD27 intera …
IgD(-)CD27(-) double negative (DN) B cells: Origins and functions in health and disease.
Beckers L, Somers V, Fraussen J. Beckers L, et al. Immunol Lett. 2023 Mar;255:67-76. doi: 10.1016/j.imlet.2023.03.003. Epub 2023 Mar 9. Immunol Lett. 2023. PMID: 36906182 Review.
Human B cells can be divided into four main subsets based on differential expression of immunoglobulin (Ig)D and CD27. IgD(-)CD27(-) double negative (DN) B cells make up a heterogeneous group of B cells that have first been described in relation to aging and systemi …
Human B cells can be divided into four main subsets based on differential expression of immunoglobulin (Ig)D and CD27. IgD(-)CD27 …
CD27 on human memory B cells-more than just a surface marker.
Grimsholm O. Grimsholm O. Clin Exp Immunol. 2023 Jul 21;213(2):164-172. doi: 10.1093/cei/uxac114. Clin Exp Immunol. 2023. PMID: 36508329 Free PMC article. Review.
While the heterogeneity of the human memory B-cell pool is still poorly understood, specific cellular surface markers define most of the cell subpopulations. CD27 is one of the most commonly used markers to define human memory B cells. ...In this review, I will focus on th …
While the heterogeneity of the human memory B-cell pool is still poorly understood, specific cellular surface markers define most of the cel …
New emerging targets in cancer immunotherapy: CD27 (TNFRSF7).
Starzer AM, Berghoff AS. Starzer AM, et al. ESMO Open. 2020 Mar;4(Suppl 3):e000629. doi: 10.1136/esmoopen-2019-000629. ESMO Open. 2020. PMID: 32152062 Free PMC article. Review.
The CD27 agonistic antibody varlilumab showed promising efficacy in haematological as well as solid cancers. ...In this mini review, we aimed to elucidate the immunobiology of CD27 and its potential as a target in cancer immunotherapy....
The CD27 agonistic antibody varlilumab showed promising efficacy in haematological as well as solid cancers. ...In this mini review, …
The role of CD27 in anti-viral T-cell immunity.
Grant EJ, Nüssing S, Sant S, Clemens EB, Kedzierska K. Grant EJ, et al. Curr Opin Virol. 2017 Feb;22:77-88. doi: 10.1016/j.coviro.2016.12.001. Epub 2017 Jan 12. Curr Opin Virol. 2017. PMID: 28086150 Review.
Limited in vitro human studies support mouse experiments and show that CD27 co-stimulation enhances antiviral T-cell immunity. Given the potent co-stimulatory effects of CD27, manipulating CD27 signalling is of interest for viral, autoimmune and anti-tumour i …
Limited in vitro human studies support mouse experiments and show that CD27 co-stimulation enhances antiviral T-cell immunity. Given …
Chronic CD27-CD70 costimulation promotes type 1-specific polarization of effector Tregs.
Bowakim-Anta N, Acolty V, Azouz A, Yagita H, Leo O, Goriely S, Oldenhove G, Moser M. Bowakim-Anta N, et al. Front Immunol. 2023 Mar 13;14:1023064. doi: 10.3389/fimmu.2023.1023064. eCollection 2023. Front Immunol. 2023. PMID: 36993956 Free PMC article.
INTRODUCTION: Most T lymphocytes, including regulatory T cells, express the CD27 costimulatory receptor in steady state conditions. There is evidence that CD27 engagement on conventional T lymphocytes favors the development of Th1 and cytotoxic responses in mice and …
INTRODUCTION: Most T lymphocytes, including regulatory T cells, express the CD27 costimulatory receptor in steady state conditions. T …
CD27 mRNA expression in mycosis fungoides.
Galliano I, Daprà V, Ponti R, Alliaudi C, Fierro MT, Quaglino P, Bergallo M. Galliano I, et al. Ital J Dermatol Venerol. 2022 Jun;157(3):275-280. doi: 10.23736/S2784-8671.21.06953-X. Epub 2021 Jul 20. Ital J Dermatol Venerol. 2022. PMID: 34282858
In this study, we examined the expression of CD27 in the skin of MF patients by real time PCR. The amount of CD27 was measured in MF patients and healthy controls. ...No difference was observed in the MF clustered by stages. CONCLUSIONS: Our findings indicates that …
In this study, we examined the expression of CD27 in the skin of MF patients by real time PCR. The amount of CD27 was measured …
The CD27-CD70 pathway and pathogenesis of autoimmune disease.
Han BK, Olsen NJ, Bottaro A. Han BK, et al. Semin Arthritis Rheum. 2016 Feb;45(4):496-501. doi: 10.1016/j.semarthrit.2015.08.001. Epub 2015 Aug 11. Semin Arthritis Rheum. 2016. PMID: 26359318 Review.
The membrane receptor CD27 and its soluble form (sCD27) transmit co-stimulatory signals and induce activation and proliferation of T and B lymphocytes. ...CONCLUSION: Current evidence from animal models and human diseases suggests that CD27-CD70 pathway contributes …
The membrane receptor CD27 and its soluble form (sCD27) transmit co-stimulatory signals and induce activation and proliferation of T …
The immunobiology of CD27 and OX40 and their potential as targets for cancer immunotherapy.
Buchan SL, Rogel A, Al-Shamkhani A. Buchan SL, et al. Blood. 2018 Jan 4;131(1):39-48. doi: 10.1182/blood-2017-07-741025. Epub 2017 Nov 8. Blood. 2018. PMID: 29118006 Free article. Review.
We here review the immunobiology of 2 particularly promising TNFRSF target receptors, CD27 and OX40, and their respective ligands, CD70 and OX40L, focusing on their role within a tumor setting. We describe the influence of CD27 and OX40 on human T cells based on in …
We here review the immunobiology of 2 particularly promising TNFRSF target receptors, CD27 and OX40, and their respective ligands, CD …
CD27 and CD70 in T cell and B cell activation.
Borst J, Hendriks J, Xiao Y. Borst J, et al. Curr Opin Immunol. 2005 Jun;17(3):275-81. doi: 10.1016/j.coi.2005.04.004. Curr Opin Immunol. 2005. PMID: 15886117 Review.
Recent studies, enforcing or abrogating CD27 function by genetic or protein intervention in mouse models have revealed key contributions of the CD27-CD70 system to effector and memory T cell formation, which is probably based on improved cell survival. ...Targeting …
Recent studies, enforcing or abrogating CD27 function by genetic or protein intervention in mouse models have revealed key contributi …
4,970 results