Devine PN - Search Results

1

Asymmetric synthesis of cis-2,5-disubstituted pyrrolidine, the core scaffold of β3-AR agonists.

Xu F, Chung JY, Moore JC, Liu Z, Yoshikawa N, Hoerrner RS, Lee J, Royzen M, Cleator E, Gibson AG, Dunn R, Maloney KM, Alam M, Goodyear A, Lynch J, Yasuda N, Devine PN. Xu F, et al. Among authors: devine pn. Org Lett. 2013 Mar 15;15(6):1342-5. doi: 10.1021/ol400252p. Epub 2013 Mar 1. Org Lett. 2013. PMID: 23451898

2

Asymmetric synthesis of telcagepant, a CGRP receptor antagonist for the treatment of migraine.

Xu F, Zacuto M, Yoshikawa N, Desmond R, Hoerrner S, Itoh T, Journet M, Humphrey GR, Cowden C, Strotman N, Devine P. Xu F, et al. J Org Chem. 2010 Nov 19;75(22):7829-41. doi: 10.1021/jo101704b. Epub 2010 Oct 18. J Org Chem. 2010. PMID: 20954694

3

Synthesis of Grazoprevir, a Potent NS3/4a Protease Inhibitor for the Treatment of Hepatitis C Virus.

Xu F, Kim J, Waldman J, Wang T, Devine P. Xu F, et al. Org Lett. 2018 Nov 16;20(22):7261-7265. doi: 10.1021/acs.orglett.8b03173. Epub 2018 Nov 2. Org Lett. 2018. PMID: 30388018

4

Copper-catalyzed synthesis of enantioenriched tetraarylethanes.

Jen WS, Truppo MD, Amos D, Devine P, McNevin M, Biba M, Campos KR. Jen WS, et al. Org Lett. 2008 Mar 6;10(5):741-4. doi: 10.1021/ol7027543. Epub 2008 Feb 2. Org Lett. 2008. PMID: 18247494

5

Enzyme-catalyzed enantioselective diaryl ketone reductions.

Truppo MD, Pollard D, Devine P. Truppo MD, et al. Org Lett. 2007 Jan 18;9(2):335-8. doi: 10.1021/ol0627909. Org Lett. 2007. PMID: 17217298

6

Chemo- and enantioselective routes to chiral fluorinated hydroxyketones using ketoreductases.

Grau BT, Devine PN, DiMichele LN, Kosjek B. Grau BT, et al. Among authors: devine pn. Org Lett. 2007 Nov 22;9(24):4951-4. doi: 10.1021/ol701810v. Epub 2007 Oct 31. Org Lett. 2007. PMID: 17973397

7

Design of an in vitro biocatalytic cascade for the manufacture of islatravir.

Huffman MA, Fryszkowska A, Alvizo O, Borra-Garske M, Campos KR, Canada KA, Devine PN, Duan D, Forstater JH, Grosser ST, Halsey HM, Hughes GJ, Jo J, Joyce LA, Kolev JN, Liang J, Maloney KM, Mann BF, Marshall NM, McLaughlin M, Moore JC, Murphy GS, Nawrat CC, Nazor J, Novick S, Patel NR, Rodriguez-Granillo A, Robaire SA, Sherer EC, Truppo MD, Whittaker AM, Verma D, Xiao L, Xu Y, Yang H. Huffman MA, et al. Among authors: devine pn. Science. 2019 Dec 6;366(6470):1255-1259. doi: 10.1126/science.aay8484. Science. 2019. PMID: 31806816

8

Synthesis of vaniprevir (MK-7009): lactamization to prepare a 20-membered [corrected] macrocycle.

Song ZJ, Tellers DM, Journet M, Kuethe JT, Lieberman D, Humphrey G, Zhang F, Peng Z, Waters MS, Zewge D, Nolting A, Zhao D, Reamer RA, Dormer PG, Belyk KM, Davies IW, Devine PN, Tschaen DM. Song ZJ, et al. Among authors: devine pn. J Org Chem. 2011 Oct 7;76(19):7804-15. doi: 10.1021/jo2011494. Epub 2011 Aug 31. J Org Chem. 2011. PMID: 21838271

9

An efficient chemoenzymatic approach to (S)-gamma-fluoroleucine ethyl ester.

Limanto J, Shafiee A, Devine PN, Upadhyay V, Desmond RA, Foster BR, Gauthier DR Jr, Reamer RA, Volante RP. Limanto J, et al. Among authors: devine pn. J Org Chem. 2005 Mar 18;70(6):2372-5. doi: 10.1021/jo047918j. J Org Chem. 2005. PMID: 15760235

10

Palladium-catalyzed regioselective arylation of imidazo[1,2-b][1,2,4]triazine: synthesis of an alpha 2/3-selective GABA agonist.

Gauthier DR Jr, Limanto J, Devine PN, Desmond RA, Szumigala RH Jr, Foster BS, Volante RP. Gauthier DR Jr, et al. Among authors: devine pn. J Org Chem. 2005 Jul 22;70(15):5938-45. doi: 10.1021/jo0507035. J Org Chem. 2005. PMID: 16018689

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