Doench J - Search Results

1

Bromodomain Inhibitors Correct Bioenergetic Deficiency Caused by Mitochondrial Disease Complex I Mutations.

Barrow JJ, Balsa E, Verdeguer F, Tavares CD, Soustek MS, Hollingsworth LR 4th, Jedrychowski M, Vogel R, Paulo JA, Smeitink J, Gygi SP, Doench J, Root DE, Puigserver P. Barrow JJ, et al. Among authors: doench j. Mol Cell. 2016 Oct 6;64(1):163-175. doi: 10.1016/j.molcel.2016.08.023. Epub 2016 Sep 22. Mol Cell. 2016. PMID: 27666594 Free PMC article.

2

Recapitulation of short RNA-directed translational gene silencing in vitro.

Wang B, Love TM, Call ME, Doench JG, Novina CD. Wang B, et al. Mol Cell. 2006 May 19;22(4):553-60. doi: 10.1016/j.molcel.2006.03.034. Mol Cell. 2006. PMID: 16713585 Free article.

3

Reduced expression of ribosomal proteins relieves microRNA-mediated repression.

Janas MM, Wang E, Love T, Harris AS, Stevenson K, Semmelmann K, Shaffer JM, Chen PH, Doench JG, Yerramilli SV, Neuberg DS, Iliopoulos D, Housman DE, Burge CB, Novina CD. Janas MM, et al. Mol Cell. 2012 Apr 27;46(2):171-86. doi: 10.1016/j.molcel.2012.04.008. Mol Cell. 2012. PMID: 22541556 Free article.

4

Discovery and characterization of super-enhancer-associated dependencies in diffuse large B cell lymphoma.

Chapuy B, McKeown MR, Lin CY, Monti S, Roemer MG, Qi J, Rahl PB, Sun HH, Yeda KT, Doench JG, Reichert E, Kung AL, Rodig SJ, Young RA, Shipp MA, Bradner JE. Chapuy B, et al. Among authors: doench jg. Cancer Cell. 2013 Dec 9;24(6):777-90. doi: 10.1016/j.ccr.2013.11.003. Cancer Cell. 2013. PMID: 24332044 Free PMC article.

5

Genome-scale CRISPR-Cas9 knockout screening in human cells.

Shalem O, Sanjana NE, Hartenian E, Shi X, Scott DA, Mikkelson T, Heckl D, Ebert BL, Root DE, Doench JG, Zhang F. Shalem O, et al. Science. 2014 Jan 3;343(6166):84-87. doi: 10.1126/science.1247005. Epub 2013 Dec 12. Science. 2014. PMID: 24336571 Free PMC article.

6

Targeted shRNA screening identified critical roles of pleckstrin-2 in erythropoiesis.

Zhao B, Keerthivasan G, Mei Y, Yang J, McElherne J, Wong P, Doench JG, Feng G, Root DE, Ji P. Zhao B, et al. Among authors: doench jg. Haematologica. 2014 Jul;99(7):1157-67. doi: 10.3324/haematol.2014.105809. Epub 2014 Apr 18. Haematologica. 2014. PMID: 24747950 Free PMC article.

7

Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation.

Doench JG, Hartenian E, Graham DB, Tothova Z, Hegde M, Smith I, Sullender M, Ebert BL, Xavier RJ, Root DE. Doench JG, et al. Nat Biotechnol. 2014 Dec;32(12):1262-7. doi: 10.1038/nbt.3026. Epub 2014 Sep 3. Nat Biotechnol. 2014. PMID: 25184501 Free PMC article.

8

HDAC5 controls MEF2C-driven sclerostin expression in osteocytes.

Wein MN, Spatz J, Nishimori S, Doench J, Root D, Babij P, Nagano K, Baron R, Brooks D, Bouxsein M, Pajevic PD, Kronenberg HM. Wein MN, et al. Among authors: doench j. J Bone Miner Res. 2015 Mar;30(3):400-11. doi: 10.1002/jbmr.2381. J Bone Miner Res. 2015. PMID: 25271055 Free PMC article.

9

DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia.

Chen CW, Koche RP, Sinha AU, Deshpande AJ, Zhu N, Eng R, Doench JG, Xu H, Chu SH, Qi J, Wang X, Delaney C, Bernt KM, Root DE, Hahn WC, Bradner JE, Armstrong SA. Chen CW, et al. Among authors: doench jg. Nat Med. 2015 Apr;21(4):335-43. doi: 10.1038/nm.3832. Epub 2015 Mar 30. Nat Med. 2015. PMID: 25822366 Free PMC article.

10

Malaria. A forward genetic screen identifies erythrocyte CD55 as essential for Plasmodium falciparum invasion.

Egan ES, Jiang RH, Moechtar MA, Barteneva NS, Weekes MP, Nobre LV, Gygi SP, Paulo JA, Frantzreb C, Tani Y, Takahashi J, Watanabe S, Goldberg J, Paul AS, Brugnara C, Root DE, Wiegand RC, Doench JG, Duraisingh MT. Egan ES, et al. Among authors: doench jg. Science. 2015 May 8;348(6235):711-4. doi: 10.1126/science.aaa3526. Science. 2015. PMID: 25954012 Free PMC article.

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