Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1981 1
1988 2
1989 2
1990 2
1991 2
1992 2
1993 4
1994 2
1995 8
1996 14
1997 19
1998 27
1999 30
2000 37
2001 33
2002 41
2003 38
2004 50
2005 41
2006 48
2007 42
2008 49
2009 46
2010 40
2011 35
2012 59
2013 38
2014 44
2015 38
2016 41
2017 49
2018 38
2019 40
2020 34
2021 53
2022 42
2023 42
2024 18

Text availability

Article attribute

Article type

Publication date

Search Results

1,083 results

Results by year

Filters applied: . Clear all
Page 1
CDC6 is a prognostic biomarker and correlated with immune infiltrates in glioma.
Wang F, Zhao F, Zhang L, Xiong L, Mao Q, Liu Y, Qiu X, Wang X, Shui L, Chen X, Ren K, Shui P, Zhang Q, Deng Y, Li W, Xie X, Wu D, Li T, Lang J, Liu L, Chen H, Xu J, Bai S, Li Z, Yue Q, Chen N, Zhou B, Yi C, Wei Y, Fu Y, Luo Y, Gou Q, Liu L, Liu Y, Kang J, Wang J, Jing D, Zhang F, Yang X, Li X, Jiang T, Zhang Z, Zhou Y, Yi J. Wang F, et al. Mol Cancer. 2022 Jul 25;21(1):153. doi: 10.1186/s12943-022-01623-8. Mol Cancer. 2022. PMID: 35879762 Free PMC article.
BACKGROUND: Cell division cycle 6 (CDC6) has been proven to be associated with the initiation and progression of human multiple tumors. ...RESULTS: As a result, CDC6 expression was upregulated in multiple types of cancer, including glioma. ...
BACKGROUND: Cell division cycle 6 (CDC6) has been proven to be associated with the initiation and progression of human multiple tumor …
LncRNA-CDC6 promotes breast cancer progression and function as ceRNA to target CDC6 by sponging microRNA-215.
Kong X, Duan Y, Sang Y, Li Y, Zhang H, Liang Y, Liu Y, Zhang N, Yang Q. Kong X, et al. J Cell Physiol. 2019 Jun;234(6):9105-9117. doi: 10.1002/jcp.27587. Epub 2018 Oct 26. J Cell Physiol. 2019. PMID: 30362551
Clinically, lncRNA-CDC6 was highly expressed in tumor tissues and was positively correlated with clinical stages of breast cancers. ...Moreover, lncRNA-CDC6 could function as competitive endogenous RNA (ceRNA) via directly sponging of microRNA-215 (miR-215), which f …
Clinically, lncRNA-CDC6 was highly expressed in tumor tissues and was positively correlated with clinical stages of breast cancers. . …
Cdc6 as a novel target in cancer: Oncogenic potential, senescence and subcellular localisation.
Lim N, Townsend PA. Lim N, et al. Int J Cancer. 2020 Sep 15;147(6):1528-1534. doi: 10.1002/ijc.32900. Epub 2020 Feb 17. Int J Cancer. 2020. PMID: 32010971 Free PMC article. Review.
Indeed, Cdc6 overexpression has been found to be a feature in certain tumours and has been associated as an early event in malignancies. ...In this review, we summarise the evidence for the role of Cdc6 overexpression in cancer, specifically that of pancreatic cance …
Indeed, Cdc6 overexpression has been found to be a feature in certain tumours and has been associated as an early event in malignanci …
Archaeal orc1/cdc6 proteins.
Bell SD. Bell SD. Subcell Biochem. 2012;62:59-69. doi: 10.1007/978-94-007-4572-8_4. Subcell Biochem. 2012. PMID: 22918580 Review.
The initiation of DNA replication in most archaeal genomes is mediated by proteins related to eukaryotic Orc1 and Cdc6. Archaeal replication origins have been mapped and their interactions with Orc1/Cdc6 proteins have been characterized at the biochemical level. ...
The initiation of DNA replication in most archaeal genomes is mediated by proteins related to eukaryotic Orc1 and Cdc6. Archaeal repl …
CDC6 as a Key Inhibitory Regulator of CDK1 Activation Dynamics and the Timing of Mitotic Entry and Progression.
El Dika M, Dudka D, Kloc M, Kubiak JZ. El Dika M, et al. Biology (Basel). 2023 Jun 14;12(6):855. doi: 10.3390/biology12060855. Biology (Basel). 2023. PMID: 37372141 Free PMC article. Review.
