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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1978 1
1980 2
1981 1
1984 1
1986 2
1987 1
1988 5
1989 1
1990 1
1991 5
1992 1
1993 3
1994 1
1995 4
1996 1
1997 7
1998 6
1999 5
2000 3
2001 4
2002 6
2003 8
2004 6
2005 4
2006 6
2007 11
2008 5
2009 19
2010 16
2011 16
2012 16
2013 18
2014 29
2015 32
2016 31
2017 31
2018 32
2019 46
2020 39
2021 52
2022 47
2023 47
2024 22

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529 results

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Page 1
CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells.
Kim J, Hu Z, Cai L, Li K, Choi E, Faubert B, Bezwada D, Rodriguez-Canales J, Villalobos P, Lin YF, Ni M, Huffman KE, Girard L, Byers LA, Unsal-Kacmaz K, Peña CG, Heymach JV, Wauters E, Vansteenkiste J, Castrillon DH, Chen BPC, Wistuba I, Lambrechts D, Xu J, Minna JD, DeBerardinis RJ. Kim J, et al. Nature. 2017 Jun 1;546(7656):168-172. doi: 10.1038/nature22359. Epub 2017 May 24. Nature. 2017. PMID: 28538732 Free PMC article.
Transcription of CPS1 is suppressed by LKB1 through AMPK, and CPS1 expression correlates inversely with LKB1 in human NSCLC. Silencing CPS1 in KL cells induces cell death and reduces tumour growth. Notably, cell death results from pyrimidine depletion rather …
Transcription of CPS1 is suppressed by LKB1 through AMPK, and CPS1 expression correlates inversely with LKB1 in human NSCLC. S …
CPS1: Looking at an ancient enzyme in a modern light.
Nitzahn M, Lipshutz GS. Nitzahn M, et al. Mol Genet Metab. 2020 Nov;131(3):289-298. doi: 10.1016/j.ymgme.2020.10.003. Epub 2020 Oct 10. Mol Genet Metab. 2020. PMID: 33317798 Free PMC article. Review.
Symptoms in CPS1 deficiency are typically the most severe of all UC disorders, and current clinical management is insufficient to prevent the associated morbidities and high mortality. ...Here, we review recent advances in CPS1 biology and contextualize them around …
Symptoms in CPS1 deficiency are typically the most severe of all UC disorders, and current clinical management is insufficient to pre …
Unraveling the therapeutic potential of carbamoyl phosphate synthetase 1 (CPS1) in human diseases.
Zhang L, Zou Y, Lu Y, Li Z, Gao F. Zhang L, et al. Bioorg Chem. 2023 Jan;130:106253. doi: 10.1016/j.bioorg.2022.106253. Epub 2022 Nov 5. Bioorg Chem. 2023. PMID: 36356370 Review.
In particular, CPS1 expression varies among cancers, being overexpressed in some cancers and downregulated in others, suggesting that CPS1 may be a promising cancer therapeutic target. ...In this review, we describe the structure and function of CPS1, highlig …
In particular, CPS1 expression varies among cancers, being overexpressed in some cancers and downregulated in others, suggesting that …
CPS1 expression and its prognostic significance in lung adenocarcinoma.
Wu G, Zhao Z, Yan Y, Zhou Y, Wei J, Chen X, Lin W, Ou C, Li J, Wang X, Xiong K, Zhou J, Xu Z. Wu G, et al. Ann Transl Med. 2020 Mar;8(6):341. doi: 10.21037/atm.2020.02.146. Ann Transl Med. 2020. PMID: 32355785 Free PMC article.
Furthermore, we analyzed the methylation level of CPS1 in LADC and found that cases with high levels of CPS1 showed hypomethylated CPS1. ...CONCLUSIONS: Our work indicated that CPS1 is upregulated in LADC samples and that CPS1 might be used as a …
Furthermore, we analyzed the methylation level of CPS1 in LADC and found that cases with high levels of CPS1 showed hypomethyl …
O-GlcNAcylation enhances CPS1 catalytic efficiency for ammonia and promotes ureagenesis.
Soria LR, Makris G, D'Alessio AM, De Angelis A, Boffa I, Pravata VM, Rüfenacht V, Attanasio S, Nusco E, Arena P, Ferenbach AT, Paris D, Cuomo P, Motta A, Nitzahn M, Lipshutz GS, Martínez-Pizarro A, Richard E, Desviat LR, Häberle J, van Aalten DMF, Brunetti-Pierri N. Soria LR, et al. Nat Commun. 2022 Sep 5;13(1):5212. doi: 10.1038/s41467-022-32904-x. Nat Commun. 2022. PMID: 36064721 Free PMC article.
