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Thiopurines inhibit coronavirus Spike protein processing and incorporation into progeny virions.
Pringle ES, Duguay BA, Bui-Marinos MP, Mulloy RP, Landreth SL, Desireddy KS, Dolliver SM, Ying S, Caddell T, Tooley TH, Slaine PD, Bearne SL, Falzarano D, Corcoran JA, Khaperskyy DA, McCormick C. Pringle ES, et al. Among authors: falzarano d. PLoS Pathog. 2022 Sep 19;18(9):e1010832. doi: 10.1371/journal.ppat.1010832. eCollection 2022 Sep. PLoS Pathog. 2022. PMID: 36121863 Free PMC article.
Previous infection with seasonal coronaviruses does not protect male Syrian hamsters from challenge with SARS-CoV-2.
Francis ME, Jansen EB, Yourkowski A, Selim A, Swan CL, MacPhee BK, Thivierge B, Buchanan R, Lavender KJ, Darbellay J, Rogers MB, Lew J, Gerdts V, Falzarano D, Skowronski DM, Sjaarda C, Kelvin AA. Francis ME, et al. Among authors: falzarano d. Nat Commun. 2023 Sep 26;14(1):5990. doi: 10.1038/s41467-023-41761-1. Nat Commun. 2023. PMID: 37752151 Free PMC article.
High Potency of a Bivalent Human VH Domain in SARS-CoV-2 Animal Models.
Li W, Schäfer A, Kulkarni SS, Liu X, Martinez DR, Chen C, Sun Z, Leist SR, Drelich A, Zhang L, Ura ML, Berezuk A, Chittori S, Leopold K, Mannar D, Srivastava SS, Zhu X, Peterson EC, Tseng CT, Mellors JW, Falzarano D, Subramaniam S, Baric RS, Dimitrov DS. Li W, et al. Among authors: falzarano d. Cell. 2020 Oct 15;183(2):429-441.e16. doi: 10.1016/j.cell.2020.09.007. Epub 2020 Sep 4. Cell. 2020. PMID: 32941803 Free PMC article.
Rapid identification of a human antibody with high prophylactic and therapeutic efficacy in three animal models of SARS-CoV-2 infection.
Li W, Chen C, Drelich A, Martinez DR, Gralinski LE, Sun Z, Schäfer A, Kulkarni SS, Liu X, Leist SR, Zhelev DV, Zhang L, Kim YJ, Peterson EC, Conard A, Mellors JW, Tseng CK, Falzarano D, Baric RS, Dimitrov DS. Li W, et al. Among authors: falzarano d. Proc Natl Acad Sci U S A. 2020 Nov 24;117(47):29832-29838. doi: 10.1073/pnas.2010197117. Epub 2020 Nov 2. Proc Natl Acad Sci U S A. 2020. PMID: 33139569 Free PMC article.
SARS-CoV-2 infection in the Syrian hamster model causes inflammation as well as type I interferon dysregulation in both respiratory and non-respiratory tissues including the heart and kidney.
Francis ME, Goncin U, Kroeker A, Swan C, Ralph R, Lu Y, Etzioni AL, Falzarano D, Gerdts V, Machtaler S, Kindrachuk J, Kelvin AA. Francis ME, et al. Among authors: falzarano d. PLoS Pathog. 2021 Jul 15;17(7):e1009705. doi: 10.1371/journal.ppat.1009705. eCollection 2021 Jul. PLoS Pathog. 2021. PMID: 34265022 Free PMC article.
83 results