Herein, we review the molecular mechanisms that underlie the control of mitotic timing, with special emphasis on how CDC6/Xic1 function impacts CDK1 regulatory network in the Xenopus system. ...As a result, we propose a comprehensive model integrating CDC6/Xic1-depe …
Herein, we review the molecular mechanisms that underlie the control of mitotic timing, with special emphasis on how CDC6/Xic1 functi …
CDC6 is a possible biomarker for hepatocellular carcinoma.
Kong DG, Yao FZ. Kong DG, et al. Int J Clin Exp Pathol. 2021 Jul 15;14(7):811-818. eCollection 2021. Int J Clin Exp Pathol. 2021. PMID: 34367412 Free PMC article.
METHODS: We assessed the expression levels of CDC6 in a serious of cancers from GEPIA database. The expression of CDC6 in hepatocellular carcinoma tissue and normal liver tissue was compared, and further assessed by immunohistochemical staining. ...Detecting the exp …
METHODS: We assessed the expression levels of CDC6 in a serious of cancers from GEPIA database. The expression of CDC6 in hepa …
A GATA2-CDC6 axis modulates androgen receptor blockade-induced senescence in prostate cancer.
Mourkioti I, Polyzou A, Veroutis D, Theocharous G, Lagopati N, Gentile E, Stravokefalou V, Thanos DF, Havaki S, Kletsas D, Panaretakis T, Logothetis CJ, Stellas D, Petty R, Blandino G, Papaspyropoulos A, Gorgoulis VG. Mourkioti I, et al. J Exp Clin Cancer Res. 2023 Jul 29;42(1):187. doi: 10.1186/s13046-023-02769-z. J Exp Clin Cancer Res. 2023. PMID: 37507762 Free PMC article.
RESULTS: We demonstrate that enzalutamide treatment induces senescence in androgen-sensitive cells via reduction of the replication licensing factor CDC6. Mechanistically, we show that CDC6 downregulation is mediated through endogenous activation of the GATA2 transc …
RESULTS: We demonstrate that enzalutamide treatment induces senescence in androgen-sensitive cells via reduction of the replication licensin …
CDC6: from DNA replication to cell cycle checkpoints and oncogenesis.
Borlado LR, Méndez J. Borlado LR, et al. Carcinogenesis. 2008 Feb;29(2):237-43. doi: 10.1093/carcin/bgm268. Epub 2007 Nov 28. Carcinogenesis. 2008. PMID: 18048387 Review.
Cell division cycle 6 (CDC6) is an essential regulator of DNA replication in eukaryotic cells. ...These findings indicate that deregulation of CDC6 expression in human cells poses a serious risk of carcinogenesis....
Cell division cycle 6 (CDC6) is an essential regulator of DNA replication in eukaryotic cells. ...These findings indicate that deregu …
Cdc6 is sequentially regulated by PP2A-Cdc55, Cdc14, and Sic1 for origin licensing in S. cerevisiae.
Philip J, Örd M, Silva A, Singh S, Diffley JF, Remus D, Loog M, Ikui AE. Philip J, et al. Elife. 2022 Feb 10;11:e74437. doi: 10.7554/eLife.74437. Elife. 2022. PMID: 35142288 Free PMC article.
It has been extensively studied how Cdc6 phosphorylation is regulated by the cyclin-Cdk1 complex. However, a detailed mechanism on how Cdc6 phosphorylation is reversed by phosphatases has not been elucidated. Here, we show that PP2A(Cdc55) dephosphorylates Cdc6 …
It has been extensively studied how Cdc6 phosphorylation is regulated by the cyclin-Cdk1 complex. However, a detailed mechanism on ho …
Cdc6: a multi-functional molecular switch with critical role in carcinogenesis.
Petrakis TG, Vougas K, Gorgoulis VG. Petrakis TG, et al. Transcription. 2012 May-Jun;3(3):124-9. doi: 10.4161/trns.20301. Transcription. 2012. PMID: 22771947 Free PMC article. Review.
Research in the last decade revealed an additional role for the Replication Licensing Factor Cdc6 in transcriptional regulation. This novel function has been linked to human cancer development. Here, we summarize all the findings arguing over a role of Cdc6 as a tra …
Research in the last decade revealed an additional role for the Replication Licensing Factor Cdc6 in transcriptional regulation. This …
1,083 results