Mechanistically, O-GlcNAcylation on specific threonine residues increased the catalytic efficiency for ammonia of carbamoyl phosphate synthetase 1 (CPS1), the rate-limiting enzyme in ureagenesis. Pharmacological inhibition of O-GlcNAcase, the enzyme removing O-GlcNAc from …
Mechanistically, O-GlcNAcylation on specific threonine residues increased the catalytic efficiency for ammonia of carbamoyl phosphate synthe …
Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma.
Cancer Genome Atlas Research Network. Electronic address: wheeler@bcm.edu; Cancer Genome Atlas Research Network. Cancer Genome Atlas Research Network. Electronic address: wheeler@bcm.edu, et al. Cell. 2017 Jun 15;169(7):1327-1341.e23. doi: 10.1016/j.cell.2017.05.046. Cell. 2017. PMID: 28622513 Free PMC article.
Significant alterations by mutation or downregulation by hypermethylation in genes likely to result in HCC metabolic reprogramming (ALB, APOB, and CPS1) were observed. Integrative molecular HCC subtyping incorporating unsupervised clustering of five data platforms identifi …
Significant alterations by mutation or downregulation by hypermethylation in genes likely to result in HCC metabolic reprogramming (ALB, APO …
Urea Cycle Disorders Overview.
Ah Mew N, Simpson KL, Gropman AL, Lanpher BC, Chapman KA, Summar ML. Ah Mew N, et al. 2003 Apr 29 [updated 2017 Jun 22]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. 2003 Apr 29 [updated 2017 Jun 22]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. PMID: 20301396 Free Books & Documents. Review.
NAGS, CPS1, and SLC25A13 (Citrin) at the Crossroads of Arginine and Pyrimidines Metabolism in Tumor Cells.
Owusu-Ansah M, Guptan N, Alindogan D, Morizono M, Caldovic L. Owusu-Ansah M, et al. Int J Mol Sci. 2023 Apr 4;24(7):6754. doi: 10.3390/ijms24076754. Int J Mol Sci. 2023. PMID: 37047726 Free PMC article.
N-acetylglutamate (NAG), produced by NAG synthase (NAGS), is an essential activator of CPS1. Although NAGS is expressed in lung cancer derived cell lines, expression of the NAGS gene and its product was not evaluated in tumors with aberrant expression of CPS1 and ci …
N-acetylglutamate (NAG), produced by NAG synthase (NAGS), is an essential activator of CPS1. Although NAGS is expressed in lung cance …
LncRNA CPS1-IT1 serves as anti-oncogenic role in glioma.
Chen H, Li Q, Liang J, Jin M, Lu A. Chen H, et al. Biomed Pharmacother. 2019 Oct;118:109277. doi: 10.1016/j.biopha.2019.109277. Epub 2019 Aug 21. Biomed Pharmacother. 2019. PMID: 31545272 Free article.
Survival analysis showed glioma patients in low CPS1-IT1 expression group had shorter overall survival than those in high CPS1-IT1 expression group, and low CPS1-IT1 expression was an independent prognostic factor for overall survival in glioma patients. ...I …
Survival analysis showed glioma patients in low CPS1-IT1 expression group had shorter overall survival than those in high CPS1 …
SIRT5 regulation of ammonia-induced autophagy and mitophagy.
Polletta L, Vernucci E, Carnevale I, Arcangeli T, Rotili D, Palmerio S, Steegborn C, Nowak T, Schutkowski M, Pellegrini L, Sansone L, Villanova L, Runci A, Pucci B, Morgante E, Fini M, Mai A, Russo MA, Tafani M. Polletta L, et al. Autophagy. 2015;11(2):253-70. doi: 10.1080/15548627.2015.1009778. Autophagy. 2015. PMID: 25700560 Free PMC article.
In liver the mitochondrial sirtuin, SIRT5, controls ammonia detoxification by regulating CPS1, the first enzyme of the urea cycle. However, while SIRT5 is ubiquitously expressed, urea cycle and CPS1 are only present in the liver and, to a minor extent, in the kidney …
In liver the mitochondrial sirtuin, SIRT5, controls ammonia detoxification by regulating CPS1, the first enzyme of the urea cycle. Ho …
529 results