Dakin LA - Search Results

1

Synthesis of the C1'-C11' oxazole-containing side chain of leucascandrolide A. Application of a Sonogashira cross-coupling.

Dakin LA, Langille NF, Panek JS. Dakin LA, et al. J Org Chem. 2002 Sep 20;67(19):6812-5. doi: 10.1021/jo0204000. J Org Chem. 2002. PMID: 12227815

2

Sonogashira coupling of functionalized trifloyl oxazoles and thiazoles with terminal alkynes: synthesis of disubstituted heterocycles.

Langille NF, Dakin LA, Panek JS. Langille NF, et al. Among authors: dakin la. Org Lett. 2002 Jul 25;4(15):2485-8. doi: 10.1021/ol026099r. Org Lett. 2002. PMID: 12123357

3

A mild, chemoselective protocol for the removal of thioketals and thioacetals mediated by Dess-Martin periodinane.

Langille NF, Dakin LA, Panek JS. Langille NF, et al. Among authors: dakin la. Org Lett. 2003 Feb 20;5(4):575-8. doi: 10.1021/ol027518n. Org Lett. 2003. PMID: 12583773

4

Enantioselective [4 + 2]-annulation of chiral crotylsilanes: application to the synthesis of a C1-C22 fragment of leucascandrolide A.

Dakin LA, Panek JS. Dakin LA, et al. Org Lett. 2003 Oct 16;5(21):3995-8. doi: 10.1021/ol035581m. Org Lett. 2003. PMID: 14535762

5

[4 + 2]-annulations of chiral organosilanes: Application to the total synthesis of leucascandrolide A.

Su Q, Dakin LA, Panek JS. Su Q, et al. Among authors: dakin la. J Org Chem. 2007 Jan 5;72(1):2-24. doi: 10.1021/jo0610412. J Org Chem. 2007. PMID: 17194076

6

A practical synthesis of indoles via a Pd-catalyzed C-N ring formation.

Vaswani RG, Albrecht BK, Audia JE, Côté A, Dakin LA, Duplessis M, Gehling VS, Harmange JC, Hewitt MC, Leblanc Y, Nasveschuk CG, Taylor AM. Vaswani RG, et al. Among authors: dakin la. Org Lett. 2014 Aug 15;16(16):4114-7. doi: 10.1021/ol5018118. Epub 2014 Jul 28. Org Lett. 2014. PMID: 25068576

7

Slow-onset, long-duration, alkyl analogues of methylphenidate with enhanced selectivity for the dopamine transporter.

Froimowitz M, Gu Y, Dakin LA, Nagafuji PM, Kelley CJ, Parrish D, Deschamps JR, Janowsky A. Froimowitz M, et al. Among authors: dakin la. J Med Chem. 2007 Jan 25;50(2):219-32. doi: 10.1021/jm0608614. J Med Chem. 2007. PMID: 17228864

8

Discovery of novel hedgehog antagonists from cell-based screening: Isosteric modification of p38 bisamides as potent inhibitors of SMO.

Yang B, Hird AW, Russell DJ, Fauber BP, Dakin LA, Zheng X, Su Q, Godin R, Brassil P, Devereaux E, Janetka JW. Yang B, et al. Among authors: dakin la. Bioorg Med Chem Lett. 2012 Jul 15;22(14):4907-11. doi: 10.1016/j.bmcl.2012.04.104. Epub 2012 Apr 30. Bioorg Med Chem Lett. 2012. PMID: 22704236

9

Heteroarylamide smoothened inhibitors: Discovery of N-[2,4-dimethyl-5-(1-methylimidazol-4-yl)phenyl]-4-(2-pyridylmethoxy)benzamide (AZD8542) and N-[5-(1H-imidazol-2-yl)-2,4-dimethyl-phenyl]-4-(2- pyridylmethoxy)benzamide (AZD7254).

Yang B, Hird AW, Bodnarchuk MS, Zheng X, Dakin L, Su Q, Daly K, Godin R, Hattersley MM, Brassil P, Redmond S, John Russell D, Janetka JW. Yang B, et al. Bioorg Med Chem. 2020 Jan 15;28(2):115227. doi: 10.1016/j.bmc.2019.115227. Epub 2019 Dec 11. Bioorg Med Chem. 2020. PMID: 31862310

10

Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637).

Taylor AM, Côté A, Hewitt MC, Pastor R, Leblanc Y, Nasveschuk CG, Romero FA, Crawford TD, Cantone N, Jayaram H, Setser J, Murray J, Beresini MH, de Leon Boenig G, Chen Z, Conery AR, Cummings RT, Dakin LA, Flynn EM, Huang OW, Kaufman S, Keller PJ, Kiefer JR, Lai T, Li Y, Liao J, Liu W, Lu H, Pardo E, Tsui V, Wang J, Wang Y, Xu Z, Yan F, Yu D, Zawadzke L, Zhu X, Zhu X, Sims RJ 3rd, Cochran AG, Bellon S, Audia JE, Magnuson S, Albrecht BK. Taylor AM, et al. Among authors: dakin la. ACS Med Chem Lett. 2016 Mar 15;7(5):531-6. doi: 10.1021/acsmedchemlett.6b00075. eCollection 2016 May 12. ACS Med Chem Lett. 2016. PMID: 27190605 Free PMC article.

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